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33281por Johnson, Kenneth P“…Outcomes in the primary endpoints of these trials showed no significant differences between GA and high-dose beta-interferons (IFNβs). Results of the PreCISe (Early GA Treatment in Delaying Conversion to Clinically Definite Multiple Sclerosis [CDMS] in Subjects Presenting With a Clinically Isolated Syndrome [CIS]) trial led to the US Food and Drug Administration approval of GA in patients with a CIS. …”
Publicado 2010
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33282por Michaud, François, Coulombe, François, Gaudreault, Eric, Paquet-Bouchard, Carine, Rola-Pleszczynski, Marek, Gosselin, Jean“…Evidence suggests that monocytes are likely to be involved in EBV pathogenesis, especially due to a number of cellular functions altered in EBV-infected monocytes, a process that may affect efficient host defense. Because type I interferons (IFNs) are crucial mediators of host defense against viruses, we investigated the effect of EBV infection on the IFNα pathway in primary human monocytes. …”
Publicado 2010
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33283por Kubarenko, Andriy V., Ranjan, Satish, Rautanen, Anna, Mills, Tara C., Wong, Sunny, Vannberg, Fredrik, Neumaier, Michael, Bekeredjian-Ding, Isabelle, Hill, Adrian V. S., Ahmad-Nejad, Parviz, Weber, Alexander N. R.“…TLR9 activation leads to the production of interferons and the priming of humoral adaptive immune responses. …”
Publicado 2010
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33284“…Activated PRRs deliver signals to adaptor molecules (MyD88, TRIF, MAL/TIRAP, TRAM, IPS-1) which act as important messengers to activate downstream kinases (IKK complex, MAPKs, TBK1, RIP-1) and transcription factors (NF-κB, AP-1, IRF3), which produce effecter molecules including cytokines, chemokines, inflammatory enzymes, and type I interferones. Since excessive PRR activation is closely linked to the development of chronic inflammatory diseases, the role of intrinsic and extrinsic regulators in the prevention of over- or unnecessary activation of PRRs has been widely studied. …”
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33285por Rodriguez Rodrigues, Christian, Cabrini, Mercedes, Remes Lenicov, Federico, Sabatté, Juan, Ceballos, Ana, Jancic, Carolina, Raiden, Silvina, Ostrowski, Matías, Silberstein, Claudia, Geffner, Jorge“…Plasmacytoid dendritic cells (pDCs) play a major role in anti-viral immunity by virtue of their ability to produce high amounts of type I interferons (IFNs) and a variety of inflammatory cytokines and chemokines in response to viral infections. …”
Publicado 2011
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33286“…On the other hand, the same antibodies, together with antibodies against type I interferons may prevent the patients from other immunological diseases, such as psoriasis and systemic lupus erythematous. …”
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33287por Tian, Xiaoli, Xu, Feng, Lung, Wing Yi, Meyerson, Cherise, Ghaffari, Amir Ali, Cheng, Genhong, Deng, Jane C.“…Finally, we determined that poly I:C administration resulted in significant induction of type I interferons (IFNs), whereas the elimination of type I IFN signaling improved clearance and survival following secondary bacterial pneumonia. …”
Publicado 2012
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33288“…Type I interferons (IFN) have been shown to play an important role for inhibiting Dengue virus (DENV) infection. …”
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33289por Spencer, Charles T., Abate, Getahun, Sakala, Isaac G., Xia, Mei, Truscott, Steven M., Eickhoff, Christopher S., Linn, Rebecca, Blazevic, Azra, Metkar, Sunil S., Peng, Guangyong, Froelich, Christopher J., Hoft, Daniel F.“…The inhibitory mechanism was independent of autophagy, apoptosis, nitric oxide production, type I interferons, Fas/FasL and perforin. These results demonstrate a novel microbial defense mechanism involving granzyme A-mediated triggering of TNF-α production by monocytes leading to intracellular mycobacterial growth suppression. …”
Publicado 2013
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33290por Renga, Barbara, Mencarelli, Andrea, Cipriani, Sabrina, D'Amore, Claudio, Carino, Adriana, Bruno, Angela, Francisci, Daniela, Zampella, Angela, Distrutti, Eleonora, Fiorucci, Stefano“…In addition to its role in regulating type-I interferons and innate antiviral immunity, IRF-7 a TLR9-dependent factor, regulates the expression of FXR, linking microbiota-sensing receptors to host's immune and metabolic signaling.…”
Publicado 2013
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33291por Högner, Katrin, Wolff, Thorsten, Pleschka, Stephan, Plog, Stephanie, Gruber, Achim D., Kalinke, Ulrich, Walmrath, Hans-Dieter, Bodner, Johannes, Gattenlöhner, Stefan, Lewe-Schlosser, Peter, Matrosovich, Mikhail, Seeger, Werner, Lohmeyer, Juergen, Herold, Susanne“…Dysregulated release of cytokines including type I interferons (IFNs) has been attributed a crucial role in immune-mediated pulmonary injury during severe IV infection. …”
Publicado 2013
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33292“…Type-I interferons (IFNs) form a large family of cytokines that primarily act to control the early development of viral infections. …”
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33293“…Signaling by cytokines such as the interferons (IFNs) involves Janus kinases (JAKs) and signal transducer and activator of transcription (STAT) transcription factors. …”
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33294“…We find that the mRNA and protein levels of Tetherin in macrophages are comparable to those in T cells from the same donors, and are highly upregulated by type I interferons. Improved immunocytochemistry protocols enable us to demonstrate that Tetherin localises to the cell surface, the trans-Golgi network, and the macrophage HIV assembly compartments. …”
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33295por Goubau, Delphine, Schlee, Martin, Deddouche, Safia, Pruijssers, Andrea J., Zillinger, Thomas, Goldeck, Marion, Schuberth, Christine, Van der Veen, Annemarthe G., Fujimura, Tsutomu, Rehwinkel, Jan, Iskarpatyoti, Jason A., Barchet, Winfried, Ludwig, Janos, Dermody, Terence S., Hartmann, Gunther, Reis e Sousa, Caetano“…Detection triggers a signalling cascade via the adaptor MAVS that culminates in the production of type I interferons (IFN-α/β; hereafter IFN), key antiviral cytokines. …”
Publicado 2014
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33296por Mahlakõiv, Tanel, Hernandez, Pedro, Gronke, Konrad, Diefenbach, Andreas, Staeheli, Peter“…Viral infections induce simultaneous production of type I (IFN-α/β) and type III (IFN-λ) interferons. All nucleated cells are believed to respond to IFN-α/β, whereas IFN-λ responses are largely confined to epithelial cells. …”
Publicado 2015
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33297“…Mechanistically, ATG5 protein interacted with retinoic acid-inducible gene I (RIG-I) and IFN-β promoter stimulator 1 (IPS-1), two critical molecules involved in the expression of anti-viral interferons. Our results suggest that induction of autophagy in human primary airway epithelial cells inhibits the anti-viral IFN-λ1 expression and facilitates HRV infection. …”
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33298“…The effects of interferons (IFN) on in vitro differentiation of B-lymphocytes were studied. …”
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33299“…In addition, the expression of several chemokine- and cytokine-encoding genes, which are related to Th2 and T(reg) cell mediated immune responses, were analyzed in mouse embryonic fibroblasts (MEFs) isolated from myeloid differentiation factor 88 (MyD88)/TIR-associated proteins (TIRAP) and Toll receptor-associated activator of interferons (TRIF) adapter protein deficient and wild type (WT) mice. …”
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33300por van der Lee, Robin, Feng, Qian, Langereis, Martijn A., ter Horst, Rob, Szklarczyk, Radek, Netea, Mihai G., Andeweg, Arno C., van Kuppeveld, Frank J. M., Huynen, Martijn A.“…The RIG-I-like receptor (RLR) pathway is essential for detecting cytosolic viral RNA to trigger the production of type I interferons (IFNα/β) that initiate an innate antiviral response. …”
Publicado 2015
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