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  1. 33141
    “…METHODS: We present a young woman with prediagnosis of relapse remitting multiple sclerosis (MS), treated with interferons, natalizumab, and alemtuzumab. Six months after one and only cycle of alemtuzumab, speech arrest and behavioral changes with aggressive and anxious traits appeared. …”
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    Anti–GABA-A Receptor Antibody-Mediated Epilepsia Partialis Continua After Treatment With Alemtuzumab: A Case Report
  2. 33142
    “…Possible link is the suppression of type-one interferons caused by the mRNA-based vaccine such as COVID-19 vaccines. …”
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    Herpes Zoster Virus Reactivation in a 16 Year Old Female Post COVID-19 Vaccine. Case report and Review of the Literature
  3. 33143
    “…This signature was dependent on radiation-induced increases of Type I Interferons (IFNs). We investigated a therapeutic approach targeting the cGAS/STING pathway and demonstrated improved response rate following radiotherapy. …”
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    New insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy
  4. 33144
    “…In line with our hypothesis, AAV2.MB453 and AAV2 differed regarding innate immune response activation in primary human cells, particularly for type I interferons. Furthermore, mice treated with AAV2.MB453 showed significantly reduced CD8(+) T cell responses against the transgene product for different administration routes and against the capsid following intramuscular administration. …”
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    Modifying immune responses to adeno-associated virus vectors by capsid engineering
  5. 33145
    “…MCs produce, and have receptors for interferons (IFNs), which belong to a family of cytokines recognized for their antiviral properties. …”
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    Murine Mast Cells That Are Deficient in IFNAR-Signaling Respond to Viral Infection by Producing a Large Amount of Inflammatory Cytokines, a Low Level of Reactive Oxygen Species, and a High Rate of Cell Death
  6. 33146
    “…Additionally, after only 10 min at 37 °C, cells with crosslinked CD13 start secreting pro-inflammatory cytokines like interferons type 1 and 2, IL-12p70, and IL-17a. We integrated our data with a bioinformatic analysis to confirm the connection between these receptors and to suggest the signaling cascade linking them. …”
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    Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18 †
  7. 33147
    “…Supernatants were tested for cytokines, interferons, chemokines, and growth factors using Luminex arrays. …”
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    Differential Immune-Modulating Activities of Cell Walls and Secreted Metabolites from Probiotic Bacillus coagulans JBI-YZ6.3 under Normal versus Inflamed Culture Conditions
  8. 33148
    “…The activation of TLRs leads to antiviral responses, including the induction of type I interferons (IFNs). In this study, birds were vaccinated intranasally with a live LaSota strain with or without imiquimod or ODN-1826 (50 µg/bird). …”
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    Toll-like Receptor Ligands Enhance Vaccine Efficacy against a Virulent Newcastle Disease Virus Challenge in Chickens
  9. 33149
    “…As in other tissues, innate antiviral responses mediated by type I interferons (IFNs) are crucially important in controlling CNS virus infections. …”
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    Immature Brain Cortical Neurons Have Low Transcriptional Competence to Activate Antiviral Defences and Control RNA Virus Infections
  10. 33150
    “…BACKGROUND: Interferons play a critical role in regulating both the innate and adaptive immune responses. …”
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    The role of IFN-γ in regulation of IFN-γ-inducible protein 10 (IP-10) expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures
  11. 33151
    “…Second, the impaired in vivo response of aged CD44(hi) CD8(+) cells to IL-15 correlated with increased serum levels of type I interferons (IFN-I) and was largely reversed by injection of anti–IFN-I antibody. …”
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    Aging Leads to Disturbed Homeostasis of Memory Phenotype CD8(+) Cells
  12. 33152
    “…Ad5 IC induced more notable DC maturation, as indicated by increased CD86 expression, decreased endocytosis, and production of tumor necrosis factor and type I interferons. We found that DC stimulation by Ad5 IC was mediated by the Fcγ receptor IIa and Toll-like receptor 9 interactions. …”
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    Activation of a dendritic cell–T cell axis by Ad5 immune complexes creates an improved environment for replication of HIV in T cells
  13. 33153
    por Dougherty, R. H., Fahy, J. V.
    Publicado 2009
    “…Factors underlying the ‘exacerbation‐prone’ phenotype are incompletely understood but include extrinsic factors: cigarette smoking, medication non‐compliance, psychosocial factors, and co‐morbidities such as gastroesophageal reflux disease, rhinosinusitis, obesity, and intolerance to non‐steroidal anti‐inflammatory medications; as well as intrinsic factors such as deficient epithelial cell production of the anti‐viral type I interferons (IFN‐α and IFN‐β). A better understanding of the biologic mechanisms of host susceptibility to recurrent exacerbations will be important for developing more effective preventions and treatments aimed at reducing the significant cost and morbidity associated with this important global health problem.…”
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    Acute exacerbations of asthma: epidemiology, biology and the exacerbation‐prone phenotype
  14. 33154
    “…BACKGROUND: Type I and type II interferons (IFNs) exert their effects mainly through the JAK/STAT pathway, which is presently best described in mammals. …”
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    Structural and functional studies of STAT1 from Atlantic salmon (Salmo salar)
  15. 33155
    “…By activating the production of several biological factors, TLRs induce type I interferons and other cytokines, which drive an inflammatory response and activate the adaptive immune system. …”
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    Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis
  16. 33156
    “…Innate immune responses to vaccine adjuvants based on lipopolysaccharide (LPS), a component of Gram-negative bacterial cell walls, are driven by Toll-like receptor (TLR) 4 and adaptor proteins including MyD88 and TRIF, leading to the production of inflammatory cytokines, type I interferons, and chemokines. We report here on the characterization of a synthetic hexaacylated lipid A derivative, denoted as glucopyranosyl lipid adjuvant (GLA). …”
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    Development and Characterization of Synthetic Glucopyranosyl Lipid Adjuvant System as a Vaccine Adjuvant
  17. 33157
    “…No major difference between LPAI and HPAI infected birds in the induction of cytokines and interferons at mRNA level in lung tissue was found. …”
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    Highly pathogenic or low pathogenic avian influenza virus subtype H7N1 infection in chicken lungs: small differences in general acute responses
  18. 33158
    “…Type I interferons (IFNs) are cytokines that orchestrate diverse immune responses to viral and bacterial infections. …”
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    MyD88 and STING Signaling Pathways Are Required for IRF3-Mediated IFN-β Induction in Response to Brucella abortus Infection
  19. 33159
    “…In the present study, we have investigated the effect of advancing age on plasmacytoid dendritic cell (PDC) function because they are critical in generating a robust antiviral response via the secretion of interferons (IFN). Our results indicate that PDCs from the aged are impaired in their capacity to secrete IFN-I in response to influenza virus and CPG stimulation. …”
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    Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity
  20. 33160
    “…We first analyzed 21 SS cases and 23 controls and identified a prominent pattern of overexpressed genes that are inducible by interferons (IFNs). These results were confirmed by evaluation of a second independent dataset of 17 SS cases and 22 controls. …”
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    Peripheral blood gene expression profiling in Sjögren’s syndrome
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