-
33221por Bryant, Andrew J., Pham, Ann, Gogoi, Himanshu, Mitchell, Carly R., Pais, Faye, Jin, Lei“…An interferonopathy, characterized by constitutive expression of type I interferons, ultimately manifests as severe autoimmune disease at a young age. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33222por Drajac, Carole, Laubreton, Daphné, Marquant, Quentin, Chottin, Claire, Ferret, Cécile, Bouguyon, Edwige, Schwartz-Cornil, Isabelle, Saveanu, Loredana, Riffault, Sabine, Descamps, Delphyne“…However, the severe bronchiolitis following RSV infection in neonates has been associated with a defect in type I interferons (IFN-I) production, a cytokine produced mainly by alveolar macrophages (AMs) upon RSV infection in adults. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33223por Fagone, Paolo, Mangano, Katia, Di Marco, Roberto, Reyes-Castillo, Zyanya, Muñoz-Valle, José Francisco, Nicoletti, Ferdinando“…In addition, type I interferons (IFNs)-related genes were enriched among the genes negatively correlated to TSPAN32, in SLE plasmablasts. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33224“…Additionally, several host lncRNAs could help the occurrence of viral immune escape by inhibiting type I interferons (IFN-1), while others could up-regulate IFN-1 production to play an antiviral role. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33225por Brandherm, Lukas, Kobaš, Antonio Mario, Klöhn, Mara, Brüggemann, Yannick, Pfaender, Stephanie, Rassow, Joachim, Kreimendahl, Sebastian“…TOM70 is involved in a signaling cascade that ultimately leads to the induction of type I interferons (IFN-I). This cascade depends on the recruitment of Hsp90-bound proteins to the N-terminal domain of TOM70. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33226“…RESULTS: Randomized SPMS trials showed inconsistent results regarding disability progression for beta interferons and negative results for natalizumab. Oral cladribine and ocrelizumab reduced disability progression in relapsing MS but have not been specifically studied in an SPMS population. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33227“…To understand the pathogenesis of PeV-A3 infection in the neuronal system, PeV-A3-mediated cytopathic effects were analyzed in human glioblastoma cells and neuroblastoma cells. PeV-A3 induced interferons and inflammatory cytokine expression in these neuronal cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33228por Mantovani, Stefania, Daga, Sergio, Fallerini, Chiara, Baldassarri, Margherita, Benetti, Elisa, Picchiotti, Nicola, Fava, Francesca, Gallì, Anna, Zibellini, Silvia, Bruttini, Mirella, Palmieri, Maria, Croci, Susanna, Amitrano, Sara, Alaverdian, Diana, Capitani, Katia, Furini, Simone, Mari, Francesca, Meloni, Ilaria, Frullanti, Elisa, Mondelli, Mario U., Renieri, Alessandra“…Toll-like receptors (TLR) are crucial components in the initiation of innate immune responses to a variety of pathogens, triggering the production of pro-inflammatory cytokines and type I and II interferons, which are responsible for innate antiviral responses. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33229por O'Connell, Patrick, Blake, Maja K., Pepelyayeva, Yuliya, Hyslop, Sean, Godbehere, Sarah, Angarita, Ariana M., Pereira-Hicks, Cristiane, Amalfitano, Andrea, Aldhamen, Yasser A.“…Using multiple murine cancer models, we show that Ad-SF7-Fc can induce tumor control via augmentation of innate immunity; specifically, induction of type I interferons and activation of dendritic cells (DCs) and macrophages. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33230por Pacheco, Guillermo Valencia, Nakazawa Ueji, Yumi E., Bello, Julián Ramírez, Barbosa Cobos, Rosa E., Jiménez Becerra, Eduardo D., González Herrera, Lizbeth J., Pérez Mendoza, Gerardo J., Rivero Cárdenas, Nubia A., Angulo Ramírez, Angélica V., López Villanueva, Ricardo F.“…Genes related to the synthesis of interferons such as TLR7 and genetics factors such as single nucleotide polymorphisms (SNPs) or copies number variation (CNV) in the gene have been involved with the development of the disease. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33231por Abolhassani, Hassan, Landegren, Nils, Bastard, Paul, Materna, Marie, Modaresi, Mohammadreza, Du, Likun, Aranda-Guillén, Maribel, Sardh, Fabian, Zuo, Fanglei, Zhang, Peng, Marcotte, Harold, Marr, Nico, Khan, Taushif, Ata, Manar, Al-Ali, Fatima, Pescarmona, Remi, Belot, Alexandre, Béziat, Vivien, Zhang, Qian, Casanova, Jean-Laurent, Kämpe, Olle, Zhang, Shen-Ying, Hammarström, Lennart, Pan-Hammarström, Qiang“…BACKGROUND: Inborn errors of immunity (IEI) and autoantibodies to type I interferons (IFNs) underlie critical COVID-19 pneumonia in at least 15% of the patients, while the causes of multisystem inflammatory syndrome in children (MIS-C) remain elusive. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33232por Thomsen, Emil Aagaard, Andersen, Sofie, Marqvorsen, Mikkel Haarslev Schröder, Skipper, Kristian Alsbjerg, Paludan, Søren R., Mikkelsen, Jacob Giehm“…The innate immune system represents a balanced first line of defense against infection. Type I interferons (IFNs) are key regulators of the response to viral infections with an essential early wave of IFN-β expression, which is conditional, time-restricted, and stochastic in its nature. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33233por Fukuda, Yosuke, Homma, Tetsuya, Inoue, Hideki, Goto, Yuiko, Sato, Yoko, Ikeda, Hitoshi, Onitsuka, Chisato, Sato, Hiroki, Akimoto, Kaho, Ebato, Takaya, Suganuma, Hiromitsu, Kawahara, Tomoko, Mikuni, Hatsuko, Uchida, Yoshitaka, Suzuki, Shintaro, Tanaka, Akihiko, Sagara, Hironori“…Type III interferons (IFNs) play an important role in respiratory viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33234por Pushparaj, Samuel, Zhu, Zhengyu, Huang, Chaoqun, More, Sunil, Liang, Yurong, Lin, Kong, Vaddadi, Kishore, Liu, Lin“…This lncRNA was predominantly located in the nucleus and was not affected by type I interferons. Overexpression of Lnc‐PINK1‐2:5 reduced the influenza viral mRNA and protein levels in cells as well as titres in culture media. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33235por Zhao, Yuyue, Pan, Yuanwei, Zou, Kelong, Lan, Zhou, Cheng, Guowang, Mai, Qiuying, Cui, Hao, Meng, Qianfang, Chen, Tongkai, Rao, Lang, Ma, Limin, Yu, Guangtao“…In cancer cells, Mn(2+) catalyzes H(2)O(2) into ·OH for (chemodynamic therapy) CDT leading to activate cGAS-STING, but also directly acts on STING inducing secretion of type I interferons, pro-inflammatory cytokines and chemokines. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33236por Kassianidis, Georgios, Siampanos, Athanasios, Poulakou, Garyphalia, Adamis, George, Rapti, Aggeliki, Milionis, Haralampos, Dalekos, George N., Petrakis, Vasileios, Sympardi, Styliani, Metallidis, Symeon, Alexiou, Zoi, Gkavogianni, Theologia, Giamarellos-Bourboulis, Evangelos J., Theoharides, Theoharis C.“…We determined serum levels within 24 h of presentation of 20 different sets of mediators (calprotectin, pro- and anti-inflammatory cytokines, interferons) of patients with COVID-19 at different stages of severity (asymptomatic, moderate, severe and ARDS/MV). …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33237“…Multiple cellular sensors that detect viral components can induce innate antiviral immune responses. As a result, interferons and pro-inflammatory cytokines are produced which help in the elimination of invading viruses. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33238por Detsika, Maria G., Nikitopoulou, Ioanna, Veroutis, Dimitris, Vassiliou, Alice G., Jahaj, Edison, Tsipilis, Stamatis, Athanassiou, Nikolaos, Gakiopoulou, Hariklia, Gorgoulis, Vassilis G., Dimopoulou, Ioanna, Orfanos, Stylianos E., Kotanidou, Anastasia“…Heme-oxygenase (HO)-1 is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties and previous reports have also emphasized the antiviral properties of HO-1, either directly or via induction of interferons. To investigate the potential role of HO-1 in patients with coronavirus disease 2019 (COVID-19), the present study assessed changes in HO-1 expression in whole blood and tissue samples. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33239por Li, Zhi, Wang, Jianghua, Chen, Chong, He, Qi, Xu, Xiaoying, Da, Zejiao, Wang, Bo, Wang, Meng, Gao, Xiaotong, Zhang, Guochao, Gao, Qi, Si, Xiaoli, Luo, Yanping, Ma, Xingming“…IL-28B, belonging to type III interferons (IFN-λs), exhibits a potent antitumor activity with reduced regulated T cells (Tregs) population, yet the effect of IL-28B on the tumor microenvironment (TME) and if IL-28B can downregulate Tregs directly in vitro are still unknown. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33240por Silva, Marcos Jessé Abrahão, Rodrigues, Yan Corrêa, Lima, Karla Valéria Batista, Lima, Luana Nepomuceno Gondim Costa“…The innate immune response through the generation of interferons, alternative pathways and complement system lectins and the joint action of innate immune cells and cytokines and chemokines lead to different clinical outcomes, taking into account the exacerbated inflammatory response and pathogenesis. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto