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421“…Compelling support for a central role for interferon-alpha in lupus pathogenesis has led to a new focus on the role of innate immune system activation in the generation of pathogenic mediators. …”
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422por Witthöft, Th“…Consensus interferon (CIFN) is an artificially engineered interferon that reflects most of the human genotype 1 interferons and shows a higher biological and antiviral capacity in vitro. …”
Publicado 2008
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423“…BACKGROUND: Interferon has been widely used in the treatment of genital warts for its immunomodulatory, antiproliferative and antiviral properties. …”
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425por Farnsworth, Aaron, Flaman, Anathea S., Prasad, Shiv S., Gravel, Caroline, Williams, Andrew, Yauk, Carole L., Li, Xuguang“…BACKGROUND: Recombinant interferon treatment can result in several common side effects including fever and injection-site pain. …”
Publicado 2010
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426“…The clinical possibilities of interferon (IFN) became apparent with early studies demonstrating that it was capable of inhibiting tumor cells in culture and in vivo using animal models. …”
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427por Chen, S., Short, J.A.L., Young, D.F., Killip, M.J., Schneider, M., Goodbourn, S., Randall, R.E.“…The infection of cells by RNA viruses is associated with the recognition of virus PAMPs (pathogen-associated molecular patterns) and the production of type I interferon (IFN). To counter this, most, if not all, RNA viruses encode antagonists of the IFN system. …”
Publicado 2010
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428“…Since 1986, interferon-alfa (IFN-α) monotherapy has been administered for patients with chronic hepatitis C (CHC). …”
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429por Alrawi, Sadir J., Abo Deeb, Azza A., Samee, Mohammed, Raju, Ramanathan, Shirazian, Djamshid, Acinapura, Anthonay J., Cunningham, Joseph N.“…BACKGROUND: Gamma interferon (IFN-γ) is produced by activated natural killer and T cells under pathologic circumstances. …”
Publicado 2001
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430por Larocque, Louise, Bliu, Alex, Xu, Ranran, Diress, Abebaw, Wang, Junzhi, Lin, Rongtuan, He, Runtao, Girard, Michel, Li, Xuguang“…The traditional antiviral assays for the determination of interferon potency are reported to have considerable variability between and within assays. …”
Publicado 2011
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431por Hassan, K. M.Enlace del recurso
Publicado 2011
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432por HuangFu, Wei-Chun, Qian, Juan, Liu, Chengbao, Liu, Jianghuai, Lokshin, Anna E., Baker, Darren P., Rui, Hallgeir, Fuchs, Serge Y“…Interferon alpha (IFNα) is widely used for treatment of melanoma and certain other malignancies. …”
Publicado 2011
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433“…Like many animal viruses, those of the Rhabdoviridae family, are able to antagonize the type I interferon response and cause disease in mammalian hosts. …”
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434por Rönnblom, Lars“…Many patients with systemic autoimmune diseases have signs of a continuous production of type I interferon (IFN) and display an increased expression of IFN-α-regulated genes. …”
Publicado 2011
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435“…The discovery of the interferon-lambda (IFN-λ) family has considerably contributed to our understanding of the role of interferon not only in viral infections but also in cancer. …”
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436“…Here we summarize our current work on the negative regulation of osteoclastogenesis by unique signaling crosstalk between RANKL and interferons (IFNs). First, activated T cells maintain bone homeostasis by counterbalancing the action of RANKL through production of IFN-γ. …”
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437por Hensley, Lisa E., Fritz, Elizabeth A., Jahrling, Peter B., Karp, Christopher, Huggins, John W., Geisbert, Thomas W.“…Here, we report that recombinant human interferon (IFN)-β 1a potently inhibits SARS coronavirus replication in vitro.…”
Publicado 2004
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438“…Gene expression profiling and protein studies of the type I interferon pathway have revealed important insights into the disease process in adult and juvenile dermatomyositis. …”
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439“…To establish and maintain infection, KSHV has evolved unique mechanisms to evade the host immune response. Cellular interferon regulatory factors (IRFs) are a critical part of the host anti-viral immune response. …”
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