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  1. 33241
    por Zhang, Qian, Pizzorno, Andrés, Miorin, Lisa, Bastard, Paul, Gervais, Adrian, Le Voyer, Tom, Bizien, Lucy, Manry, Jeremy, Rosain, Jérémie, Philippot, Quentin, Goavec, Kelian, Padey, Blandine, Cupic, Anastasija, Laurent, Emilie, Saker, Kahina, Vanker, Martti, Särekannu, Karita, García-Salum, Tamara, Ferres, Marcela, Le Corre, Nicole, Sánchez-Céspedes, Javier, Balsera-Manzanero, María, Carratala, Jordi, Retamar-Gentil, Pilar, Abelenda-Alonso, Gabriela, Valiente, Adoración, Tiberghien, Pierre, Zins, Marie, Debette, Stéphanie, Meyts, Isabelle, Haerynck, Filomeen, Castagnoli, Riccardo, Notarangelo, Luigi D., Gonzalez-Granado, Luis I., Dominguez-Pinilla, Nerea, Andreakos, Evangelos, Triantafyllia, Vasiliki, Rodríguez-Gallego, Carlos, Solé-Violán, Jordi, Ruiz-Hernandez, José Juan, Rodríguez de Castro, Felipe, Ferreres, José, Briones, Marisa, Wauters, Joost, Vanderbeke, Lore, Feys, Simon, Kuo, Chen-Yen, Lei, Wei-Te, Ku, Cheng-Lung, Tal, Galit, Etzioni, Amos, Hanna, Suhair, Fournet, Thomas, Casalegno, Jean-Sebastien, Queromes, Gregory, Argaud, Laurent, Javouhey, Etienne, Rosa-Calatrava, Manuel, Cordero, Elisa, Aydillo, Teresa, Medina, Rafael A., Kisand, Kai, Puel, Anne, Jouanguy, Emmanuelle, Abel, Laurent, Cobat, Aurélie, Trouillet-Assant, Sophie, García-Sastre, Adolfo, Casanova, Jean-Laurent
    Publicado 2022
    “…Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. …”
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    Autoantibodies against type I IFNs in patients with critical influenza pneumonia
  2. 33242
    “…Cytokine-mediated signaling can modulate immune function; thus, understanding the cytokine milieu in granulomas is critical for understanding immunity in tuberculosis (TB). Interferons (IFNs) are important immune mediators in TB, and while type 1 and 2 IFNs have been extensively studied, less is known about type 3 IFNs (IFNλs) in TB. …”
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    Macrophages and neutrophils express IFNλs in granulomas from Mycobacterium tuberculosis-infected nonhuman primates
  3. 33243
    “…The results of proteomics screening suggested an association between FAdV-4 infection and Notch signaling in LMH in vitro, indicating that Notch signaling regulated the expression of inflammatory cytokines and interferons but not viral replication in LMH cells. …”
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    TMT-based quantitative proteomics analysis reveals the role of Notch signaling in FAdV-4-infected LMH cell
  4. 33244
    por Zhang, Yiqun, Lan, Shijie, Wu, Di
    Publicado 2022
    “…Anti-angiogenic drugs, albumin paclitaxel, or interferons are thought to enhance the effectiveness of immune checkpoint inhibitors. …”
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    Advanced Acral Melanoma Therapies: Current Status and Future Directions
  5. 33245
    “…Type I interferons (IFN), including IFNβ, play a protective role in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). …”
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    Targeting Signaling Pathway Downstream of RIG-I/MAVS in the CNS Stimulates Production of Endogenous Type I IFN and Suppresses EAE
  6. 33246
    “…Sjӧgren’s syndrome (SS) is a systemic autoimmune disease that targets the exocrine glands, resulting in impaired saliva and tear secretion. To date, type I interferons (I-IFNs) are increasingly recognized as pivotal mediators in SS, but their endogenous drivers have not been elucidated. …”
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    Mitochondrial double-stranded RNAs as a pivotal mediator in the pathogenesis of Sjӧgren’s syndrome
  7. 33247
    por Marrocco, Antonella, Ortiz, Luis A.
    Publicado 2022
    “…Silica-stimulated macrophages activate pattern recognition receptors (PRRs) and NLRP3 inflammasome and release IL-1β, TNF-α, and interferons, which are the key mediators of silicosis pathogenesis. …”
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    Role of metabolic reprogramming in pro-inflammatory cytokine secretion from LPS or silica-activated macrophages
  8. 33248
    “…The precise mechanism of pleuropulmonary involvement in SLE is not well-understood; however, systemic type 1 interferons, circulating immune complexes, and neutrophils seem to play essential roles. …”
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    Systemic Lupus Erythematosus and Lung Involvement: A Comprehensive Review
  9. 33249
    “…Upon TLR7 stimulation, dendritic cells (DC) mediate the production of inflammatory cytokines, and in particular of type I interferons (IFN). Especially in DCs, IRF5 is a key transcription factor that regulates pathogen-induced immune responses via activation of the MyD88-dependent TLR signaling pathway. …”
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    Frequency of IRF5+ dendritic cells is associated with the TLR7-induced inflammatory cytokine response in SARS-CoV-2 infection
  10. 33250
    “…Furthermore, high levels of significant concordance between mouse and human were seen for immune pathways and signatures, which were dominated by interferons, T cells and monocyte/macrophages. Importantly, predicted responses to a series of anti-inflammatory drug and biologic treatments also showed cogent similarities between species. …”
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    Chikungunya patient transcriptional signatures faithfully recapitulated in a C57BL/6J mouse model
  11. 33251
    “…Here, HBVx (HBx) mRNA expression and HBV replication were significantly inhibited, followed by the enhancement of expression of type I interferons (IFNs), IFN-stimulated genes (ISG15 and ISG56) and proinflammatory cytokines after HepG2.2.15 cells were transfected with chemically synthesized HBx-siRNAs. …”
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    Involvement of Activation of PKR in HBx-siRNA-Mediated Innate Immune Effects on HBV Inhibition
  12. 33252
    “…We demonstrated that morphine treatment of human blood monocyte-derived macrophages significantly inhibited the expression of interferons (IFN-α, IFN-β and IFN-λ) and IFN-inducible genes (APOBEC3C/3F/3G and 3H). …”
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    Morphine Suppresses IFN Signaling Pathway and Enhances AIDS Virus Infection
  13. 33253
    “…The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of infected cells and activate signal transduction pathways that trigger the production of type I interferons (IFNs). Laboratory of genetics and physiology 2 (LGP2) is thought to influence IFN production by regulating the activity of RIG-I and mda-5, although its mechanism of action is not known and its function is controversial. …”
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    LGP2 Plays a Critical Role in Sensitizing mda-5 to Activation by Double-Stranded RNA
  14. 33254
    por Gallo, Paul M., Gallucci, Stefania
    Publicado 2013
    “…Others are actively secreted, like Type I Interferons. Here we discuss important DAMPs in the context of autoimmunity. …”
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    The Dendritic Cell Response to Classic, Emerging, and Homeostatic Danger Signals. Implications for Autoimmunity
  15. 33255
    “…The major limitation of the clinical use of replication-incompetent adenovirus (Ad) vectors is the interference by innate immune responses, including induction of inflammatory cytokines and interferons (IFN), following in vivo application of Ad vectors. …”
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    Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses
  16. 33256
    por Kim, Tae Hyun, Zhou, Huaijun
    Publicado 2015
    “…In order to develop novel strategies to protect against increasingly virulent bird-linked pathogens, a better understanding of the avian antiviral response mechanism is essential. Type I interferons (IFNs) are recognized as the first line of defense in a host’s antiviral response; and it has been suggested that IRF7, a member of the IFN regulatory factor (IRF) family, plays an important role in modulating the immune response to avian influenza virus infection in chickens. …”
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    Functional Analysis of Chicken IRF7 in Response to dsRNA Analog Poly(I:C) by Integrating Overexpression and Knockdown
  17. 33257
    por Smith, Judith A.
    Publicado 2018
    “…Cytokines (inflammatory cytokines and interferons) critically mediate host defense against pathogens, but when aberrantly produced, may also drive pathologic inflammation. …”
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    Regulation of Cytokine Production by the Unfolded Protein Response; Implications for Infection and Autoimmunity
  18. 33258
    “…Stimulation with poly(I:C) increased IFN-α and IFN-β mRNA expression in injured cells, and LPS stimulation decreased interferons mRNA expression both in not-injured and injured ECs. …”
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    Toll-Like Receptor Agonists Modulate Wound Regeneration in Airway Epithelial Cells
  19. 33259
    “…Also, a significantly different immune response to virus infection (protein IFI16, interferons gamma and beta, dendritic cells, and receptor for natural killers) was revealed in the minor salivary glands of the study groups. …”
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    Sjögren's Syndrome: Concerted Triggering of Sicca Conditions
  20. 33260
    “…Both mutants induced VN antibodies and interferons after immunization. In addition, after challenge infection, we observed a reduction of IL-1β expression, and modulation of TNFα, TGFβ and IL10 expression. …”
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    Safety and Efficacy of Felid Herpesvirus-1 Deletion Mutants in Cats
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