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33161por Huizinga, Ruth, Easton, Alistair S., Donachie, Anne M., Guthrie, Jim, van Rijs, Wouter, Heikema, Astrid, Boon, Louis, Samsom, Janneke N., Jacobs, Bart C., Willison, Hugh J., Goodyear, Carl S.“…In addition, sialylation significantly amplified the production of type I interferons, which was independent of pDC. CONCLUSIONS/SIGNIFICANCE: These results identify novel immune stimulatory effects of C. jejuni sialylation, which may be important in inducing cross-reactive humoral responses that cause GBS.…”
Publicado 2012
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33162por Parato, Kelley A, Breitbach, Caroline J, Le Boeuf, Fabrice, Wang, Jiahu, Storbeck, Chris, Ilkow, Carolina, Diallo, Jean-Simon, Falls, Theresa, Burns, Joseph, Garcia, Vanessa, Kanji, Femina, Evgin, Laura, Hu, Kang, Paradis, Francois, Knowles, Shane, Hwang, Tae-Ho, Vanderhyden, Barbara C, Auer, Rebecca, Kirn, David H, Bell, John C“…JX-594 cancer-selectivity was multi-mechanistic; replication was activated by epidermal growth factor receptor (EGFR)/Ras pathway signaling, cellular TK levels, and cancer cell resistance to type-I interferons (IFNs). These findings confirm a large therapeutic index for JX-594 that is driven by common genetic abnormalities in human solid tumors. …”
Publicado 2012
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33163por Lo, Calvin C., Schwartz, Jordan A., Johnson, Dylan J., Yu, Monica, Aidarus, Nasra, Mujib, Shariq, Benko, Erika, Hyrcza, Martin, Kovacs, Colin, Ostrowski, Mario A.“…Plasmacytoid dendritic cells (pDC) are the major producers of type I interferons (IFNs) in humans and rapidly produce IFN-α in response to virus exposure. …”
Publicado 2012
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33164por Kren, Leos, Valkovsky, Ivo, Dolezel, Jan, Capak, Ivo, Pacik, Dalibor, Poprach, Alexandr, Lakomy, Radek, Redova, Martina, Fabian, Pavel, Krenova, Zdenka, Slaby, Ondrej“…CONCLUSION: Considering the fact that there is known aberrant activation of HLA-G and HLA-E expression by interferons, identification of HLA-G and HLA-E status could contribute to better selection of RCC patients who could possibly benefit from more tailored neoadjuvant biological/immunological therapy. …”
Publicado 2012
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33165“…These signaling pathways share several key downstream signaling adaptors and therefore produce similar downstream effects such as the production of pro-inflammatory cytokines, chemokines, and interferons. This review will examine in depth the specific interactions of miRNAs with receptors, adaptor molecules, and regulator molecules within these cellular pathways. …”
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33166por Hwang, Ilwoong, Scott, Jeannine M., Kakarla, Tejaswi, Duriancik, David M., Choi, Seohyun, Cho, Chunghwan, Lee, Taehyung, Park, Hyojin, French, Anthony R., Beli, Eleni, Gardner, Elizabeth, Kim, Sungjin“…Analysis of cytokine receptor deficient mice demonstrated that type I interferons (IFNs), but not IL-12 or IL-18, were critical for the NK cell expression of both IFN-γ and granzyme B in response to flu infection. …”
Publicado 2012
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33167por Blüml, Stephan, McKeever, Kathleen, Ettinger, Rachel, Smolen, Josef, Herbst, Ronald“…DNA-and RNA-containing immune complexes can also induce the production of type I interferons, which further promotes the inflammatory response. …”
Publicado 2013
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33168por Kuo, Rei-Lin, Kao, Li-Ting, Lin, Sue-Jane, Wang, Robert Yung-Liang, Shih, Shin-Ru“…Induction of type-I interferons (IFNs), IFN-α/β, is crucial to innate immunity against RNA virus infection. …”
Publicado 2013
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33169por Bloch, Donald B., Li, Pingcheng, Bloch, Emily G., Berenson, Daniel F., Galdos, Rita L., Arora, Pankaj, Malhotra, Rajeev, Wu, Connie, Yang, Weihong“…LMKB was expressed in human B and T lymphocyte cell lines; depletion of LMKB increased expression of IFI44L, a gene that has been implicated in the cellular response to Type I interferons. The interaction between LMKB/MARF1, a protein that contains RNA-binding domains, and Ge-1, which interacts with core-decapping proteins, suggests that LMKB has a role in the regulation of mRNA stability. …”
Publicado 2014
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33170“…These pathways lead to the activation of type I interferons and resistance to infection. In contrast to TLRs, very few studies have examined the role of NOD-like receptors in viral recognition and induction of adaptive immune responses to RSV. …”
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33171“…These actions induce the expression of antiviral gene products and the production of type I and III interferons that lead to an antiviral state in the infected cell and surrounding tissue. …”
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33172por Matsumoto, Takahiro, Matsushima, Yuki, Toda, Masaaki, Roeen, Ziaurahman, D’Alessandro-Gabazza, Corina N, Hinneh, Josephine A, Harada, Etsuko, Yasuma, Taro, Yano, Yutaka, Urawa, Masahito, Kobayashi, Tetsu, Taguchi, Osamu, Gabazza, Esteban C“…RESULTS: Activated protein C significantly increased the differentiation of tolerogenic plasmacytoid dendritic cells and the secretion of type I interferons, but it significantly reduced lipopolysaccharide-mediated maturation and the secretion of inflammatory cytokines in myeloid dendritic cells. …”
Publicado 2015
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33173por Olivry, Thierry, DeBoer, Douglas J., Favrot, Claude, Jackson, Hilary A., Mueller, Ralf S., Nuttall, Tim, Prélaud, Pascal“…The medications currently most effective in reducing chronic pruritus and skin lesions are topical and oral glucocorticoids, oral ciclosporin, oral oclacitinib, and, where available, injectable recombinant interferons. Allergen-specific immunotherapy and proactive intermittent topical glucocorticoid applications are the only interventions likely to prevent or delay the recurrence of flares of AD. …”
Publicado 2015
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33174por Kim, Hun Sik, Kim, Dong Chan, Kim, Hong-Mi, Kwon, Hyung-Joon, Kwon, Soon Jae, Kang, Suk-Jo, Kim, Sun Chang, Choi, Go-Eun“…Interferons (IFNs) potentiate macrophage activation typically via a STAT1-dependent pathway. …”
Publicado 2015
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33175por Koning, Ludi, Charlton, Michael R., Pas, Suzan D., Heimbach, Julie K., Osterhaus, Albert DME, Watt, Kymberly D., Janssen, Harry LA, de Knegt, Robert J., van der Eijk, Annemiek A.“…Post-LT HCV treatment with interferons and/or ribavirin may have protected patients against chronic HEV. …”
Publicado 2015
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33176por Morris, Katrina M., Cheng, Yuanyuan, Warren, Wesley, Papenfuss, Anthony T., Belov, Katherine“…RESULTS: We identify and describe 119 cytokines including 40 interleukins, 39 chemokines, 8 interferons, 18 tumour necrosis family cytokines and 14 additional cytokines. …”
Publicado 2015
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33177“…Although the type I interferons (IFN-α and IFN-β) have a critical role in protecting against most viral infections, the cells responsible for IFN production in response to HRV and the relative importance of pattern recognition receptors located in endosomes has not been fully elucidated. …”
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33178por Sisler, Jennifer D., Morgan, Magdalena, Raje, Vidisha, Grande, Rebecca C., Derecka, Marta, Meier, Jeremy, Cantwell, Marc, Szczepanek, Karol, Korzun, William J., Lesnefsky, Edward J., Harris, Thurl E., Croniger, Colleen M., Larner, Andrew C.“…The transcription factor STAT1 plays a central role in orchestrating responses to various pathogens by activating the transcription of nuclear-encoded genes that mediate the antiviral, the antigrowth, and immune surveillance effects of interferons and other cytokines. In addition to regulating gene expression, we report that STAT1 (-/-) mice display increased energy expenditure and paradoxically decreased release of triglycerides from white adipose tissue (WAT). …”
Publicado 2015
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33179por Jackson, Shaun W., Jacobs, Holly M., Arkatkar, Tanvi, Dam, Elizabeth M., Scharping, Nicole E., Kolhatkar, Nikita S., Hou, Baidong, Buckner, Jane H., Rawlings, David J.“…Although both type 1 and type 2 interferons (IFNs) are involved in lupus pathogenesis, their respective impacts on the establishment of autoimmune GCs has not been addressed. …”
Publicado 2016
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33180por Sommer, Andreas F. R., Rivière, Lise, Qu, Bingqian, Schott, Kerstin, Riess, Maximilian, Ni, Yi, Shepard, Caitlin, Schnellbächer, Esther, Finkernagel, Malin, Himmelsbach, Kiyoshi, Welzel, Karin, Kettern, Nadja, Donnerhak, Christian, Münk, Carsten, Flory, Egbert, Liese, Juliane, Kim, Baek, Urban, Stephan, König, Renate“…Furthermore, SAMHD1 was upregulated by type I and II interferons in hepatic cells. These results suggest that SAMHD1 is a relevant restriction factor for HBV and restricts reverse transcription through its dNTPase activity.…”
Publicado 2016
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