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33361“…It has been further proposed that ZAP activity shapes compositions of cytoplasmic mRNA sequences to avoid self-recognition, particularly mRNAs for interferons (IFNs) and IFN-stimulated genes (ISGs) expressed during the antiviral state. …”
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33362por Nakata, Yoshihiro, Ode, Hirotaka, Kubota, Mai, Kasahara, Takaaki, Matsuoka, Kazuhiro, Sugimoto, Atsuko, Imahashi, Mayumi, Yokomaku, Yoshiyuki, Iwatani, Yasumasa“…Interestingly, A3A mRNA expression was drastically increased by interferons (IFNs) and tumour necrosis factor-α (TNF-α) in epithelial cells derived from the respiratory system, a site of efficient SARS-CoV-2 replication. …”
Publicado 2023
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33363por Lacasse, Émile, Gudimard, Leslie, Dubuc, Isabelle, Gravel, Annie, Allaeys, Isabelle, Boilard, Éric, Flamand, Louis“…K18-hACE2 mice were infected with a Wuhan-like strain of SARS-CoV-2, and the transcriptional and translational expression interferons (IFNs), cytokines, and chemokines were analyzed in mouse lung homogenates. …”
Publicado 2023
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33364“…Coronavirus infection induces a variety of cellular antiviral responses either dependent on or independent of type I interferons (IFNs). Our previous studies using Affymetrix microarray and transcriptomic analysis revealed the differential induction of three IFN-stimulated genes (ISGs), IRF1, ISG15 and ISG20, by gammacoronavirus infectious bronchitis virus (IBV) infection of IFN-deficient Vero cells and IFN-competent, p53-defcient H1299 cells, respectively. …”
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33365por Wirz, Oliver F., Jansen, Kirstin, Satitsuksanoa, Pattraporn, van de Veen, Willem, Tan, Ge, Sokolowska, Milena, Mirer, David, Stanić, Barbara, Message, Simon D., Kebadze, Tatiana, Glanville, Nicholas, Mallia, Patrick, Gern, James E., Papadopoulos, Nikolaos, Akdis, Cezmi A., Johnston, Sebastian L., Nadeau, Kari, Akdis, Mübeccel“…While B cells lacked expression of interferons in response to rhinovirus exposure, co‐stimulation with rhinovirus and IFN‐alpha upregulated pro‐inflammatory cytokine expression suggesting a potential new function of B cells during virus infections. …”
Publicado 2021
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33366por Felis-Giemza, Anna, Massalska, Magdalena, Roszkowski, Leszek, Romanowska-Próchnicka, Katarzyna, Ciechomska, Marzena“…Abnormal production of pro-inflammatory cytokines such as interleukin-6 (IL-6), interferons (IFNs), granulocyte-macrophage colony-stimulating factor (GM-CSF), TNF, IL-15, IL-17 play a role in both IRDs and subsequent fatigue development. …”
Publicado 2023
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33367por Pecori, Chiara, Giannini, Marta, Portaccio, Emilio, Ghezzi, Angelo, Hakiki, Bahia, Pastò, Luisa, Razzolini, Lorenzo, Sturchio, Andrea, De Giglio, Laura, Pozzilli, Carlo, Paolicelli, Damiano, Trojano, Maria, Marrosu, Maria Giovanna, Patti, Francesco, Mancardi, Gian Luigi, Solaro, Claudio, Totaro, Rocco, Tola, Maria Rosaria, De Luca, Giovanna, Lugaresi, Alessandra, Moiola, Lucia, Martinelli, Vittorio, Comi, Giancarlo, Amato, Maria Pia“…Forty-five patients were taking DMD at time of conception (39 beta-interferons, 6 glatiramer acetate), while 33 pregnancies were unexposed to DMD. …”
Publicado 2014
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33368por Tomasello, Elena, Pollet, Emeline, Vu Manh, Thien-Phong, Uzé, Gilles, Dalod, Marc“…Type I interferons (IFN-I) were identified over 50 years ago as cytokines critical for host defense against viral infections. …”
Publicado 2014
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33369por Pellerin, Alex, Otero, Karel, Czerkowicz, Julie M, Kerns, Hannah M, Shapiro, Renée I, Ranger, Ann M, Otipoby, Kevin L, Taylor, Frederick R, Cameron, Thomas O, Viney, Joanne L, Rabah, Dania“…Type I interferons (IFN-I) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). …”
Publicado 2015
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33370por Chen, Shilong, Luo, Guifeng, Yang, Zhou, Lin, Shuncheng, Chen, Shaoying, Wang, Song, Goraya, Mohsan Ullah, Chi, Xiaojuan, Zeng, Xiancheng, Chen, Ji-Long“…In this study, we found that ATMUV infection significantly up-regulated the expression of type I and type III interferons (IFN) and some critical IFN-stimulated genes (ISG) in vivo and in vitro. …”
Publicado 2016
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33371por Cao, Zhongying, Xia, Zhangchuan, Zhou, Yaqin, Yang, Xiaodan, Hao, Hua, Peng, Nanfang, Liu, Shi, Zhu, Ying“…MAVS then recruits the adaptor’s tumor necrosis factor receptor-associated factor (TRAF) 3 and TRAF6, which in turn activate IRF3 and NF-κB, respectively, to induce interferons (IFNs) and inflammatory responses. Here we show that the biotin-containing enzyme methylcrotonoyl-CoA carboxylase 1 (MCCC1) enhances virus-induced, MAVS-mediated IFN and inflammatory cytokine expression through the NF-κB signaling pathway. …”
Publicado 2016
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33372por Marques, Rafael Elias, Del Sarto, Juliana L., Rocha, Rebeca P. F., Gomes, Giovanni F., Cramer, Allysson, Rachid, Milene A., Souza, Danielle G., Nogueira, Maurício L., Teixeira, Mauro M.“…Infection was characterized by the production of proinflammatory cytokines and interferons and by leukocyte recruitment to the brain, composed mainly by neutrophils and lymphocytes. …”
Publicado 2017
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33373por Thaney, Victoria E., O’Neill, Alan M., Hoefer, Melanie M., Maung, Ricky, Sanchez, Ana B., Kaul, Marcus“…Infection with human immunodeficiency virus-1 (HIV-1) causes brain injury. Type I interferons (IFNα/β) are critical mediators of any anti-viral immune response and IFNβ has been implicated in the temporary control of lentiviral infection in the brain. …”
Publicado 2017
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33374por Tang, Yan, Wang, Zuocheng, Yang, JungWoo, Zheng, Wang, Chen, Di, Wu, Guanqing, Sandford, Richard, Tang, Jingfeng, Chen, Xing-Zhen“…PKR is known to be activated by interferons and dsRNAs, inhibits protein synthesis and induces apoptosis. …”
Publicado 2017
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33375por Beshara, Ranin, Sencio, Valentin, Soulard, Daphnée, Barthélémy, Adeline, Fontaine, Josette, Pinteau, Thibault, Deruyter, Lucie, Ismail, Mohamad Bachar, Paget, Christophe, Sirard, Jean-Claude, Trottein, François, Faveeuw, Christelle“…The impaired cDC differentiation during IAV infection was independent of type I interferons (IFNs), IFN-γ, TNFα and IL-6 and was not due to an intrinsic dysfunction of cDC precursors. …”
Publicado 2018
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33376por Sharma, Shraddha, Wang, Jianmin, Alqassim, Emad, Portwood, Scott, Cortes Gomez, Eduardo, Maguire, Orla, Basse, Per H., Wang, Eunice S., Segal, Brahm H., Baysal, Bora E.“…While APOBEC3A edits many mRNAs in monocytes and macrophages in response to hypoxia and interferons, the physiological significance of such editing is unclear. …”
Publicado 2019
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33377por Wang, Yun, Hao, Qin, Florence, Jon M., Jung, Bock-Gie, Kurdowska, Anna K., Samten, Buka, Idell, Steven, Tang, Hua“…We identified that mediators implicated in the pathogenesis of IAV infection including interferons (IFNs), TNFα, and agonists for Toll-like receptors 3 and 4 were potent inducers of ZBP1 expression in primary murine alveolar epithelial cells, bone marrow derived macrophages, and dendritic cells. …”
Publicado 2019
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33378por Storm-Larsen, C, Myhr, K-M, Farbu, E, Midgard, R, Nyquist, K, Broch, L, Berg-Hansen, P, Buness, A, Holm, K, Ueland, T, Fallang, L-E, Burum-Auensen, E, Hov, JR, Holmøy, T“…METHODS: Thirty-six patients with relapsing–remitting multiple sclerosis received either dimethyl fumarate (n = 27) or an injectable multiple sclerosis disease-modifying therapy (glatiramer acetate or interferons, n = 9) for 12 weeks. Stool samples were collected at baseline, two and 12 weeks. …”
Publicado 2019
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33379por Bryson, Karen Jane, Garrido, Damien, Esposito, Marco, McLachlan, Gerry, Digard, Paul, Schouler, Catherine, Guabiraba, Rodrigo, Trapp, Sascha, Vervelde, Lonneke“…The PCLS were responsive to lipopolysaccharide stimulation, which induced the release of nitric oxide, IL-1β, type I interferons and IL-10. Mononuclear phagocytes within the tissue maintained phagocytic activity, with live cell imaging capturing interactions with latex beads and an avian pathogenic Escherichia coli strain. …”
Publicado 2020
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33380por Quintana, María Eugenia, Barone, Lucas José, Trotta, Myrian Vanesa, Turco, Cecilia, Mansilla, Florencia Celeste, Capozzo, Alejandra Victoria, Cardoso, Nancy Patricia“…Recently, we described the activity of type I and III interferons, IFN-α and IFN-λ respectively, against several BVDV strains in-vitro. …”
Publicado 2020
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