-
33701por Lu, Zhongyan, Pena-DaMata, Jarina, Pohida, Katherine, Lake, Camille, Epsi, Nusrat J, Richard, Stephanie A, Agan, Brian, Pollett, Simon, Simons, Mark P, Dalgard, Clifton, Blair, Paul W, Chenoweth, Josh, Snow, Andrew L, Burgess, Timothy, Malloy, Allison M“…Dysregulation of innate immune factors that facilitate viral clearance and the adaptive response, such as type I interferons, have been implicated in severe COVID-19. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33702por Endres, Adrian, Hügel, Christian, Boland, Helena, Hogardt, Michael, Schubert, Ralf, Jonigk, Danny, Braubach, Peter, Rohde, Gernot, Bellinghausen, Carla“…Virus infection stimulated the production of inflammatory and antiviral mediators, including interleukin (IL)-6, CXCL-8, tumor necrosis factor (TNF)-α, and type I/III interferons. Co-infection with a non-mucoid PA isolate increased IL-1β protein concentrations (28.88 pg/ml vs. 6.10 pg/ml), but in contrast drastically diminished levels of IL-6 protein (53.17 pg/ml vs. 2301.33 pg/ml) compared to virus infection alone. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33703por Fitzpatrick, John-Mark, Hackett, Becky, Costelloe, Lisa, Hind, William, Downer, Eric J.“…The innate immune response to bacterial and viral molecules involves the coordinated production of cytokines, chemokines, and type I interferons (IFNs), which is orchestrated by toll-like receptors (TLRs). …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33704por Dubuc, Isabelle, Prunier, Julien, Lacasse, Émile, Gravel, Annie, Puhm, Florian, Allaeys, Isabelle, Archambault, Anne-Sophie, Gudimard, Leslie, Villano, Rosaria, Droit, Arnaud, Flamand, Nicolas, Boilard, Éric, Flamand, Louis“…RNA-Seq analysis of lung tissues indicate that SARS-CoV-2 infection results in the progressive modulation of several hundred genes, including several inflammatory mediators and genes related to the interferons. Analysis of the lung lipidome indicated modest, yet significant modulation of a minority of lipids. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33705por Kelly, Jenna N., Laloli, Laura, V’kovski, Philip, Holwerda, Melle, Portmann, Jasmine, Thiel, Volker, Dijkman, Ronald“…Multiple infected cell types were shown to upregulate interferons (IFN), with type III IFNs clearly dominating the antiviral response. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33706por Wang, Lin, Yang, Zhihua, Yu, Hangxing, Lin, Wei, Wu, Ruoxi, Yang, Hongtao, Yang, Kang“…Both of which covered macrophages and interferons. The disease enrichment analysis of DEGs in kidney tissues showed that they were mainly involved in immune and renal diseases, and in peripheral blood it was mainly enriched in cardiovascular system, bone marrow, and oral cavity. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33707por Netea, Stejara A., Biesbroek, Giske, van Stijn, Diana, Ijspeert, Hanna, van der Made, Caspar I., Jansen, Machiel H., Geissler, Judy, van den Berg, J.M. (Merlijn), van der Kuip, Martijn, Gruppen, Mariken P., Schonenberg-Meinema, Dieneke, Kapitein, Berber, van Furth, A.M. (Marceline) Tutu, Nagelkerke, Sietse Q., Pajkrt, Dasja, Plötz, Frans B., den Boer, M.E.J. (Lisette), Landman, Gijs W., van Houten, Marlies A., Goetschalckx, Ines, Toonen, Erik J.M., van de Veerdonk, Frank L., Kuipers, Irene M., Dik, Willem A., Kuijpers, Taco W.“…Disease severity in adult COVID-19 is associated to the presence of anti-cytokine autoantibodies (ACAAs) against type I interferons. Similarly, ACAAs may be implicated in KD and MIS-C. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33708por Janovec, Vaclav, Aouar, Besma, Font-Haro, Albert, Hofman, Tomas, Trejbalova, Katerina, Weber, Jan, Chaperot, Laurence, Plumas, Joel, Olive, Daniel, Dubreuil, Patrice, Nunès, Jacques A., Stranska, Ruzena, Hirsch, Ivan“…Recent studies have reported that the crosslinking of regulatory receptors (RRs), such as blood dendritic cell antigen 2 (BDCA-2) (CD303) or ILT7 (CD85g), of plasmacytoid dendritic cells (pDCs) efficiently suppresses the production of type I interferons (IFN-I, α/β/ω) and other cytokines in response to toll-like receptor 7 and 9 (TLR7/9) ligands. …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33709por Ramu, Sangeetha, Akbarshahi, Hamid, Mogren, Sofia, Berlin, Frida, Cerps, Samuel, Menzel, Mandy, Hvidtfeldt, Morten, Porsbjerg, Celeste, Uller, Lena, Andersson, Cecilia K.“…Furthermore, tryptase significantly reduced type-I and III interferons (IFNs) and pattern recognition receptor (PRR) expression in HBECs. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33710por Chaffey, Jessica R., Young, Jay, Leslie, Kaiyven A., Partridge, Katie, Akhbari, Pouria, Dhayal, Shalinee, Hill, Jessica L., Wedgwood, Kyle C. A., Burnett, Edward, Russell, Mark A., Richardson, Sarah J., Morgan, Noel G.“…Investigation of the molecular mechanisms suggested that this response was facilitated by a number of unexpected outcomes including an apparent failure of the cells to up-regulate certain anti-viral response gene products in response to interferons. However, more detailed exploration revealed that this lack of response was restricted to molecular targets that were either activated by, or detected with, human-selective reagents. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33711por Wu, Shan-Shan, Zhou, Qing-Xin, Zeng, Xue-Yang, Zhang, Jing-Xue, Yang, Zhi-Rong, Yang, Qing-Qing, Zhang, Zi-Lu, Chen, Ya-Hong, Sun, Feng, Zhan, Si-Yan“…TCM was associated with decreased risk of OAE (OR = 0.52, 95% CI: 0.38–0.70, very low quality) but CQ_HD (OR = 2.51, 95% CI: 1.20–5.24) and interferons (IFN) (OR = 2.69, 95% CI: 1.02–7.08) vs. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33712por Proskocil, Becky J., Wai, Karol, Lebold, Katherine M., Norgard, Mason A., Michaelis, Katherine A., De La Torre, Ubaldo, Cook, Madeline, Marks, Daniel L., Fryer, Allison D., Jacoby, David B., Drake, Matthew G.“…BACKGROUND: Toll-like receptor 7 (TLR7) is an innate immune receptor that detects viral single-stranded RNA and triggers the production of proinflammatory cytokines and type 1 interferons in immune cells. TLR7 agonists also modulate sensory nerve function by increasing neuronal excitability, although studies are conflicting whether sensory neurons specifically express TLR7. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33713The transcription factor reservoir and chromatin landscape in activated plasmacytoid dendritic cellspor Mann-Nüttel, Ritu, Ali, Shafaqat, Petzsch, Patrick, Köhrer, Karl, Alferink, Judith, Scheu, Stefanie“…Plasmacytoid dendritic cells (pDCs) are an immune cell type with the unique capacity to produce high amounts of type I interferons quickly in response to contact with viral components. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33714por Wray, Sibyl, Then Bergh, Florian, Wundes, Annette, Arnold, Douglas L., Drulovic, Jelena, Jasinska, Elzbieta, Bowen, James D., Negroski, Donald, Naismith, Robert T., Hunter, Samuel F., Gudesblatt, Mark, Chen, Hailu, Lyons, Jennifer, Shankar, Sai L., Kapadia, Shivani, Mendoza, Jason P., Singer, Barry A.“…Safety and efficacy were evaluated in a subset of newly enrolled patients who had received prior glatiramer acetate (GA; GA/DRF) or interferons (IFN; IFN/DRF) as their most recent DMT, prior to switching to DRF in EVOLVE-MS-1. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33715por Caccuri, Francesca, Messali, Serena, Bortolotti, Daria, Di Silvestre, Dario, De Palma, Antonella, Cattaneo, Chiara, Bertelli, Anna, Zani, Alberto, Milanesi, Maria, Giovanetti, Marta, Campisi, Giovanni, Gentili, Valentina, Bugatti, Antonella, Filippini, Federica, Scaltriti, Erika, Pongolini, Stefano, Tucci, Alessandra, Fiorentini, Simona, d’Ursi, Pasqualina, Ciccozzi, Massimo, Mauri, Pierluigi, Rizzo, Roberta, Caruso, Arnaldo“…This finding may be explained by a faster replicative activity of MB61(222) as compared to MB61(0) as well as by the capability of MB61(222) to induce peculiar viral RNA-sensing mechanisms leading to an increased production of interferons (IFNs) and, in particular, of IFN-induced transmembrane protein 1 (IFITM1) and IFITM2. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33716por Semple, Shawna L, Alkie, Tamiru N, Jenik, Kristof, Warner, Bryce M, Tailor, Nikesh, Kobasa, Darwyn, DeWitte-Orr, Stephanie J“…While the ability of type I interferons (IFNs) to limit coronavirus replication has been established, the ability of double-stranded (ds)RNA, a potent IFN inducer, to inhibit coronavirus replication when conjugated to a nanoparticle is largely unexplored. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33717por Hughes, Sean M., Levy, Claire N., Katz, Ronit, Lokken, Erica M., Anahtar, Melis N., Hall, Melissa Barousse, Bradley, Frideborg, Castle, Philip E., Cortez, Valerie, Doncel, Gustavo F., Fichorova, Raina, Fidel, Paul L., Fowke, Keith R., Francis, Suzanna C., Ghosh, Mimi, Hwang, Loris Y., Jais, Mariel, Jespers, Vicky, Joag, Vineet, Kaul, Rupert, Kyongo, Jordan, Lahey, Timothy, Li, Huiying, Makinde, Julia, McKinnon, Lyle R., Moscicki, Anna-Barbara, Novak, Richard M., Patel, Mickey V., Sriprasert, Intira, Thurman, Andrea R., Yegorov, Sergey, Mugo, Nelly Rwamba, Roxby, Alison C., Micks, Elizabeth, Hladik, Florian“…There was minimal change between the phases for CXCL8, 9, and 10, interferons, TNF, SLPI, elafin, lysozyme, lactoferrin, and interleukins 1β, 2, 10, 12, 13, and 17A. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33718por Hasan, Amal, Al-Ozairi, Ebaa, Hassan, Nosiba Y M, Ali, Shamsha, Ahmad, Rasheed, Al-Shatti, Nada, Alshemmari, Salem, Al-Mulla, Fahd“…Plasmacytoid dendritic cells (pDCs) are specialized in the rapid production of interferons in response to viral infections, and can also prime and activate T-cells. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33719por Tsai, Angela, Irrinki, Alivelu, Kaur, Jasmine, Cihlar, Tomas, Kukolj, George, Sloan, Derek D., Murry, Jeffrey P.“…Activation of TLR7 leads to the production of several stimulatory cytokines, including type I interferons (IFNs). In this study, we show that the selective TLR7 agonist GS-9620 induced HIV in peripheral blood mononuclear cells (PBMCs) from HIV-infected individuals on suppressive antiretroviral therapy. …”
Publicado 2017
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
33720por Maia Diniz, Isabela, Guerra, Augusto Afonso, Lovato Pires de Lemos, Livia, Souza, Kathiaja M., Godman, Brian, Bennie, Marion, Wettermark, Björn, de Assis Acurcio, Francisco, Alvares, Juliana, Gurgel Andrade, Eli Iola, Leal Cherchiglia, Mariangela, de Araújo, Vânia Eloisa“…The majority of the patients were female (73.3%), lived in the southeast region (58.9%), had a mean age of 36.8 (± 12.2) years and started treatment using one of the interferons beta (78.9%). The total direct medical cost spending in the sixteen years of the follow-up was US $ 2,308,393,465.60, and the mean annual expenditure per patient was US $ 13,544.40 (± 4,607.05). …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto