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33241por Zhang, Qian, Pizzorno, Andrés, Miorin, Lisa, Bastard, Paul, Gervais, Adrian, Le Voyer, Tom, Bizien, Lucy, Manry, Jeremy, Rosain, Jérémie, Philippot, Quentin, Goavec, Kelian, Padey, Blandine, Cupic, Anastasija, Laurent, Emilie, Saker, Kahina, Vanker, Martti, Särekannu, Karita, García-Salum, Tamara, Ferres, Marcela, Le Corre, Nicole, Sánchez-Céspedes, Javier, Balsera-Manzanero, María, Carratala, Jordi, Retamar-Gentil, Pilar, Abelenda-Alonso, Gabriela, Valiente, Adoración, Tiberghien, Pierre, Zins, Marie, Debette, Stéphanie, Meyts, Isabelle, Haerynck, Filomeen, Castagnoli, Riccardo, Notarangelo, Luigi D., Gonzalez-Granado, Luis I., Dominguez-Pinilla, Nerea, Andreakos, Evangelos, Triantafyllia, Vasiliki, Rodríguez-Gallego, Carlos, Solé-Violán, Jordi, Ruiz-Hernandez, José Juan, Rodríguez de Castro, Felipe, Ferreres, José, Briones, Marisa, Wauters, Joost, Vanderbeke, Lore, Feys, Simon, Kuo, Chen-Yen, Lei, Wei-Te, Ku, Cheng-Lung, Tal, Galit, Etzioni, Amos, Hanna, Suhair, Fournet, Thomas, Casalegno, Jean-Sebastien, Queromes, Gregory, Argaud, Laurent, Javouhey, Etienne, Rosa-Calatrava, Manuel, Cordero, Elisa, Aydillo, Teresa, Medina, Rafael A., Kisand, Kai, Puel, Anne, Jouanguy, Emmanuelle, Abel, Laurent, Cobat, Aurélie, Trouillet-Assant, Sophie, García-Sastre, Adolfo, Casanova, Jean-Laurent“…Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. …”
Publicado 2022
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33242por Talukdar, Priyanka, Junecko, Beth F., Lane, Daniel S., Maiello, Pauline, Mattila, Joshua T.“…Cytokine-mediated signaling can modulate immune function; thus, understanding the cytokine milieu in granulomas is critical for understanding immunity in tuberculosis (TB). Interferons (IFNs) are important immune mediators in TB, and while type 1 and 2 IFNs have been extensively studied, less is known about type 3 IFNs (IFNλs) in TB. …”
Publicado 2022
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33243“…The results of proteomics screening suggested an association between FAdV-4 infection and Notch signaling in LMH in vitro, indicating that Notch signaling regulated the expression of inflammatory cytokines and interferons but not viral replication in LMH cells. …”
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33244“…Anti-angiogenic drugs, albumin paclitaxel, or interferons are thought to enhance the effectiveness of immune checkpoint inhibitors. …”
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33245por Kronborg Hansen, Anne K., Dubik, Magdalena, Marczynska, Joanna, Ojha, Bhavya, Nistal-Villán, Estanislao, González Aseguinolaza, Gloria, Arengoth, Dina S., Owens, Trevor, Khorooshi, Reza“…Type I interferons (IFN), including IFNβ, play a protective role in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). …”
Publicado 2022
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33246por Yoon, Jimin, Lee, Minseok, Ali, Ahsan Ausaf, Oh, Ye Rim, Choi, Yong Seok, Kim, Sujin, Lee, Namseok, Jang, Se Gwang, Park, Seonghyeon, Chung, Jin-Haeng, Kwok, Seung-Ki, Hyon, Joon Young, Cha, Seunghee, Lee, Yun Jong, Im, Sung Gap, Kim, Yoosik“…Sjӧgren’s syndrome (SS) is a systemic autoimmune disease that targets the exocrine glands, resulting in impaired saliva and tear secretion. To date, type I interferons (I-IFNs) are increasingly recognized as pivotal mediators in SS, but their endogenous drivers have not been elucidated. …”
Publicado 2022
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33247“…Silica-stimulated macrophages activate pattern recognition receptors (PRRs) and NLRP3 inflammasome and release IL-1β, TNF-α, and interferons, which are the key mediators of silicosis pathogenesis. …”
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33248por Shin, Jae Il, Lee, Keum Hwa, Park, Seoyeon, Yang, Jae Won, Kim, Hyung Ju, Song, Kwanhyuk, Lee, Seungyeon, Na, Hyeyoung, Jang, Yong Jun, Nam, Ju Yun, Kim, Soojin, Lee, Chaehyun, Hong, Chanhee, Kim, Chohwan, Kim, Minhyuk, Choi, Uichang, Seo, Jaeho, Jin, Hyunsoo, Yi, BoMi, Jeong, Se Jin, Sheok, Yeon Ook, Kim, Haedong, Lee, Sangmin, Lee, Sangwon, Jeong, Young Soo, Park, Se Jin, Kim, Ji Hong, Kronbichler, Andreas“…The precise mechanism of pleuropulmonary involvement in SLE is not well-understood; however, systemic type 1 interferons, circulating immune complexes, and neutrophils seem to play essential roles. …”
Publicado 2022
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33249por Cords, Leon, Woost, Robin, Kummer, Silke, Brehm, Thomas T., Kluge, Stefan, Schmiedel, Stefan, Jordan, Sabine, Lohse, Ansgar W., Altfeld, Marcus, Addo, Marylyn M., Schulze zur Wiesch, Julian, Beisel, Claudia“…Upon TLR7 stimulation, dendritic cells (DC) mediate the production of inflammatory cytokines, and in particular of type I interferons (IFN). Especially in DCs, IRF5 is a key transcription factor that regulates pathogen-induced immune responses via activation of the MyD88-dependent TLR signaling pathway. …”
Publicado 2023
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33250“…Furthermore, high levels of significant concordance between mouse and human were seen for immune pathways and signatures, which were dominated by interferons, T cells and monocyte/macrophages. Importantly, predicted responses to a series of anti-inflammatory drug and biologic treatments also showed cogent similarities between species. …”
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33251“…Here, HBVx (HBx) mRNA expression and HBV replication were significantly inhibited, followed by the enhancement of expression of type I interferons (IFNs), IFN-stimulated genes (ISG15 and ISG56) and proinflammatory cytokines after HepG2.2.15 cells were transfected with chemically synthesized HBx-siRNAs. …”
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33252por Wang, Yizhong, Wang, Xu, Ye, Li, Li, Jieliang, Song, Li, Fulambarkar, Nilija, Ho, Wenzhe“…We demonstrated that morphine treatment of human blood monocyte-derived macrophages significantly inhibited the expression of interferons (IFN-α, IFN-β and IFN-λ) and IFN-inducible genes (APOBEC3C/3F/3G and 3H). …”
Publicado 2012
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33253“…The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of infected cells and activate signal transduction pathways that trigger the production of type I interferons (IFNs). Laboratory of genetics and physiology 2 (LGP2) is thought to influence IFN production by regulating the activity of RIG-I and mda-5, although its mechanism of action is not known and its function is controversial. …”
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33254“…Others are actively secreted, like Type I Interferons. Here we discuss important DAMPs in the context of autoimmunity. …”
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33255por Machitani, Mitsuhiro, Yamaguchi, Tomoko, Shimizu, Kahori, Sakurai, Fuminori, Katayama, Kazufumi, Kawabata, Kenji, Mizuguchi, Hiroyuki“…The major limitation of the clinical use of replication-incompetent adenovirus (Ad) vectors is the interference by innate immune responses, including induction of inflammatory cytokines and interferons (IFN), following in vivo application of Ad vectors. …”
Publicado 2011
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33256“…In order to develop novel strategies to protect against increasingly virulent bird-linked pathogens, a better understanding of the avian antiviral response mechanism is essential. Type I interferons (IFNs) are recognized as the first line of defense in a host’s antiviral response; and it has been suggested that IRF7, a member of the IFN regulatory factor (IRF) family, plays an important role in modulating the immune response to avian influenza virus infection in chickens. …”
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33257por Smith, Judith A.“…Cytokines (inflammatory cytokines and interferons) critically mediate host defense against pathogens, but when aberrantly produced, may also drive pathologic inflammation. …”
Publicado 2018
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33258por Lewandowska-Polak, Anna, Brauncajs, Małgorzata, Jarzębska, Marzanna, Pawełczyk, Małgorzata, Kurowski, Marcin, Chałubiński, Maciej, Makowska, Joanna, Kowalski, Marek L.“…Stimulation with poly(I:C) increased IFN-α and IFN-β mRNA expression in injured cells, and LPS stimulation decreased interferons mRNA expression both in not-injured and injured ECs. …”
Publicado 2018
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33259por Mackiewicz, Zygmunt, Mażul, Justyna, Narkevičiūtė, Ieva, Dumalakienė, Irena, Butrimienė, Irena, Vilienė, Rita, Stankevičienė, Indrė, Mieliauskaitė, Diana“…Also, a significantly different immune response to virus infection (protein IFI16, interferons gamma and beta, dendritic cells, and receptor for natural killers) was revealed in the minor salivary glands of the study groups. …”
Publicado 2019
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33260por Lee, Yao, Maes, Roger K., Kruger, John M., Kiupel, Matti, Giessler, Kim S., Soboll Hussey, Gisela“…Both mutants induced VN antibodies and interferons after immunization. In addition, after challenge infection, we observed a reduction of IL-1β expression, and modulation of TNFα, TGFβ and IL10 expression. …”
Publicado 2021
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