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33601“…BACKGROUND: During the preimplantation phase in the pig, the conceptus trophoblast elongates into a filamentous form and secretes estrogens, interleukin 1 beta 2, interferons, and other signaling molecules before attaching to the uterine epithelium. …”
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33602por Winkelmann, Alexander, Metze, Christoph, Frimmel, Silvius, Reisinger, Emil C., Zettl, Uwe K., Loebermann, Micha“…In 9 patients treated with beta interferons, GMT increased from 181 VIEU/mL to 690 VIEU/mL (p = 0.018). …”
Publicado 2019
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33603por Guo, Hongyan, Cheng, Anchun, Zhang, Xingcui, Pan, YuHong, Wang, Mingshu, Huang, Juan, Zhu, Dekang, Chen, Shun, Liu, Mafeng, Zhao, Xinxin, Wu, Ying, Yang, Qiao, Zhang, Shaqiu, Yu, Yanling, Pan, Leichang, Tian, Bin, Rehman, Mujeeb Ur, Chen, Xiaoyue, Liu, Yunya, Zhang, Ling, Yin, Zhongqiong, Jing, Bo, Jia, Renyong“…In this study, we found that the infection of ducks by DTMUV triggers Toll-like receptors (TLRs) and (RIG-I)-like receptors (RLRs) signaling pathways and inducing abundant of pro-inflammatory factors and type I interferons (IFNs), in which melanoma differentiation-associated gene 5 (MDA5) and Toll-like receptor 3 (TLR3) play important immunity roles, they can inhibit the replication process of DTMUV via inducing type I IFNs. …”
Publicado 2020
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33604por Coughlan, Lynda“…Furthermore, the excessive induction of Type I interferons by some Ad vectors has been suggested to impair transgene expression levels, dampening subsequent immune responses. …”
Publicado 2020
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33605por Molina-Carrión, Silvia, Brochado-Kith, Óscar, González-García, Juan, Berenguer, Juan, Díez, Cristina, Llop, Elba, Hontañón, Victor, Ibañez-Samaniego, Luis, Montes, Maria Luisa, Resino, Salvador, Fernández-Rodríguez, Amanda, Jiménez-Sousa, María Ángeles“…Results: In comparison with HCV-monoinfected patients, HIV/HCV-coinfected patients were younger (p < 0.001), had lower body mass index (BMI) (p = 0.002), and had been exposed less frequently to interferons (p = 0.011). In addition, they were more frequently men (p = 0.011), smokers (p = 0.005), prior intravenous drug users (IVDUs) (p < 0.001), and alcohol abusers (p = 0.005). …”
Publicado 2020
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33606por Fekete, Tünde, Ágics, Beatrix, Bencze, Dóra, Bene, Krisztián, Szántó, Antónia, Tarr, Tünde, Veréb, Zoltán, Bácsi, Attila, Pázmándi, Kitti“…Blockade of mTOR diminished the ability of RLR-stimulated moDCs and pDCs to secret type I interferons (IFNs) and pro-inflammatory cytokines, while it did not affect the phenotype of DCs. …”
Publicado 2020
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33607por Balla, Mamtha, Merugu, Ganesh Prasad, Konala, Venu Madhav, Sangani, Vikram, Kondakindi, Hema, Pokal, Mytri, Gayam, Vijay, Adapa, Sreedhar, Naramala, Srikanth, Malayala, Srikrishna V“…ABBREVIATIONS: Vitamin D receptor-VDR; 25(OH)D- 25 hydroxyvitamin D; 1,25 (OH)D-1,25 dihydroxy Vitamin D; 1α,25-dihydroxy Vitamin D-1,25[OH](2) D or calcitriol; IU- International Units; Interferons stimulated genes- ISG; ARI- acute respiratory infection; RSV- respiratory syncytial virus; RTI- Respiratory tract infections; COPD-Chronic obstructive pulmonary disease; BMI-Basal metabolic index; USA-USA.…”
Publicado 2020
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33608“…ILDs are correlated with the occurrence of pulmonary fibrosis (PF), which generally also results in pulmonary hypertension (PH). Interferons, secreted in larger amounts during viral infections, are an important possible risk factor contributing to this outcome. …”
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33609“…TLR4 is an innate immune receptor on the cell surface that recognizes pathogen-associated molecular patterns (PAMPs) including viral proteins and triggers the production of type I interferons and proinflammatory cytokines to combat infection. …”
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33610por Bonser, Luke R., Eckalbar, Walter L., Rodriguez, Lauren, Shen, Jiangshan, Koh, Kyung Duk, Zlock, Lorna T., Christenson, Stephanie, Woodruff, Prescott G., Finkbeiner, Walter E., Erle, David J.“…CONCLUSIONS: IL-13 markedly reduces susceptibility of HBECs to SARS-CoV-2 infection through mechanisms that likely differ from those activated by type I interferons. Our findings may help explain reports of relatively low prevalence of asthma in patients diagnosed with COVID-19 and could lead to new strategies for reducing SARS-CoV-2 infection.…”
Publicado 2021
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33611por Sehgal, Pravin B., Yuan, Huijuan, Scott, Mia F., Deng, Yan, Liang, Feng-Xia, Mackiewicz, Andrzej“…Type I and III interferons induce expression of the “myxovirus resistance proteins” MxA in human cells and its ortholog Mx1 in murine cells. …”
Publicado 2021
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33612por Takatani, Ayuko, Nakamura, Hideki, Furukawa, Kaori, Endo, Yushiro, Umeda, Masataka, Shimizu, Toshimasa, Nishihata, Shin‐ya, Kitaoka, Kyoko, Nakamura, Tatsufumi, Kawakami, Atsushi“…After direct coculture with the HTLV‐1‐infected T‐cell line HCT‐5 or MT‐2, the BAFF and CXCL13 expressions on the FDC‐like cells were decreased in accord with the increased number of HCT‐5 and MT‐2 cells with styliform change and without HTLV‐1 Gag protein expression. Interferons upregulated the concentration of BAFF (but not CXCL13) in the culture supernatant, which showed a declining trend under the presence of HCT‐5 or MT‐2. …”
Publicado 2021
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33613por Minaga, Kosuke, Watanabe, Tomohiro, Hara, Akane, Yoshikawa, Tomoe, Kamata, Ken, Kudo, Masatoshi“…Although plasmacytoid dendritic cells (pDCs) able to produce large amounts of type 1 interferons (IFN-I) play beneficial roles in host defense against viral infections, excessive activation of pDCs, followed by robust production of IFN-I, causes autoimmune disorders including systemic lupus erythematosus (SLE) and psoriasis. …”
Publicado 2021
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33614por Iuliano, Marco, Mangino, Giorgio, Chiantore, Maria Vincenza, Di Bonito, Paola, Rosa, Paolo, Affabris, Elisabetta, Romeo, Giovanna“…They counteract the cellular antiviral defense through viral proteins as well as specific cellular effectors involved in virus-induced tumorigenesis. Type I interferons (IFNs) are a family of cytokines critical not only for viral interference but also for their broad range of properties that go beyond the antiviral action. …”
Publicado 2021
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33615por Bonato, Matteo, Gallo, Elisa, Turrin, Martina, Bazzan, Erica, Baraldi, Federico, Saetta, Marina, Gregori, Dario, Papi, Alberto, Contoli, Marco, Baraldo, Simonetta“…We previously reported impaired Type-I and Type-III interferons (IFN-β/λ) from airway epithelial cells of preschool children with asthma and/or atopy. …”
Publicado 2021
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33616por Zhang, Wei, Tan, Beiping, Deng, Junming, Yang, Qihui, Chi, Shuyan, Pang, Aobo, Xin, Yu, Liu, Yu, Zhang, Haitao“…These culminated in the transcriptome activation of NF-κB, IRFs, and costimulatory molecules, ultimately promoting the expressions of proinflammatory cytokines, interferons (IFNs), chemokines, and other molecules vital to the innate and/or adaptive immune responses. …”
Publicado 2022
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33617“…The study was motivated particularly by a need to establish the safety profile of newer DMTs, but will also gather data on outcomes among treatment-eligible but untreated patients and those receiving established DMTs (interferons and glatiramer acetate). It will also explore the impact of treatment switching. …”
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33618“…At 28 d of age, the offspring following maternal stevioside supplementation exhibited higher jejunal secretory immunoglobulin A and serum interferons levels (P < 0.05). A higher abundance of Lactobacillales induced by maternal stevioside supplementation was positively correlated with intestinal immune-related factors (P < 0.05). …”
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33619por Schmitz, Yasmin, Schwerdtfeger, Mara, Westmeier, Jaana, Littwitz-Salomon, Elisabeth, Alt, Mira, Brochhagen, Leonie, Krawczyk, Adalbert, Sutter, Kathrin“…Type I interferons (IFNs) present the first line of defense against viral infections, providing antiviral, immunomodulatory and antiproliferative effects. …”
Publicado 2022
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33620por Yang, Xiaodan, Liu, Xiaosong, Li, Junjie, Zhang, Pingping, Li, Hejie, Chen, Guoqiang, Zhang, Wei, Wang, Tianfang, Frazer, Ian, Ni, Guoying“…The modulated macrophages by caerin 1.1/1.9 show significant activation of Type I interferons response and Stat1 signalling, rendering animals resistant to further tumour challenges. …”
Publicado 2022
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