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  1. 33621
    “…The oligoadenylate synthesis (OAS) gene family, which is an important component of the immune system, provides an essential response to the antiviral activities of interferons by regulating immune signal pathways. However, little is known about the evolutionary characteristics of OASs in Laurasiatherian mammals. …”
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    Adaptive Evolution of the OAS Gene Family Provides New Insights into the Antiviral Ability of Laurasiatherian Mammals
  2. 33622
    “…Conclusions: This study suggests that tears create an acute proinflammatory milieu driving the PED disease pathology, whereas the PED patients scrapes are an indicator of the chronic stage of the disease. Interferons, pro-inflammatory genes, and their pathways are involved in PED, which can be a potential target for inducing epithelialization of the cornea.…”
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    Prolonged Inflammation and Infectious Changes in the Corneal Epithelium Are Associated with Persistent Epithelial Defect (PED)
  3. 33623
    “…They include chemokines, interleukins (ILs), adipokines, interferons, colony-stimulating factors (CSFs), and tumor necrosis factor (TNF), which are produced by a wide range of cells, including immune cells, such as macrophages, B-cells, T-cells, and mast cells, as well as endothelial cells, fibroblasts, a variety of stromal cells, and some cancer cells. …”
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    Crosstalk of Inflammatory Cytokines within the Breast Tumor Microenvironment
  4. 33624
    “…Finally, we identified several negative regulators of asthmatic CD4 T cell responses to allergens (e.g. IL-10, type I interferons, microRNAs, drugs, metabolites), and these represent logical candidates for therapeutic intervention. …”
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    Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses
  5. 33625
    “…VIB9600 inhibits IC-induced type I interferons from plasmacytoid dendritic cells (involved in SLE), antineutrophil cytoplasmic antibody (ANCA)-induced production of reactive oxygen species by neutrophils (involved in ANCA-associated vasculitis) and IC-induced tumour necrosis factor α and interleukin-6 production (involved in rheumatoid arthritis). …”
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    Humanised effector-null FcγRIIA antibody inhibits immune complex-mediated proinflammatory responses
  6. 33626
    por Moyo, Mack, Van Staden, Johannes
    Publicado 2014
    “…RESULTS: Experimental results from in vitro studies indicate that bioactive phytochemical constituents of Pelargonium sidoides may not possess a direct antimicrobial effect, but instead act by interfering with microbial binding to host cell receptors, inhibition of key enzymes and the production of antimicrobial effector molecules such as nitric oxide and interferons (IFNs) by the host cells. Furthermore, clinical evaluations in randomised, double-blind, placebo-controlled trials have demonstrated the beneficial effect of Pelargonium sidoides in the treatment of respiratory tract infections with few side effects. …”
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    Medicinal properties and conservation of Pelargonium sidoides DC.
  7. 33627
    “…RESULTS: : Several studies demonstrated preserved immune responses in people treated with beta-interferons to multiple vaccine types. Limited data suggest vaccine responses to be preserved with dimethyl fumarate treatment, as well. …”
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    Effects of MS disease-modifying therapies on responses to vaccinations: A review.
  8. 33628
    “…ESC group patients received the high efficacy DMT after ⩾1 year of glatiramer acetate, interferons, azathioprine, teriflunomide or dimethylfumarate treatment. …”
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    Long-term disability trajectories in relapsing multiple sclerosis patients treated with early intensive or escalation treatment strategies
  9. 33629
    por Albutti, Aqel
    Publicado 2021
    “…The vaccine also simulates profound primary, secondary, tertiary immunoglobulin production as well as high interleukins and interferons count. In summary, the designed vaccine is ideal to be evaluated experimentally to decipher its real biological efficacy in controlling drug resistant infections of M. tuberculosis.…”
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    An integrated computational framework to design a multi-epitopes vaccine against Mycobacterium tuberculosis
  10. 33630
    “…The absence of secretion of immune cytokines such as interferons, which play an important role in controlling viral infection in the early stages, is a complication of this event. …”
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    The role of HLA genotypes in understanding the pathogenesis of severe COVID-19
  11. 33631
    “…One of the major pathogenesis mechanisms of SARS-CoV-2 is its potent suppression of innate immunity, including blocking the production of type I interferons. However, it is unknown whether and how the virus interacts with different innate-like T cells, including NKT, MAIT and γδ T cells. …”
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    Potent NKT cell ligands overcome SARS-CoV-2 immune evasion to mitigate viral pathogenesis in mouse models
  12. 33632
    “…This killing could be enhanced by addition of other cytokines including interferons alpha, beta and gamma. Study of a panel of 15 tumour cell lines using a single effector showed that there was no statistically significant inverse correlation (using Spearman rank test) between the degree of tumour class I expression and LAK/NK killing at 20/1 (r = 0.23 P = 0.39) and 10/1 (r = 0.30, P = 0.27) and at 5/1 E/T ratio r = 0.47, P = 0.08) respectively. …”
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    Intensity of class I antigen expression on human tumour cell lines and its relevance to the efficiency of non-MHC-restricted killing.
  13. 33633
    “…BACKGROUND: Interferons are a group of proteins that trigger multiple responses including prevention of viral replication, inhibition of cell growth, and modulation of cell differentiation. …”
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    Influence of IFN-gamma and its receptors in human breast cancer
  14. 33634
    “…Although several conventional therapies are currently available, they have a low efficacy and the more effective treatment modalities need to be established. Interferons (IFNs) are one of such options known as immunotherapy and demonstrated their antitumor effects on certain cancer types. …”
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    Possible immunotherapeutic potentiation with D-Fraction in prostate cancer cells
  15. 33635
    “…Chemotherapeutic agents including interferons, cytokines, biological agents and radiation therapy for brain metastases have been reported as adjuvant and palliative options while considering malignant melanomas in general. …”
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    Pathogenesis, diagnosis and management of primary melanoma of the colon
  16. 33636
    “…RESULTS: JS5/05 and JS3/05 caused hyperinduction of type I interferons (IFNs) (IFN-α and -β) during detection period compared to F48E8 and Herts/33. …”
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    Strong innate immune response and cell death in chicken splenocytes infected with genotype VIId Newcastle disease virus
  17. 33637
    “…Studies have demonstrated over-activated signaling of myelo-suppressive cytokines such as TGF-β, TNF-α and Interferons in MDS hematopoietic stem cells. Targeting these signaling cascades could be potentially therapeutic in MDS. …”
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    Signal transduction inhibitors in treatment of myelodysplastic syndromes
  18. 33638
    “…Upstream regulator analyses also predicted TNF, interferons γ and β1 and interleukin 1β. CONCLUSIONS: In vitro, the transcriptome of granulosa cells responded minimally to FSH compared with the response to TNFα. …”
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    The global effect of follicle-stimulating hormone and tumour necrosis factor α on gene expression in cultured bovine ovarian granulosa cells
  19. 33639
    “…However, our immunoprofiling of macrophage over expression also shows that AH is driven by receptors, interferons, and cytokines that are commonly associated not just with M2 macrophages, but with M1 as well. …”
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    The liver is populated by a broad spectrum of markers for macrophages. In alcoholic hepatitis the macrophages are M1 and M2(☆)
  20. 33640
    “…Half of the sample was using glatiramer acetate and half was using beta-interferons. CONCLUSION: Demographic and clinical characteristics of the TOP MS sample at enrollment are consistent with other community-based MS samples, and the sample appears to be representative of DMT users in the US. …”
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    Therapy optimization in multiple sclerosis: a prospective observational study of therapy compliance and outcomes
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