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33541por Uddin, Muhammad Jasim, Suen, Willy W., Bosco-Lauth, Angela, Hartwig, Airn-Elizabeth, Hall, Roy A., Bowen, Richard A., Bielefeldt-Ohmann, Helle“…PBMCs were challenged with an Australian strain of WNV (WNV(NSW2011)) and transcriptomes were quantified at 2, 6, 12 and 24 h post-infection (pi) using qRT-PCR. Type I and II interferons (IFNα, β and γ) mRNA transcription increased following WNV exposure, as did the transcripts for IL1α, IL1β, IL6, IL8, and IL22, but with slightly varying kinetics. …”
Publicado 2016
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33542“…One effective approach is to modulate the crosstalk between NK cells and dendritic cells, which produce NK cell-stimulating cytokines like type I interferons (IFN), IL-12, IL-15, and IL-18 upon retrovirus sensing or infection. …”
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33543por Wang, Xiaoqiu, Wu, Wenxin, Zhang, Wei, Leland Booth, J., Duggan, Elizabeth S., Tian, Lili, More, Sunil, Zhao, Yan D., Sawh, Ravindranauth N., Liu, Lin, Zou, Ming-Hui, Metcalf, Jordan P.“…BACKGROUND: Retinoic acid-inducible gene I (RIG-I) is an important regulator of virus-induced antiviral interferons (IFNs) and proinflammatory cytokines which participate in clearing viral infections. …”
Publicado 2017
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33544por Zhang, Pingze, Ding, Zhuang, Liu, Xinxin, Chen, Yanyu, Li, Junjiao, Tao, Zhi, Fei, Yidong, Xue, Cong, Qian, Jing, Wang, Xueli, Li, Qingmei, Stoeger, Tobias, Chen, Jianjun, Bi, Yuhai, Yin, Renfu“…Virulent NDV was found to block toll-like receptor (TLR) 7 expression, inducing higher expression of type I interferons in chicken macrophages at the late stage of viral infection. …”
Publicado 2018
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33545por Krischuns, Tim, Günl, Franziska, Henschel, Lea, Binder, Marco, Willemsen, Joschka, Schloer, Sebastian, Rescher, Ursula, Gerlt, Vanessa, Zimmer, Gert, Nordhoff, Carolin, Ludwig, Stephan, Brunotte, Linda“…Human infection with highly pathogenic avian influenza viruses (HPAIV) is often associated with severe tissue damage due to hyperinduction of interferons and proinflammatory cytokines. The reasons for this excessive cytokine expression are still incompletely understood, which has hampered the development of efficient immunomodulatory treatment options. …”
Publicado 2018
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33546por Rhead, Brooke, Brorson, Ina S., Berge, Tone, Adams, Cameron, Quach, Hong, Moen, Stine Marit, Berg-Hansen, Pål, Celius, Elisabeth Gulowsen, Sangurdekar, Dipen P., Bronson, Paola G., Lea, Rodney A., Burnard, Sean, Maltby, Vicki E., Scott, Rodney J., Lechner-Scott, Jeannette, Harbo, Hanne F., Bos, Steffan D., Barcellos, Lisa F.“…SLFN12 is a particularly compelling target of further research, as this gene is known to be down-regulated during T cell activation and up-regulated by type I interferons (IFNs), which are used to treat MS.…”
Publicado 2018
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33547por Parrini, Matthias, Meissl, Katrin, Ola, Mojoyinola Joanna, Lederer, Therese, Puga, Ana, Wienerroither, Sebastian, Kovarik, Pavel, Decker, Thomas, Müller, Mathias, Strobl, Birgit“…STAT1 has a key role in the regulation of innate and adaptive immunity by inducing transcriptional changes in response to cytokines, such as all types of interferons (IFN). STAT1 exist as two splice isoforms, which differ in regard to the C-terminal transactivation domain (TAD). …”
Publicado 2018
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33548“…BACKGROUND: Published literature suggests that early treatment with natalizumab (“escalation strategy”) is more effective than switch within the same class of immunomodulators (interferons/glatiramer acetate, “switching strategy”) in relapsing-remitting multiple sclerosis (RRMS) patients who failed first-line self-injectable disease-modifying treatment (DMT). …”
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33549por Newling, M., Fiechter, R. H., Sritharan, L., Hoepel, W., van Burgsteden, J. A., Hak, A. E., van Vollenhoven, R. F., van de Sande, M. G. H., Baeten, D. L. P., den Dunnen, J.“…One of the key factors associated with SLE pathogenesis is excessive production of type I interferons (IFNs). This could result from increased activation of type I IFN‐stimulating pathways, but also from decreased activation of type I IFN‐inhibitory pathways. …”
Publicado 2019
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33550por Zhang, Xiaoai, Xu, Hongmei, Chen, Xiaodan, Li, Xiujun, Wang, Xianjun, Ding, Shujun, Zhang, Renli, Liu, Lijuan, He, Cui, Zhuang, Lu, Li, Hao, Zhang, Panhe, Yang, Hong, Li, Tingyu, Liu, Wei, Cao, Wuchun“…Myxovirus resistance A (MxA) is an antiviral protein induced by type I interferons α and β (IFN-α and IFN-β) that can inhibit virus replication. …”
Publicado 2013
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33551por Dobrescu, I., Levast, B., Lai, K., Delgado-Ortega, M., Walker, S., Banman, S., Townsend, H., Simon, G., Zhou, Y., Gerdts, V., Meurens, F.“…Immuno-staining for both viruses and beta-tubulin, real-time quantitative PCR and ELISA assays targeting various genes (pathogen recognition receptors, interferons (IFN) type I, cytokines, and IFN-inducible genes) and proteins were performed to analyze the cell and the tissue responses. …”
Publicado 2014
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33552por Renu, Kaviyarasi, Subramaniam, Mohana Devi, Chakraborty, Rituraj, Myakala, Haritha, Iyer, Mahalaxmi, Bharathi, Geetha, Siva, Kamalakannan, Vellingiri, Balachandar, Valsala Gopalakrishnan, Abilash“…COVID-19 is causing inflammation via TNF-α and interferons. IL-4 plays an eminent role in the activation of the JAK-STAT pathway and leads to the disturbing pro-inflammatory cytokine as well as further cause’s male infertility. …”
Publicado 2020
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33553por Kumar, V.“…Upon recognition of MAMPs and DAMPs, TLRs activate downstream signaling pathways releasing several pro-inflammatory mediators [cytokines, chemokines, interferons, and reactive oxygen and nitrogen species (ROS or RNS)], which cause acute inflammation meant to control the pathogen and repair the damage. …”
Publicado 2020
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33554por Singh, Manoj Kumar, Mobeen, Ahmed, Chandra, Amit, Joshi, Sweta, Ramachandran, Srinivasan“…Genes encoding various interferons, cytokines, chemokines, and mediators of JAK-STAT pathway were positively regulated in leukemia, NAFLD, and T2D cases. …”
Publicado 2021
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33555por Wang, Shuchao, Zhang, Jingyuan, Zhang, Yanyan, Yang, Jinjin, Wang, Lidong, Qi, Yu, Han, Xun, Zhou, Xintao, Miao, Faming, Chen, Teng, Wang, Ying, Zhang, Fei, Zhang, Shoufeng, Hu, Rongliang“…Therefore, we performed experiments in domestic pigs to analyze the kinetics of representative circulating interferons (IFNs), interleukins (ILs), growth factors, tumor necrosis factors (TNFs), and chemokines induced by infection of type II virulent ASFV SY18. …”
Publicado 2021
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33556por Tang, Chih-Hang Anthony, Lee, Avery C., Chang, Shiun, Xu, Qin, Shao, Andong, Lo, Yun, Spalek, Walker T., Pinilla-Ibarz, Javier A., Del Valle, Juan R., Hu, Chih-Chi Andrew“…STING is an endoplasmic reticulum (ER)-resident protein critical for sensing cytoplasmic DNA and promoting the production of type I interferons; however, the role of STING in B cell receptor (BCR) signaling remains unclear. …”
Publicado 2020
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33557“…Data suggest that some classes of DMT, including type 1 interferons and glatiramer acetate, may not significantly impair the response to vaccination. …”
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33558por Chou, Janet, Platt, Craig D., Habiballah, Saddiq, Nguyen, Alan A., Elkins, Megan, Weeks, Sabrina, Peters, Zachary, Day-Lewis, Megan, Novak, Tanya, Armant, Myriam, Williams, Lucinda, Rockowitz, Shira, Sliz, Piotr, Williams, David A., Randolph, Adrienne G., Geha, Raif S.“…We previously reported haploinsufficiency of suppressor of cytokine signaling 1 (SOCS1), a negative regulator of type I and II interferons, as a genetic risk factor for MIS-C. OBJECTIVES: We aimed to identify additional genetic mechanisms underlying susceptibility to severe acute respiratory syndrome coronavirus 2–associated MIS-C. …”
Publicado 2021
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33559por Li, Ruizhen, Liu, Wenli, Yin, Xiangrui, Zheng, Fangfang, Wang, Zhenyu, Wu, Xingchen, Zhang, Xiaohua, Du, Qian, Huang, Yong, Tong, Dewen“…Type I interferons (IFN), a family of cytokines widely expressed in various tissues, play important roles in anti-infection immunity. …”
Publicado 2021
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33560por de Cevins, Camille, Luka, Marine, Smith, Nikaïa, Meynier, Sonia, Magérus, Aude, Carbone, Francesco, García-Paredes, Víctor, Barnabei, Laura, Batignes, Maxime, Boullé, Alexandre, Stolzenberg, Marie-Claude, Pérot, Brieuc P., Charbit, Bruno, Fali, Tinhinane, Pirabakaran, Vithura, Sorin, Boris, Riller, Quentin, Abdessalem, Ghaith, Beretta, Maxime, Grzelak, Ludivine, Goncalves, Pedro, Di Santo, James P., Mouquet, Hugo, Schwartz, Olivier, Zarhrate, Mohammed, Parisot, Mélanie, Bole-Feysot, Christine, Masson, Cécile, Cagnard, Nicolas, Corneau, Aurélien, Brunaud, Camille, Zhang, Shen-Ying, Casanova, Jean-Laurent, Bader-Meunier, Brigitte, Haroche, Julien, Melki, Isabelle, Lorrot, Mathie, Oualha, Mehdi, Moulin, Florence, Bonnet, Damien, Belhadjer, Zahra, Leruez, Marianne, Allali, Slimane, Gras-Leguen, Christèle, de Pontual, Loïc, Fischer, Alain, Duffy, Darragh, Rieux-Laucat, Fredéric, Toubiana, Julie, Ménager, Mickaël M.“…We also found a weak response to type I and type II interferons, hyperinflammation, and response to oxidative stress related to increased HIF-1α and Vascular endothelial growth factor (VEGF) signaling. …”
Publicado 2021
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