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33141por Ratuszny, Dominica, Skripuletz, Thomas, Stüber, Thomas, Valizada, Emil, Gehring, Klaus, Ertl, Philipp, Müller, Jörg Andreas, Wattjes, Mike P., Feuerhake, Friedrich, Sühs, Kurt-Wolfram“…METHODS: We present a young woman with prediagnosis of relapse remitting multiple sclerosis (MS), treated with interferons, natalizumab, and alemtuzumab. Six months after one and only cycle of alemtuzumab, speech arrest and behavioral changes with aggressive and anxious traits appeared. …”
Publicado 2023
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33142por Alharbi, Sadan, Alsubaie, Mohammed, Alzayyat, Remah, Alattas, Batool, AlAhmadi, Hassan, Alabdullatif, Hanoof“…Possible link is the suppression of type-one interferons caused by the mRNA-based vaccine such as COVID-19 vaccines. …”
Publicado 2023
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33143por Uccello, Taylor P., Lesch, Maggie L., Kintzel, Sarah A., Gradzewicz, Lauren B., Lamrous, Lillia, Murphy, Shawn P., Fleming, Fergal J., Mills, Bradley N., Murphy, Joseph D., Hughson, Angela, Hannon, Gary, Garrett-Larsen, Jesse, Qiu, Haoming, Drage, Michael G., Ye, Jian, Gavras, Nicholas W., Keeley, David C., Love, Tanzy M. T., Repasky, Elizabeth A., Lord, Edith M., Linehan, David C., Gerber, Scott A.“…This signature was dependent on radiation-induced increases of Type I Interferons (IFNs). We investigated a therapeutic approach targeting the cGAS/STING pathway and demonstrated improved response rate following radiotherapy. …”
Publicado 2023
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33144por Bentler, Martin, Hardet, Romain, Ertelt, Moritz, Rudolf, Daniela, Kaniowska, Dorota, Schneider, Andreas, Vondran, Florian W.R., Schoeder, Clara T., Delphin, Marion, Lucifora, Julie, Ott, Michael, Hacker, Ulrich T., Adriouch, Sahil, Büning, Hildegard“…In line with our hypothesis, AAV2.MB453 and AAV2 differed regarding innate immune response activation in primary human cells, particularly for type I interferons. Furthermore, mice treated with AAV2.MB453 showed significantly reduced CD8(+) T cell responses against the transgene product for different administration routes and against the capsid following intramuscular administration. …”
Publicado 2023
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33145por Mehrani, Yeganeh, Knapp, Jason P., Kakish, Julia E., Tieu, Sophie, Javadi, Helia, Chan, Lily, Stegelmeier, Ashley A., Napoleoni, Christina, Bridle, Byram W., Karimi, Khalil“…MCs produce, and have receptors for interferons (IFNs), which belong to a family of cytokines recognized for their antiviral properties. …”
Publicado 2023
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33146por Díaz-Alvarez, Laura, Martínez-Sánchez, Mariana Esther, Gray, Eleanor, Pérez-Figueroa, Erandi, Ortega, Enrique“…Additionally, after only 10 min at 37 °C, cells with crosslinked CD13 start secreting pro-inflammatory cytokines like interferons type 1 and 2, IL-12p70, and IL-17a. We integrated our data with a bioinformatic analysis to confirm the connection between these receptors and to suggest the signaling cascade linking them. …”
Publicado 2023
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33147“…Supernatants were tested for cytokines, interferons, chemokines, and growth factors using Luminex arrays. …”
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33148por Lee, Chang-Won, Bakre, Abhijeet, Olivier, Timothy L., Alvarez-Narvaez, Sonsiray, Harrell, Telvin L., Conrad, Steven J.“…The activation of TLRs leads to antiviral responses, including the induction of type I interferons (IFNs). In this study, birds were vaccinated intranasally with a live LaSota strain with or without imiquimod or ODN-1826 (50 µg/bird). …”
Publicado 2023
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33149por Narayanan, Divya, Moily, Nagaraj, McQuilten, Hayley A., Kedzierska, Katherine, Mackenzie, Jason M., Kedzierski, Lukasz, Fazakerley, John K.“…As in other tissues, innate antiviral responses mediated by type I interferons (IFNs) are crucially important in controlling CNS virus infections. …”
Publicado 2022
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33150“…BACKGROUND: Interferons play a critical role in regulating both the innate and adaptive immune responses. …”
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33151por Zhang, Xiaohong, Fujii, Hideki, Kishimoto, Hidehiro, LeRoy, Eric, Surh, Charles D., Sprent, Jonathan“…Second, the impaired in vivo response of aged CD44(hi) CD8(+) cells to IL-15 correlated with increased serum levels of type I interferons (IFN-I) and was largely reversed by injection of anti–IFN-I antibody. …”
Publicado 2002
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33152“…Ad5 IC induced more notable DC maturation, as indicated by increased CD86 expression, decreased endocytosis, and production of tumor necrosis factor and type I interferons. We found that DC stimulation by Ad5 IC was mediated by the Fcγ receptor IIa and Toll-like receptor 9 interactions. …”
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33153“…Factors underlying the ‘exacerbation‐prone’ phenotype are incompletely understood but include extrinsic factors: cigarette smoking, medication non‐compliance, psychosocial factors, and co‐morbidities such as gastroesophageal reflux disease, rhinosinusitis, obesity, and intolerance to non‐steroidal anti‐inflammatory medications; as well as intrinsic factors such as deficient epithelial cell production of the anti‐viral type I interferons (IFN‐α and IFN‐β). A better understanding of the biologic mechanisms of host susceptibility to recurrent exacerbations will be important for developing more effective preventions and treatments aimed at reducing the significant cost and morbidity associated with this important global health problem.…”
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33154“…BACKGROUND: Type I and type II interferons (IFNs) exert their effects mainly through the JAK/STAT pathway, which is presently best described in mammals. …”
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33155por González-Reyes, Salomé, Marín, Laura, González, Lucía, González, Luis O, del Casar, José M, Lamelas, Maria L, González-Quintana, José M, Vizoso, Francisco J“…By activating the production of several biological factors, TLRs induce type I interferons and other cytokines, which drive an inflammatory response and activate the adaptive immune system. …”
Publicado 2010
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33156por Coler, Rhea N., Bertholet, Sylvie, Moutaftsi, Magdalini, Guderian, Jeff A., Windish, Hillarie Plessner, Baldwin, Susan L., Laughlin, Elsa M., Duthie, Malcolm S., Fox, Christopher B., Carter, Darrick, Friede, Martin, Vedvick, Thomas S., Reed, Steven G.“…Innate immune responses to vaccine adjuvants based on lipopolysaccharide (LPS), a component of Gram-negative bacterial cell walls, are driven by Toll-like receptor (TLR) 4 and adaptor proteins including MyD88 and TRIF, leading to the production of inflammatory cytokines, type I interferons, and chemokines. We report here on the characterization of a synthetic hexaacylated lipid A derivative, denoted as glucopyranosyl lipid adjuvant (GLA). …”
Publicado 2011
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33157por Rebel, Johanna MJ, Peeters, Ben, Fijten, Helmi, Post, Jacob, Cornelissen, Jan, Vervelde, Lonneke“…No major difference between LPAI and HPAI infected birds in the induction of cytokines and interferons at mRNA level in lung tissue was found. …”
Publicado 2011
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33158por de Almeida, Leonardo A., Carvalho, Natalia B., Oliveira, Fernanda S., Lacerda, Thais L. S., Vasconcelos, Anilton C., Nogueira, Lucas, Bafica, Andre, Silva, Aristóbolo M., Oliveira, Sergio C.“…Type I interferons (IFNs) are cytokines that orchestrate diverse immune responses to viral and bacterial infections. …”
Publicado 2011
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33159por Sridharan, Aishwarya, Esposo, Marc, Kaushal, Khushboo, Tay, Jia, Osann, Kathyrn, Agrawal, Sudhanshu, Gupta, Sudhir, Agrawal, Anshu“…In the present study, we have investigated the effect of advancing age on plasmacytoid dendritic cell (PDC) function because they are critical in generating a robust antiviral response via the secretion of interferons (IFN). Our results indicate that PDCs from the aged are impaired in their capacity to secrete IFN-I in response to influenza virus and CPG stimulation. …”
Publicado 2010
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33160por Emamian, Eshrat S., Leon, Joanlise M., Lessard, Christopher J., Grandits, Martha, Baechler, Emily C., Gaffney, Patrick M., Segal, Barbara, Rhodus, Nelson L., Moser, Kathy L.“…We first analyzed 21 SS cases and 23 controls and identified a prominent pattern of overexpressed genes that are inducible by interferons (IFNs). These results were confirmed by evaluation of a second independent dataset of 17 SS cases and 22 controls. …”
Publicado 2009
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