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461“…When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs (IFN-α and IFN-β) via the induction of IFN-stimulated genes (ISGs). …”
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462por Klok, Melanie D, Bakels, Hannah S, Postma, Nienke L, van Spaendonk, Rosalina M L, van der Knaap, Marjo S, Bugiani, Marianna“…Aicardi–Goutières syndrome is a leukoencephalopathy with calcifications and increased cerebrospinal fluid interferon-α. The relation between interferon-α and brain pathology is poorly understood. …”
Publicado 2015
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463por Kim, Seong-Yoon, Choi, Il-Yong, Kim, Sung-Joon, Kang, Chong-Myung, Lee, Chung-Kyun, Kim, Mok-Hyun“…Gamma interferon (IFN-γ) is a potent inducer of class II MHC antigens (la) in vitro. …”
Publicado 1987
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464por Chruewkamlow, Nuttapol, Mahasongkram, Kodchakorn, Pata, Supansa, Chaiwarith, Romanee, Salee, Parichart, Supparatpinyo, Khuanchai, Kasinrerk, Watchara“…Autoantibodies against interferon-gamma (IFN-γ) can cause immunodeficiency and are associated with various opportunistic infections. …”
Publicado 2016
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465por Teijaro, John R“…Type 1 interferons (IFN-I) exert pleiotropic biological effects during viral infections, all which contribute to balancing virus control and immune pathology. …”
Publicado 2016
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466por Kuo, Ping‐Chang, Scofield, Barbara A., Yu, I‐Chen, Chang, Fen‐Lei, Ganea, Doina, Yen, Jui‐Hung“…In >80% of strokes, the initial acute phase of ischemic injury is due to the occlusion of a blood vessel resulting in severe focal hypoperfusion, excitotoxicity, and oxidative damage. Interferon‐β (IFNβ), a cytokine with immunomodulatory properties, was approved by the US Food and Drug Administration for the treatment of relapsing‐remitting multiple sclerosis for more than a decade. …”
Publicado 2016
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467por Tan, Cindy S. E., Lawler, Clara, May, Janet S., Belz, Gabrielle T., Stevenson, Philip G.“…This indirect route entails exposure to host defences, and type I interferons (IFN-I) limit infection while viral evasion promotes it. …”
Publicado 2016
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468“…Very few reports of successful treatment of cutaneous mastocytosis using interferon alpha have been published.…”
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469por Huang, Ying-Hsien, Hsu, Yu-Wen, Lu, Hsing-Fang, Wong, Henry Sung-Ching, Yu, Hong-Ren, Kuo, Hsing-Chun, Huang, Fu-Chen, Chang, Wei-Chiao, Kuo, Ho-Chang“…IFNG gene encoding interferon (IFN)-γ, produced by natural killer cells and T cells, has been suggested to play an important role in the immunopathogenesis of Kawasaki disease. …”
Publicado 2016
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470“…The interferon (IFN)-λ family of type III cytokines includes the closely related interleukin (IL)-28A (IFN-λ2), IL-28B (IFN-λ3), and IL-29 (IFN-λ1). …”
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471por Horwitz, Marc S., Evans, Claire F., Mcgavern, Dorian B., Rodriguez, Moses, Oldstone, Michael B.A.“…Ever since the use of interferon-γ to treat patients with multiple sclerosis resulted in enhanced disease, the role of IFN-γ in demyelination has been under question. …”
Publicado 1997
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472“…Therefore, mechanisms to relay important signals regulating cell growth and immune reactivity must be in place to support GI homeostasis. Type I interferons (IFN-I) are a family of pleiotropic cytokines, which exert a wide range of biological effects including promotion of both pro- and anti-inflammatory activities. …”
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474“…Interferon alpha (IFN-α)-treated patients commonly develop depression during the therapy period. …”
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475por Chin, Kai Ling, Anis, Fadhilah Zulkipli, Sarmiento, Maria E., Norazmi, Mohd Nor, Acosta, Armando“…Host immune response to Mtb is influenced by interferon- (IFN-) signaling pathways, particularly by type I and type II interferons (IFNs). …”
Publicado 2017
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476por Moritz, Kasey E., McCormack, Nikki M., Abera, Mahlet B., Viollet, Coralie, Yauger, Young J., Sukumar, Gauthaman, Dalgard, Clifton L., Burnett, Barrington G.“…Using gene expression analysis and native gel electrophoresis we characterize the expression and assembly of the immunoproteasome in microglia following interferon-gamma exposure. Transcriptome analysis suggests that the immunoproteasome regulates multiple features of microglial activation including nitric oxide production and phagocytosis. …”
Publicado 2017
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477“…BACKGROUND: Methylation of a CpG island (CGI; a dense cluster of CpGs) located in the 5' region of a gene suppresses transcription of that gene. Interferon regulatory factor 6 (IRF6) is associated with the expression of interferon, which is used as an effective adjuvant therapy for melanoma, and is regarded as a tumor suppressor. …”
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478“…African trypanosomes cause fatal infections in both humans and livestock. Interferon gamma (IFN-γ) plays an essential role in resistance to African trypanosomes. …”
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479“…Nucleic acids derived from pathogens or from certain cellular conditions represent a large category of PAMPs/DAMPs that trigger production of type I interferons (IFN-I) in addition to pro-inflammatory cytokines, by specifically binding to intracellular Toll-like receptors or cytosolic receptors. …”
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480“…Type III interferons, also known as interferon lambdas (IFNλs), are the most recent addition to the IFN family following their discovery in 2003. …”
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