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33581por Jounai, Kenta, Ikado, Kumiko, Sugimura, Tetsu, Ano, Yasuhisa, Braun, Jonathan, Fujiwara, Daisuke“…Detailed study of Lactococcus lactis subsp. lactis JCM5805 and JCM20101 revealed that the major type I and type III interferons were induced (IFN-α, -β, and λ). IFN-α induction was TLR9 and MyD88-dependent; a slight impairment was also observed in TLR4(-/-) cells. …”
Publicado 2012
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33582por Bochkov, Yury A, Busse, William W, Brockman-Schneider, Rebecca A, Evans, Michael D, Jarjour, Nizar N, McCrae, Christopher, Miller-Larsson, Anna, Gern, James E“…CONCLUSIONS: Budesonide and formoterol can inhibit BE cell inflammatory responses in vitro without interfering with viral replication or production of interferons. These effects could potentially contribute to beneficial effects of budesonide/formoterol combination therapy in preventing RV-induced asthma exacerbations.…”
Publicado 2013
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33583por Sriram, Uma, Xu, Jun, Chain, Robert W., Varghese, Linda, Chakhtoura, Marita, Bennett, Heather L., Zoltick, Philip W., Gallucci, Stefania“…We have previously reported that IL-4, a pivotal Th2 cytokine, suppresses the response of murine bone-marrow-derived conventional dendritic cells (cDCs) and splenic DCs to Type I interferons (IFNs). Here, we analyzed cDC responses to TLR7 and TLR9 ligands, R848 and CpGs, respectively. …”
Publicado 2014
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33584por Satkunanathan, Stifani, Kumar, Naveenta, Bajorek, Monika, Purbhoo, Marco A., Culley, Fiona J.“…TLR3 and TLR2/6 ligands led to a rapid increase in LLT1 mRNA in respiratory epithelial cells, as did the proinflammatory cytokines type I interferons, interleukin 1β (IL-1β), and tumor necrosis factor alpha (TNF-α), which are produced early in respiratory-virus infection. …”
Publicado 2014
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33585por Fabre, O, Breuker, C, Amouzou, C, Salehzada, T, Kitzmann, M, Mercier, J, Bisbal, C“…It is regulated during inflammation by interferons and its activity is dependent on its binding to 2-5A, an oligoadenylate synthesized by oligoadenylate synthetases (OAS). …”
Publicado 2014
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33586por Mahmutovic-Persson, I, Akbarshahi, H, Bartlett, N W, Glanville, N, Johnston, S L, Brandelius, A, Uller, L“…CONCLUSIONS: dsRNA-induced exacerbation in mice with experimental asthma involved general inflammation, cytokines and interferons, in agreement with previous observations in exacerbating human asthma. …”
Publicado 2014
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33587“…Lactococcus lactis subsp. lactis JCM5805 (JCM5805) is a strain of lactic acid bacteria (LAB) that activates murine and human pDCs to express type I and type III interferons (IFNs). JCM5805 has also been shown to activate pDCs via a Toll-like receptor 9 (TLR9) dependent pathway. …”
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33588por Yin, Lianhong, Zheng, Lingli, Xu, Lina, Dong, Deshi, Han, Xu, Qi, Yan, Zhao, Yanyan, Xu, Youwei, Peng, Jinyong“…Many diseases including experimental autoimmune encephalomyelitis of human, temporal lobe epilepsy of rat and ankylosing spondylitis of mouse, may be inhibited by dioscin through regulating immune response alternative complement pathway, G-protein signaling RhoB regulation pathway and immune response antiviral actions of interferons, etc. The most relevant networks (5 from human, 3 from rat and 5 from mouse) indicated that dioscin may be a TOP1 inhibitor, which can treat cancer though the cell cycle– transition and termination of DNA replication pathway. …”
Publicado 2015
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33589por Mitchell, Angela M., Stone, Amy E. L., Cheng, Linling, Ballinger, Kimberly, Edwards, Michael G., Stoddard, Mark, Li, Hui, Golden-Mason, Lucy, Shaw, George M., Khetani, Salman, Rosen, Hugo R.“…Transfection with hepatitis C T/F vRNA induced robust transcriptional upregulation of type I and III interferons (IFNs) within HepG2 and TMNK-1 cells. Both the THP-1 and GEN2.2 lines demonstrated higher type I and III IFN transcription with genotype 3a compared to genotype 1a or 1b. …”
Publicado 2015
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33590por Möser, Christine V., Stephan, Heike, Altenrath, Katharina, Kynast, Katharina L., Russe, Otto Q., Olbrich, Katrin, Geisslinger, Gerd, Niederberger, Ellen“…BACKGROUND: TANK-binding kinase (TBK1) is a non-canonical IκB kinase (IKK) involved in the regulation of type I interferons and of NF-κB signal transduction. It is activated by viral infections and inflammatory mediators and has therefore been associated with viral diseases, obesity, and rheumatoid arthritis. …”
Publicado 2015
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33591por Ptaschinski, Catherine, Mukherjee, Sumanta, Moore, Martin L., Albert, Mareike, Helin, Kristian, Kunkel, Steven L., Lukacs, Nicholas W.“…Respiratory syncytial virus (RSV) infection can result in severe disease partially due to its ability to interfere with the initiation of Th1 responses targeting the production of type I interferons (IFN) and promoting a Th2 immune environment. …”
Publicado 2015
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33592por Mandl, Manuela, Drechsler, Maik, Jansen, Yvonne, Neideck, Carlos, Noels, Heidi, Faussner, Alexander, Soehnlein, Oliver, Weber, Christian, Döring, Yvonne“…BACKGROUND AND AIMS: Plasmacytoid dendritic cells (pDCs) are a small subset of dendritic cells and the main producers of type I interferons. Besides their contribution to tolerance, they are known to be involved in autoimmune diseases and have recently been implicated in atherosclerosis. …”
Publicado 2015
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33593por Elenius, Varpu, Palomares, Oscar, Waris, Matti, Turunen, Riitta, Puhakka, Tuomo, Rückert, Beate, Vuorinen, Tytti, Allander, Tobias, Vahlberg, Tero, Akdis, Mübeccel, Camargo, Carlos A., Akdis, Cezmi A., Jartti, Tuomas“…We studied how their serum levels were associated with allergy status, intratonsillar/nasopharyngeal virus detection and intratonsillar expression of T cell- and innate immune response-specific cytokines, transcription factors and type I/II/III interferons in patients undergoing tonsillectomy. METHODS: 110 elective tonsillectomy patients participated. …”
Publicado 2017
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33594por Chen, Pei-Ge, Guan, Yan-Jing, Zha, Guang-Ming, Jiao, Xian-Qin, Zhu, He-Shui, Zhang, Cheng-Yu, Wang, Yue-Ying, Li, He-Ping“…Overexpression of swine IRF3/IRF7 in PK15 cells induced type I interferons production, and attenuated inflammatory responses through TLR4 signaling pathway.…”
Publicado 2017
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33595por Zhong, Jing, Peng, Lulu, Wang, Bowen, Zhang, Henan, Li, Saiqun, Yang, Ruhui, Deng, Yuqing, Huang, Haixiang, Yuan, Jin“…PURPOSE: To investigate the expression and roles of type I and II interferons (IFNs) in fungal keratitis, as well as the therapeutic effects of tacrolimus (FK506) and voriconazole on this condition. …”
Publicado 2018
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33596por Jayakumar Sunandhakumari, Vishnu, Sadasivan, Arun, Koshi, Elizabeth, Krishna, Aswathy, Alim, Aneesh, Sebastian, Aneesh“…These cells produce the interferons (IFN) that are involved in macrophage activation, which, in turn, plays an important role in phagocytosis, complement fixation, and opsonization. …”
Publicado 2018
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33597por Smith, Julianne N. P., Zhang, Yubin, Li, Jing Jing, McCabe, Amanda, Jo, Hui Jin, Maloney, Jackson, MacNamara, Katherine C.“…Type I interferons (IFNα/β) regulate diverse aspects of host defense, but their impact on hematopoietic stem and progenitor cells (HSC/HSPCs) during infection remains unclear. …”
Publicado 2018
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33598por Hu, Qiongyuan, Ren, Huajian, Li, Guanwei, Wang, Dingyu, Zhou, Quan, Wu, Jie, Zheng, Jiashuo, Huang, Jinjian, Slade, Dominic A., Wu, Xiuwen, Ren, Jianan“…Recent research indicates the involvement of the stimulator of interferons genes (STING) pathway in uncontrolled inflammation and gut mucosal immune response. …”
Publicado 2019
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33599“…Compared to the lung samples, cells within the pleural space showed marked upregulation of many genes induced by type I interferons, which are cytokines implicated in preventing bacterial transmigration across epithelial barriers. …”
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33600“…As a first line of defense against respiratory infections, innate immune responses, including the production of type I and III interferons (IFNs), play an important role. Upon infection with RSV, multiple pattern recognition receptors (PRRs) can recognize RSV-derived pathogen-associated molecular patterns (PAMPs) and mount innate immune responses. …”
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