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521por Blaauboer, Amber, Booy, Stephanie, van Koetsveld, Peter M., Karels, Bas, Dogan, Fadime, van Zwienen, Suzanne, van Eijck, Casper H. J., Hofland, Leo J.“…We aimed to evaluate the chemosensitising effect of interferon-beta (IFN-β). METHODS: BxPC-3, CFPAC-1, and Panc-1 cells were pre-treated with IFN-β followed by gemcitabine monotherapy. …”
Publicado 2020
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522por Rich, Helen E., Antos, Danielle, Melton, Natalie R., Alcorn, John F., Manni, Michelle L.“…Regardless of asthma severity and adequate disease management, patients may experience acute exacerbations of symptoms and a loss of disease control, often triggered by respiratory infections. The interferon (IFN) family represents a group of cytokines that play a central role in the protection against and exacerbation of various infections and pathologies, including asthma. …”
Publicado 2020
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523“…Here, we critically address the bidirectional interplay between interferons (focusing on type I) and cell senescence, with important implications for health and healthspan.…”
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524por Gupta, RahulEnlace del recurso
Publicado 2020
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525por Haji Abdolvahab, Mohadeseh, Moradi-kalbolandi, Shima, Zarei, Mohammad, Bose, Deepanwita, Majidzadeh-A, Keivan, Farahmand, Leila“…Treatment is principally supportive; however, there are several agents that are using in treating of COVID-19 patients. Interferons (IFNs) have shown to be crucial in fighting with COVID-19 disease and can be a suitable candidate in treatment of these patients. …”
Publicado 2021
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526“…Cellular innate immune responses, mainly interferon (IFN) response, are crucial for controlling invading viruses, while viruses counteract these responses to favor their propagation. …”
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527por Rother, Nils, Yanginlar, Cansu, Lindeboom, Rik G.H., Bekkering, Siroon, van Leent, Mandy M.T., Buijsers, Baranca, Jonkman, Inge, de Graaf, Mark, Baltissen, Marijke, Lamers, Lieke A., Riksen, Niels P., Fayad, Zahi A., Mulder, Willem J.M., Hilbrands, Luuk B., Joosten, Leo A.B., Netea, Mihai G., Vermeulen, Michiel, van der Vlag, Johan, Duivenvoorden, Raphaël“…In this model, hydroxychloroquine inhibits the responsiveness of these innate immune cells to virus-like stimuli and interferons. This is associated with a suppression of histone 3 lysine 27 acetylation and histone 3 lysine 4 trimethylation of inflammation-related genes, changes in the cellular lipidome, and decreased expression of interferon-stimulated genes. …”
Publicado 2020
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528“…Innate immune interferons (IFNs), including type I and III IFNs, constitute critical antiviral mechanisms. …”
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529por Zanin, Natacha, Viaris de Lesegno, Christine, Lamaze, Christophe, Blouin, Cedric M.“…Like most plasma membrane proteins, type I interferon (IFN) receptor (IFNAR) traffics from the outer surface to the inner compartments of the cell. …”
Publicado 2021
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530“…Key to these responses are type I, II, and III interferons (IFNs), which are involved in inducing an antiviral response, as well as controlling and suppressing inflammation and immunopathology. …”
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531por Castro, Leonor S., Lobo, Guilherme S., Pereira, Patrícia, Freire, Mara G., Neves, Márcia C., Pedro, Augusto Q.“…Among promising biopharmaceuticals are interferons, first described by Isaacs and Lindenmann in 1957 and approved for clinical use in humans nearly thirty years later. …”
Publicado 2021
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532“…Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I and III interferon (IFN) responses act as the first line of defense against viral infection and are activated by the recognition of viruses by infected cells and innate immune cells. …”
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533por Dorgham, Karim, Neumann, Avidan U., Decavele, Maxens, Luyt, Charles-Edouard, Yssel, Hans, Gorochov, GuyEnlace del recurso
Publicado 2021
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534por Decker, Thomas“…Interferons establish innate antiviral immunity. Two recent papers in JEM by Lopez et al. (2021. …”
Publicado 2021
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535por Leibowitz, Brian J., Zhao, Guangyi, Wei, Liang, Ruan, Hang, Epperly, Michael, Chen, Lujia, Lu, Xinghua, Greenberger, Joel S., Zhang, Lin, Yu, Jian“…Here, we report that cGAS-STING–dependent type 1 interferon (IFN) response drives intestinal regeneration and animal recovery from radiation injury. …”
Publicado 2021
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536“…In this issue, van Laarhoven et al.(1) describe five immunocompromised patients with prolonged COVID-19 successfully treated with interferon gamma (IFNγ).…”
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537“…Interferons are our first line of defense against invading viruses. …”
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538por Akamatsu, Milena Apetito, de Castro, Júlia Tavares, Takano, Carolina Yumi, Ho, Paulo Lee“…Interferons are innate and adaptive cytokines involved in many biological responses, in particular, viral infections. …”
Publicado 2021
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539“…Recent evidence suggests the existence of a nexus between inflammatory pathways and the female sex hormone 17β-estradiol, resulting in increased interferon-stimulated genes (ISGs), autoantibodies, and dysregulation of immune cells in SLE. …”
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540“…Psoriasis is a chronic inflammatory disease that involves both the innate and adaptive immune systems. Type I interferons (IFNs), the production of which is partially regulated by toll-like receptors (TLRs), play an important role in the pathogenesis of psoriasis, especially psoriasis caused by skin trauma, known as the Koebner phenomenon. …”
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