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33661por Peng, Yuan, Chen, Yonghong, Song, Mengmeng, Zhang, Xiaoyue, Li, Pansong, Yu, Xian, Huang, Yusheng, Zhang, Ni, Ji, Liyan, Xia, Lei, Xia, Xuefeng, Yi, Xin, Tan, Benxu, Yang, Zhenzhou“…In contrast, homozygous deletion of type I interferons (IFN‐I(HD)) frequently co‐occurred with CDKN2A/B(HD). …”
Publicado 2022
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33662“…Once activated, JAKs act on pathways for either survival, proliferation, differentiation, immune regulation or, in the case of type I interferons, antiviral and antiproliferative effects. …”
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33663por Mushtaq, Saima, Hashmi, Asraf Hussain, Khan, Amjad, Asad Raza Kazmi, Syed Muhammad, Manzoor, Sobia“…RASs were detected at the baseline in 15/76 patients and at relapse in 20/76 patients with cirrhosis and previously treated with interferons. The most prevalent NS5A RAS was Y93H found in all treatment-failing patients (14/54 in DCV vs. 6/22 in VEL), followed by A62S/T and A30K. …”
Publicado 2022
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33664“…CONCLUSIONS: Targeting GSDMD could promote expression of interferons through inactivation of cGAS pathway and downregulated the PD-L1 expression. …”
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33665“…Patients received SARS-CoV-2 mRNA vaccine as part of their clinical routine during ongoing siponimod treatment (cohort 1), during siponimod treatment interruption (cohort 2), or while on dimethyl fumarate, glatiramer acetate, beta-interferons, teriflunomide, or no current therapy (cohort 3). …”
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33666A Comprehensive Review on the Efficacy of Several Pharmacologic Agents for the Treatment of COVID-19“…Lopinavir/ ritonavir, favipiravir, ivermectin, nirmatrelvir, interferons, corticosteroids, tocilizumab, sarilumab, siltuximab, canakinumab, colchicine, tofacitinib, thalidomide, convalescent plasma therapy, and mesenchymal stem cells have been shown to have positive effects to treat COVID-19 patients, while anakinra, ruxolitinib, and azithromycin have proven ineffective for COVID-19 therapy; however, no solid conclusion has been obtained from the results of different clinical trials. …”
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33667por Sertznig, Helene, Roesmann, Fabian, Wilhelm, Alexander, Heininger, Delia, Bleekmann, Barbara, Elsner, Carina, Santiago, Mario, Schuhenn, Jonas, Karakoese, Zehra, Benatzy, Yvonne, Snodgrass, Ryan, Esser, Stefan, Sutter, Kathrin, Dittmer, Ulf, Widera, Marek“…Efficient HIV-1 replication depends on balanced levels of host cell components including cellular splicing factors as the family of serine/arginine-rich splicing factors (SRSF, 1–10). Type I interferons (IFN-I) play a crucial role in the innate immunity against HIV-1 by inducing the expression of IFN-stimulated genes (ISGs) including potent host restriction factors. …”
Publicado 2022
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33668por Reid, Cian, Flores-Villalva, Susana, Remot, Aude, Kennedy, Emer, O’Farrelly, Cliona, Meade, Kieran G.“…Transcriptomic analysis in unstimulated whole blood cells revealed increased expression of type I interferons and chemokines in vitamin D supplemented calves, while IL-1 and inflammasome gene expression was decreased. …”
Publicado 2023
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33669“…Additionally, the ADAR1 p150 isoform is induced by interferons in viral infection and plays a role in antiviral immune response. …”
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33670por Beyzarov, Elena, Chen, Yan, Julg, Rob, Naim, Karen, Shah, Jigna, Gregory, William W., Ayoub, Ayman, Caubel, Patrick“…In cases involving off-label pharmacotherapy use for the treatment of COVID-19-related conditions, the most frequently reported therapeutic classes included antibiotics, antimalarial agents, antivirals/antiretroviral agents, immunosuppressant/immunomodulating agents, corticosteroids, anticoagulants, and immunoglobulin/interferons. The most frequently reported pharmacotherapeutic agents were azithromycin and chloroquine/hydroxychloroquine, followed by lopinavir-ritonavir, ceftriaxone, and tofacitinib. …”
Publicado 2020
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33671por Maruyama, Sandra Regina, Fuzo, Carlos Alessandro, Oliveira, Antonio Edson R., Rogerio, Luana Aparecida, Takamiya, Nayore Tamie, Pessenda, Gabriela, de Melo, Enaldo Vieira, da Silva, Angela Maria, Jesus, Amélia Ribeiro, Carregaro, Vanessa, Nakaya, Helder I., Almeida, Roque Pacheco, da Silva, João Santana“…Overall, pathway analysis corroborated the importance of signaling involving interferons, chemokines, Toll-like receptors and the neutrophil response. …”
Publicado 2022
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33672“…LPS/ATP treatment resulted in activation of NLRP3 inflammasome and secretion of IL-1β as well as interferons (IFNs) and monocyte chemotactic protein-1 (MCP-1) in the Raw 264.7 macrophages. …”
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33673por Arrestier, Romain, Bastard, Paul, Belmondo, Thibaut, Voiriot, Guillaume, Urbina, Tomas, Luyt, Charles-Edouard, Gervais, Adrian, Bizien, Lucy, Segaux, Lauriane, Ben Ahmed, Mariem, Bellaïche, Raphaël, Pham, Taï, Ait-Hamou, Zakaria, Roux, Damien, Clere-Jehl, Raphael, Azoulay, Elie, Gaudry, Stéphane, Mayaux, Julien, Fage, Nicolas, Ait-Oufella, Hafid, Moncomble, Elsa, Parfait, Mélodie, Dorgham, Karim, Gorochov, Guy, Mekontso-Dessap, Armand, Canoui-Poitrine, Florence, Casanova, Jean-Laurent, Hue, Sophie, de Prost, Nicolas“…BACKGROUND: Auto-antibodies (auto-Abs) neutralizing type I interferons (IFN) have been found in about 15% of critical cases COVID-19 pneumonia and less than 1% of mild or asymptomatic cases. …”
Publicado 2022
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33674por Gillespie, Iain A., Chan, K. Arnold, Liu, Yunhao, Hsieh, Shu-Feng, Schindler, Christian, Cheng, Wendy, Chang, Rose, Kap, Elisabeth, Morais, Eleonora, Duh, Mei Sheng, Park, Suna, Ketz, Miriam, Jenner, Sarah, Boxall, Naomi, Kendrick, Stuart, Theodore, Dickens“…In total, 19.2%, 11.1%, and 5.9% of non-coinfected adult patients received treatment at index in the US, Germany, and Taiwan, respectively; most frequently with nucleos(t)ide analogue monotherapy (94.4%, 97.2%, 99.8% of treated patients, respectively) and rarely with interferons (0.27%, 1.63%, and 0.06%, respectively). …”
Publicado 2022
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33675por Liu, Shougang, Liu, Fanghua, Zhang, Zeqiao, Zhuang, Zhe, Yuan, Xiuqing, Chen, Yongfeng“…Immune response analysis showed that TNF family members, chemokine receptors, interferons, natural killer cells, and TGF-β family members might be involved in psoriasis. …”
Publicado 2023
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33676por Di Fusco, Davide, Segreto, Maria Teresa, Iannucci, Andrea, Maresca, Claudia, Franzè, Eleonora, Di Maggio, Giulia, Di Grazia, Antonio, Boccanera, Siro, Laudisi, Federica, Marafini, Irene, Paoluzi, Omero Alessandro, Michienzi, Alessandro, Monteleone, Giovanni, Monteleone, Ivan“…BACKGROUND AND AIM: Type I interferons (IFNs) are highly expressed in the gut mucosa of celiac disease (CD) gut mucosa and stimulates immune response prompted by gluten ingestion, but the processes that maintain the production of these inflammatory molecules are not well understood. …”
Publicado 2023
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33677por Fang, Ying, Zhang, Mu-Chen, He, Yang, Li, Chen, Fang, Hai, Xu, Peng-Peng, Cheng, Shu, Zhao, Yan, Feng, Yan, Liu, Qian, Wang, Li, Zhao, Wei-Li“…In TP53(mut) DLBCL cell lines, decitabine down-regulated SUV39H1, inhibited H3K9me3 occupancy on ERVs, and triggered ERV expression, thereby unleashing interferons program and CD4(+)T/CD8(+)T cell activation. …”
Publicado 2023
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33678“…Four groups of biologics were found to improve outcomes. Anti-interferons: Anifrolumab increased BICLA response and SRI 5 to 8, decreased prednisone dosages, with increased herpes zoster infections, but fewer serious adverse events. …”
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33679por Gandhi, Shipra, Opyrchal, Mateusz, Grimm, Melissa J, Slomba, Ronald T, Kokolus, Kathleen M, Witkiewicz, Agnieszka, Attwood, Kristopher, Groman, Adrienne, Williams, Lauren, Tarquini, Mary Lynne, Wallace, Paul K, Soh, Kah Teong, Minderman, Hans, Maguire, Orla, O’Connor, Tracey L, Early, Amy P, Levine, Ellis G, Kalinski, Pawel“…The ability of toll-like receptor 3 (TLR3) ligands, interferons (IFNs) and COX2 inhibitors to synergistically induce CTL-attracting chemokines (but not regulatory T cell (Treg)-attractants) in the TME, but not in healthy tissues, observed in our preclinical studies, suggested that their systemic application can reprogram local TMEs. …”
Publicado 2023
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33680por Lee, Andrew C. Y., Zhang, Anna J. X., Chu, Hin, Li, Can, Zhu, Houshun, Mak, Winger W. N., Chen, Yanxia, Kok, Kin-Hang, To, Kelvin K. W., Yuen, Kwok-Yung“…Specifically, caspase inhibition significantly enhanced, while RIPK3 inhibition reduced the early expression of type I interferons and cytokine/chemokines in H7N9-infected monocytes. …”
Publicado 2019
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