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541“…In this review, we provide a concise overview of the evidence establishing the significance of type I and type III interferon (IFN) responses in the restriction of noroviruses. …”
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542por Kazakov, Alexey S., Sofin, Alexander D., Avkhacheva, Nadezhda V., Deryusheva, Evgenia I., Rastrygina, Victoria A., Permyakova, Maria E., Uversky, Vladimir N., Permyakov, Eugene A., Permyakov, Sergei E.“…Interferon-β (IFN-β) is a pleiotropic cytokine secreted in response to various pathological conditions and is clinically used for therapy of multiple sclerosis. …”
Publicado 2022
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543“…IL-27 contributes to the immune response against viruses indirectly by increasing production of interferons (IFNs) which have various antiviral effects. …”
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544
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545“…Interferon (IFN)-α is a cytokine that exhibits a wide range of biological activities and is used in various cancer treatments. …”
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546“…Ropeginterferon alfa-2b is a novel mono-pegylated and extra-long-acting interferon, being developed for the treatment of myeloproliferative neoplasm (MPN) and chronic viral hepatitis. …”
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547por Peng, Zhouyangfan, Duan, Mingwu, Tang, Yiting, Wu, Jianfeng, Zhao, Kai, Zhong, Yanjun, He, Zhihui, Meng, Jie, Chen, Fangping, Xiao, Xianzhong, Wang, Haichao, Billiar, Timothy R., Lu, Ben, Liang, Fang“…Global or myeloid cell-specific deletion of interferon γ receptor (IFN-γR) markedly enhanced the crystalline silica-induced pulmonary injury in wild-type but not in NLRP3 deficient mice. …”
Publicado 2022
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548
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549por Sattarnezhad, Neda, Healy, Brian C., Baharnoori, Moogeh, Diaz-Cruz, Camilo, Stankiewicz, James, Weiner, Howard L., Chitnis, Tanuja“…BACKGROUND: To compare the effectiveness of dimethyl fumarate (DMF) with subcutaneous interferon beta-1a (IFNβ-1a) in controlling disease activity in patients with relapsing–remitting Multiple Sclerosis (MS). …”
Publicado 2022
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550“…The detection of pathogen-associated molecular patterns can elicit the production of type-I interferons (IFNs), soluble cytokines that induce a transcriptional state inhibitory to viral replication. …”
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551“…The interferon (IFN) response is the major early innate immune response against invading viral pathogens and is even capable of mediating sterilizing antiviral immunity without the support of the adaptive immune system. …”
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552por Ng, Simon, Lim, Shuhui, Sim, Adrian Chong Nyi, Mangadu, Ruban, Lau, Ally, Zhang, Chunsheng, Martinez, Sarah Bollinger, Chandramohan, Arun, Lim, U-Ming, Ho, Samantha Shu Wen, Chang, Shih Chieh, Gopal, Pooja, Hong, Lewis Z., Schwaid, Adam, Fernandis, Aaron Zefrin, Loboda, Andrey, Li, Cai, Phan, Uyen, Henry, Brian, Partridge, Anthony W.“…Herein, we report an under-appreciated role of STUB1 to dampen the interferon gamma (IFNγ) response. Genetic deletion of STUB1 increased IFNGR1 abundance on the cell surface and thus enhanced the downstream IFNγ response as showed by multiple approaches including Western blotting, flow cytometry, qPCR, phospho-STAT1 assay, immunopeptidomics, proteomics, and gene expression profiling. …”
Publicado 2022
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553por Kawali, Ankush, Sanjay, Srinivasan, Mohan, Ashwin, Mahendradas, Padmamalini, Shroff, Sujani, Shetty, Rohit“…PURPOSE: To evaluate the efficacy of intensive topical interferon alfa-2b (IFN) therapy in uveitic macular edema (UME). …”
Publicado 2022
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554por Liu, Taiqing, Li, Yinqi, Wang, Xiaoyu, Yang, Xiaodong, Fu, Yunhai, Zheng, Yeteng, Gong, Hanlin, He, Zhiyao“…The OC microenvironment is regulated by Interferons (IFNs) known as a type of important cytokines. …”
Publicado 2022
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555“…BACKGROUND: IRF9 is a transcription factor that mediates the expression of interferon-stimulated genes (ISGs) through the Janus kinase-Signal transducer and activator of transcription (JAK-STAT) pathway. …”
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556“…Autoantibody formation and immune complex formation are important mediators in lupus pathogenesis, but an important role of the type I interferon (IFN) pathway has been identified in SLE patients and mouse models of lupus. …”
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557por Reis, Gilmar, Moreira Silva, Eduardo A.S., Medeiros Silva, Daniela C., Thabane, Lehana, Campos, Vitoria H.S., Ferreira, Thiago S., Santos, Castilho V.Q., Nogueira, Ana M.R., Almeida, Ana P.F.G., Savassi, Leonardo C.M., Figueiredo-Neto, Adhemar D., Dias, Ana C.F., Freire Júnior, Adelino M., Bitarães, Carina, Milagres, Aline C., Callegari, Eduardo D., Simplicio, Maria I.C., Ribeiro, Luciene B., Oliveira, Rosemary, Harari, Ofir, Wilson, Lindsay A., Forrest, Jamie I., Ruton, Hinda, Sprague, Sheila, McKay, Paula, Guo, Christina M., Limbrick-Oldfield, Eve H., Kanters, Steve, Guyatt, Gordon H., Rayner, Craig R., Kandel, Christopher, Biondi, Mia J., Kozak, Robert, Hansen, Bettina, Zahoor, M. Atif, Arora, Paul, Hislop, Colin, Choong, Ingrid, Feld, Jordan J., Mills, Edward J., Glenn, Jeffrey S.“…BACKGROUND: The efficacy of a single dose of pegylated interferon lambda in preventing clinical events among outpatients with acute symptomatic coronavirus disease 2019 (Covid-19) is unclear. …”
Publicado 2023
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558por Gur, Ali, Dikici, Bünyamin, Nas, Kemal, Bosnak, Mehmet, Haspolat, Kenan, Sarac, Aysegul Jale“…BACKGROUND: Our aim was to determinate bone mineral density (BMD), levels of biochemical markers and cytokines in children with chronic hepatitis B treated with interferon (IFN)-alpha and to investigate effect of IFN-alpha therapy on these variables. …”
Publicado 2005
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559por Cousens, Leslie P., Peterson, Ron, Hsu, Sang, Dorner, Andrew, Altman, John D., Ahmed, Rafi, Biron, Christine A.“…Viral infections induce CD8 T cell expansion and interferon (IFN)-γ production for defense, but the innate cytokines shaping these responses have not been identified. …”
Publicado 1999
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560por Shah, Khilan M., Stewart, Suzanne E, Wei, Wenbin, Woodman, Ciaran B J, O’Neil, John D, Dawson, Christopher W., Young, Lawrence S“…Here we demonstrate a novel function for these proteins in epithelial cells, namely, their ability to modulate signalling from type I/II interferon receptors (IFNRs). We show that LMP2A and LMP2B-expressing epithelial cells display decreased responsiveness to interferon (IFN)α and IFNγ, as assessed by STAT1 phosphorylation, ISGF3 and GAF-mediated binding to ISRE and GAS elements and luciferase reporter activation. …”
Publicado 2009
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