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33641“…BACKGROUND: Interferons (IFN) are cytokines secreted by vertebrate cells involved in activation of signaling pathways that direct the synthesis of antiviral genes. …”
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33642“…The modified Rio score, currently validated for the evaluation of treatment response to interferons, will be used to evaluate the treatment response to fingolimod. …”
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33643por Flisiak, Robert, Shiffman, Mitchell, Arenas, Juan, Cheinquer, Hugo, Nikitin, Igor, Dong, Yuping, Rana, Khurram, Srinivasan, Subasree“…As expected based on the safety profile of the 2 interferons, there were more hepatobiliary events observed in the Lambda arm and more hematologic events in the Alfa arm. …”
Publicado 2016
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33644por Studzińska, Mirosława, Jabłońska, Agnieszka, Wiśniewska-Ligier, Małgorzata, Nowakowska, Dorota, Gaj, Zuzanna, Leśnikowski, Zbigniew J., Woźniakowska-Gęsicka, Teresa, Wilczyński, Jan, Paradowska, Edyta“…Intracellular Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA (dsRNA) and activates antiviral immune responses through the production of type I interferons (IFNs) and inflammatory cytokines. This receptor binds to dsRNA molecules produced during human cytomegalovirus (HCMV) replication. …”
Publicado 2017
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33645por Takahashi, Hideki, Misato, Kazuki, Aoshi, Taiki, Yamamoto, Yasuyuki, Kubota, Yui, Wu, Xin, Kuroda, Etsushi, Ishii, Ken J., Yamamoto, Hirofumi, Yoshioka, Yasuo“…However, the development of novel delivery vehicles that enhance the adjuvant effects of CpG ODNs, subsequently increasing the production of cytokines such as type-I interferons (IFNs), is highly desirable. In this study, we demonstrate the potential of pH-responsive biodegradable carbonate apatite (CA) nanoparticles as CpG ODN delivery vehicles that can enhance the production of type-I IFNs (such as IFN-α) relative to that induced by CpG ODNs and can augment the adjuvant effects of CpG ODNs in vivo. …”
Publicado 2018
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33646por Weinberger, Birgit, Haks, Mariëlle C., de Paus, Roelof A., Ottenhoff, Tom H. M., Bauer, Tanja, Grubeck-Loebenstein, Beatrix“…Focused gene expression profiling identified 29 transcripts that correlated with age at baseline and clustered in a network centered around type I interferons and pro-inflammatory cytokines. In addition, smaller 8- and 6-gene signatures were identified at baseline that associated with vaccine responsiveness during primary and booster vaccination, respectively. …”
Publicado 2018
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33647por Dayer, Jean-Michel“…Long-term cell cultures developed early in the twentieth century allowed identification in their supernatants of biological mediators subsequently defined as migration factors, interferons, lymphokines, monokines, cytokines and interleukins. …”
Publicado 2018
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33648por Hussain, Rehana Z., Cravens, Petra C., Doelger, Richard, Dentel, Brianne, Herndon, Emily, Loof, Nicolas, Tsai, Peter, Okuda, Darin T., Racke, Michael K., Stüve, Olaf“…The initial host response to viral infections entails the synthesis of type I interferons (IFN) upon engagement of TLR3 receptors. …”
Publicado 2018
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33649por Cheng, Yuqiang, Lun, Minxiang, Liu, Yunxia, Wang, Hengan, Yan, Yaxian, Sun, Jianhe“…TANK-binding kinase 1 (TBK1) is involved in innate immunity, prompting transcriptional induction of type I interferons in response to pathogenic infection. Many studies have focused on mammals but the function of TBK1 in chickens remains poorly defined. …”
Publicado 2019
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33650por Hayashida, Emina, Ling, Zheng Lung, Ashhurst, Thomas M., Viengkhou, Barney, Jung, So Ri, Songkhunawej, Pattama, West, Phillip K., King, Nicholas J. C., Hofer, Markus J.“…To determine the contribution of type I interferons (IFN-Is) and adaptive immune cells, we also studied mice deficient for the IFN-I receptor 1 (Ifnar1(−/−)) and recombination-activating gene 1 (Rag1(−/−)). …”
Publicado 2019
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33651por Wu, Siyu, Huang, Jianni, Huang, Qiwen, Zhang, Junsheng, Liu, Jing, Xue, Qian, Li, Weiqiang, Liao, Ming, Jiao, Peirong“…Furthermore, we found that mRNA of pattern recognition receptors (PRRs), interferons (IFNs), and stimulated genes (ISGs) exhibited different levels of activation in the lungs and spleens of the two H5N6 viruses-inoculated geese though did not protect these birds from H5N6 HPAIVs infection. …”
Publicado 2020
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33652The 2–5 A system: Modulation of viral and cellular processes through acceleration of RNA degradation“…The 2–5A system is an RNA degradation pathway that can be induced by the interferons (IFNs). Treatment of cells with IFN activates genes encoding several double-stranded RNA (dsRNA)-dependent synthetases. …”
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33653por Waddington, Kirsty E., Papadaki, Artemis, Coelewij, Leda, Adriani, Marsilio, Nytrova, Petra, Kubala Havrdova, Eva, Fogdell-Hahn, Anna, Farrell, Rachel, Dönnes, Pierre, Pineda-Torra, Inés, Jury, Elizabeth C.“…Up to 35% of MS patients treated with beta interferons (IFNβ) develop ADA. Here we use machine learning to predict immunogenicity against IFNβ utilizing serum metabolomics data. …”
Publicado 2020
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33654por Shah, Vibhuti Kumar, Firmal, Priyanka, Alam, Aftab, Ganguly, Dipyaman, Chattopadhyay, Samit“…Due to the limitations of plasma transfusion, researchers are now focusing on developing neutralizing antibodies against virus particles along with immuno-modulation of cytokines like IL-6, Type I interferons (IFNs), and TNF-α that could help in combating the infection. …”
Publicado 2020
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33655por Ramu, Sangeetha, Calvén, Jenny, Michaeloudes, Charalambos, Menzel, Mandy, Akbarshahi, Hamid, Chung, Kian Fan, Uller, Lena“…Recently we showed that RV infects bronchial smooth muscle cells (BSMCs) triggering production of interferons and IL-33. Here we compared levels of RV-induced IL-33 in BSMCs from healthy and asthmatic subjects, and explored the involvement of pattern-recognition receptors (PRRs) and downstream signalling pathways in IL-33 expression. …”
Publicado 2020
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33656por Troya, Jesús, Bastard, Paul, Planas-Serra, Laura, Ryan, Pablo, Ruiz, Montse, de Carranza, María, Torres, Juan, Martínez, Amalia, Abel, Laurent, Casanova, Jean-Laurent, Pujol, Aurora“…BACKGROUND: In a recent study, autoantibodies neutralizing type I interferons (IFNs) were present in at least 10% of cases of critical COVID-19 pneumonia. …”
Publicado 2021
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33657por Zhang, Keshan, Yan, Minghao, Hao, Junhong, Shen, Chaochao, Zhu, Zixiang, Zhang, Dajun, Hou, Jing, Xu, Guowei, Li, Dan, Zheng, Haixue, Liu, Xiangtao“…This study was the first to demonstrate the antiviral effect of host TPL2 during FMDV replication by increasing production of interferons and antiviral cytokines. Both FMDV and VP1 protein can reduce host TPL2, ABIN2, and p105 to destroy the TPL2-p105-ABIN2 trimer complex. …”
Publicado 2021
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33658por Xue, Yuan Chao, Ng, Chen Seng, Mohamud, Yasir, Fung, Gabriel, Liu, Huitao, Bahreyni, Amirhossein, Zhang, Jingchun, Luo, Honglin“…We show that in the absence of FUS, gene expression of type I interferons and proinflammatory cytokines elicited by viral or bacterial infection is significantly impaired. …”
Publicado 2021
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33659“…Plasmacytoid dendritic cells (pDCs) are the key producers of type I interferons (IFNs), thus playing a central role in initiating antiviral immune response. …”
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33660por Chakraborty, Chiranjib, Sharma, Ashish Ranjan, Bhattacharya, Manojit, Agoramoorthy, Govindasamy, Lee, Sang-Soo“…The paper also outlines the experiences gained during the repurposing of therapeutic molecules (hydroxychloroquine, ritonavir/ lopinavir, favipiravir, remdesivir, ivermectin, dexamethasone, camostatmesylate, and heparin), immunotherapeutic molecules (tocilizumab, mavrilimumab, baricitinib, and interferons), combination therapy, and convalescent plasma therapy to treat COVID-19 patients. …”
Publicado 2021
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