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381por Bonelli, Michael, Dalwigk, Karolina, Platzer, Alexander, Olmos Calvo, Isabel, Hayer, Silvia, Niederreiter, Birgit, Holinka, Johannes, Sevelda, Florian, Pap, Thomas, Steiner, Günter, Superti-Furga, Giulio, Smolen, Josef S., Kiener, Hans P., Karonitsch, Thomas“…Transcriptomic analyses of IRF1-deficient, TNF-stimulated FLSs define the interferon (IFN) pathway as a major target of IRF1. …”
Publicado 2019
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382por Abd Hamid, Megat, Yao, Xuan, Waugh, Craig, Rosendo-Machado, Samara, Li, Chris, Rostron, Timothy, Frankland, John, Peng, Yanchun, Dong, Tao“…Interferon gamma (IFNγ) supports effector responses of CD8(+) cytotoxic T lymphocytes (CTLs) and is a surrogate marker for detection of antigen-specific T cells. …”
Publicado 2020
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383por Wu, Chia-Min, Su, Fu-Hsiung, Muo, Chih-Hsin, Huang, Jou-Chen, Wu, Meei-Maan, Yeh, Chih-Ching“…This retrospective cohort study aims to investigate interferon (IFN)-associated retinopathy incidence in patients with chronic hepatitis C virus (HCV) infection treated with pegylated interferon (PegIFN) plus ribavirin (RBV). …”
Publicado 2021
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384por Cohan, Stanley L., Hendin, Barry A., Reder, Anthony T., Smoot, Kyle, Avila, Robin, Mendoza, Jason P., Weinstock-Guttman, Bianca“…Recombinant interferon (IFN) β-1b was approved by the US Food and Drug Administration as the first disease-modifying therapy (DMT) for multiple sclerosis (MS) in 1993. …”
Publicado 2021
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385por da Silva, Andréa Marques Vieira, Alvarado-Arnez, Lucia Elena, Azamor, Tamiris, Batista-Silva, Leonardo Ribeiro, Leal-Calvo, Thyago, Bezerra, Ohanna Cavalcanti de Lima, Ribeiro-Alves, Marcelo, Kehdy, Fernanda de Souza Gomes, Neves, Patrícia Cristina da Costa, Bayma, Camilla, da Silva, Jane, de Souza, Alessandro Fonseca, Muller, Marcelo, de Andrade, Elisabete Ferreira, Andrade, Ana Carolina Magalhães, dos Santos, Eliane Matos, Xavier, Janaína Reis, Maia, Maria De Lourdes De Sousa, Meireles, Rolando Páez, Cuni, Hugo Nodarse, Sander, Guilherme Becker, Picon, Paulo Dornelles, Matos, Denise C S, Moraes, Milton Ozório“…In this context, single nucleotide polymorphisms (SNPs) in the locus of interferon lambda 3 and 4 genes (IFNL3/4) have been important genetic markers of responsiveness to CHC as prognostic markers for the pegylated-Interferon-alpha/ribavirin (Peg-IFN-α/RBV). …”
Publicado 2021
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387por Stilp, Anne-Charlotte, Scherer, Myriam, König, Patrick, Fürstberger, Axel, Kestler, Hans A., Stamminger, Thomas“…Here, we show that depletion of ATRX results in an overall impaired antiviral state by decreasing transcription and subsequent secretion of type I IFNs, which is followed by reduced expression of interferon-stimulated genes (ISGs). ATRX interacts with the transcription factor interferon regulatory factor 3 (IRF3) and associates with the IFN-β promoter to facilitate transcription. …”
Publicado 2022
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388por Kim, Sonya T., Muñoz-Grajales, Carolina, Dunn, Shannon E., Schneider, Raphael, Johnson, Sindhu R., Touma, Zahi, Ahmad, Zareen, Bonilla, Dennisse, Atenafu, Eshetu G., Hiraki, Linda T., Bookman, Arthur, Wither, Joan“…BACKGROUND: Elevated levels of interferons (IFNs) are a characteristic feature of systemic autoimmune rheumatic diseases (SARDs) and may be useful in predicting impending symptomatic progression in anti-nuclear antibody-positive (ANA(+)) individuals lacking a SARD diagnosis. …”
Publicado 2023
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389por Hou, Lei, Shi, Yongyan, Guo, Jinshuo, Sun, Tong, Wang, Dedong, Yang, Xiaoyu, Liu, Changzhe, Cui, Yongqiu, Zhu, Ning, Tong, Xinxin, Pan, Yang, Feng, Xufei, Zhou, Jianwei, Liu, Jue“…When RNA viruses infect cells, viral RNA induces activation of retinoic acid-induced gene I and melanoma differentiation gene 5, which initiates downstream molecules and finally produces type I interferon (IFN-I) to regulate antiviral immune responses. …”
Publicado 2022
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390por Zeng, Yan-Ming, Xu, Xiao-Lei, He, Xiao-Qing, Tang, Sheng-Quan, Li, Yao, Huang, Yin-Qiu, Harypursat, Vijay, Chen, Yao-KaiEnlace del recurso
Publicado 2020
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391por Dimasuay, Kris Genelyn, Berg, Bruce, Schaunaman, Niccolette, Nichols, Taylor, Chu, Hong Wei“…BACKGROUND: Increased type 2 interferon (i.e., IFN-γ) signaling has been shown to be involved in airway inflammation in a subset of asthma patients who often show high levels of airway neutrophilic inflammation and poor response to corticosteroid treatment. …”
Publicado 2023
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392“…Interferon regulatory factor 7 (IRF7), a member of the interferon regulatory factors (IRFs) family, is located downstream of the pattern recognition receptors (PRRs)-mediated signaling pathway and is essential for the production of type I interferon (IFN-I). …”
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393“…Insufficient cytotoxic T lymphocyte infiltration and the accumulation of immunosuppressive cells within tumours are the primary factors responsible for the inadequate clinical effectiveness of breast cancer treatment. The stimulator of interferon genes (STING) represents a pivotal protein in the innate immune response. …”
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394por Rich, SheldonEnlace del recurso
Publicado 2003
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395por Varga, Kornél Z., Gyurina, Katalin, Radványi, Ádám, Pál, Tibor, Sasi-Szabó, László, Yu, Haidong, Felszeghy, Enikő, Szabó, Tamás, Röszer, Tamás“…Cytosolic DNA activates the stimulator of interferon response genes (STING), a key signal transducer which triggers type I interferon (IFN-I) expression; hence, STING activation is expected to induce IFN-I response and adipocyte dysfunction. …”
Publicado 2023
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396por Dimasuay, Kris Genelyn, Schaunaman, Niccolette, Berg, Bruce, Nichols, Taylor, Chu, Hong Wei“…Purpose: Increased type 2 interferon (i.e., IFN-γ) signaling has been shown to be involved in airway inflammation in a subset of asthma patients who often show high levels of airway neutrophilic inflammation and poor response to corticosteroid treatment. …”
Publicado 2023
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398por Albieri, Andréa, Hoshida, Mara S, Gagioti, Sonia M, Leanza, Eduardo C, Abrahamsohn, Ises, Croy, Anne, Ashkar, Ali A, Bevilacqua, Estela“…Interferon-gamma (IFN-gamma) mediates diverse functions in bone marrow-derived phagocytes, including phagocytosis and microbe destruction. …”
Publicado 2005
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399“…Patients with systemic lupus erythematosus (SLE) have ongoing interferon-α (IFN-α) production and serum IFN-α levels are correlated with both disease activity and severity. …”
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