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621por Jones, D. H., Bleehen, N. M., Slater, A. J., George, P. J., Walker, J. R., Dixon, A. K.“…Ten patients with small cell lung cancer were treated with high dose human lymphoblastoid interferon (50-100 megaunits m-2) for 5 days, followed by low dose interferon (3 megaunits m-2) for 3 weeks. …”
Publicado 1983
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622“…This paper describes the clinical course of a patient with chronic hepatitis C, genotype 2a/2c, previously treated with Interferon α2b and subsequently with Lymphoblastoid Interferon without any response, and also without any cutaneous side effects. …”
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623Publicado 1979“…The genetically determined resistance towards orthomyxoviruses exhibited by mice homozygous (A2G) or heterozygous (A2G X A/J) for the gene Mx was abolished or greatly diminished by treatment with anti- interferon globulin (AIF). AIF induced increased susceptibility to challenge with hepatotropic, neurotropic, and pneumotropic strains of influenza A virus. …”
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624Publicado 1982“…Interferon (IFN) was found to be secreted by cloned lines of murine cytotoxic T lymphocytes in response to mitogenic or antigen specific stimulation. …”
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625Publicado 1982“…To determine the chromosomal location of the human alpha interferon genes, we scored a series of human/rodent somatic cell hybrids for the presence of DNA sequences hybridizing to an alpha 1 interferon DNA probe. …”
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626“…We have described in this paper a novel human interferon (IFN) with antigenic and cross-species reactivity of α-IFN and physicochemical properties of γ-IFN. …”
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627Publicado 1984“…Southern blot analysis with a murine interferon-alpha2 (MuIFN-alpha2) cDNA probe revealed restriction fragment polymorphism of EcoRI- and HindIII-digested C57BL/6 and BALB/cDNA. …”
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628Publicado 1984“…In contrast to recombinant interferon-gamma (rIFN gamma), the following factors, tested in partially or highly purified form and over a wide range of concentrations, did not augment these functions: native interferon- alpha (nIFN alpha), rIFN alpha A, rIFN alpha D, rIFN beta, colony stimulating factor (type 1) (CSF-1), CSF for granulocytes and macrophages (GM-CSF), pluripotent CSF (p-CSF), tumor necrosis factor (TNF), native interleukin 2 (nIL-2), and rIL-2. …”
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629Publicado 1985“…Interferon (IFN) pretreatment of low-passage mouse embryonic fibroblasts (MEF) infected with lymphocytic choriomeningitis virus or vaccinia virus rendered these cells two to three times more susceptible to lysis by H-2 restricted, virus-specific cytotoxic T lymphocytes (CTL) than control, virus-infected MEF. …”
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630
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631Publicado 1993“…The increased susceptibility of immunocompromised individuals to tuberculosis, and many experimental studies indicate that T cell- mediated immunity plays an important role in resistance. The lymphokine interferon gamma (IFN-gamma) is thought to be a principal mediator of macrophage activation and resistance to intracellular pathogens. …”
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632Publicado 1994“…Antibody neutralization studies have established interferon gamma (IFN- gamma) as a critical mediator of endotoxic shock. …”
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633por Wang, Zhongde, Zheng, Tao, Zhu, Zhou, Homer, Robert J., Riese, Richard J., Chapman, Harold A., Shapiro, Steven D., Elias, Jack A.“…Here we demonstrate that interferon γ (IFN-γ), a prominent product of CD8(+) cells, causes emphysema with alveolar enlargement, enhanced lung volumes, enhanced pulmonary compliance, and macrophage- and neutrophil-rich inflammation when inducibly targeted, in a transgenic fashion, to the adult murine lung. …”
Publicado 2000
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634por Zhang, Yongkang, Apilado, Ron, Coleman, John, Ben-Sasson, Shlomo, Tsang, Sharon, Hu-Li, Jane, Paul, William E., Huang, Hua“…However, such restimulation of Th1-primed cells from interferon (IFN)-γ(2/−) or IFN-γ receptor (IFN-γR)(−/−) mice resulted in substantial production of IL-4 and other Th2 cytokines. …”
Publicado 2001
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635por Enzler, Thomas, Gillessen, Silke, Manis, John P., Ferguson, David, Fleming, James, Alt, Frederick W., Mihm, Martin, Dranoff, Glenn“…Concurrent deficiency of interferon (IFN)-γ attenuates the SLE, but promotes the formation of diverse hematologic and solid neoplasms within a background of persistent infection and inflammation. …”
Publicado 2003
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636“…Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs) that respond to most viruses. Because of their antiviral activity and regulatory functions in innate and adaptive immunity, type I IFNs are important not only for antiviral resistance but also in other types of infections and in immune pathology. …”
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637
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638por Li, Q, Zhang, X-q, Nie, L, Chen, G-s, Li, H, Zhang, F, Zhang, L-y, Hong, L, Wang, S-f, Wang, H“…It is known that interferon-γ (IFN-γ) is produced by activated T and NK lymphoid cells, mononuclear cells, and macrophage and dendritic cells. …”
Publicado 2007
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639por Muñoz-Fontela, César, Macip, Salvador, Martínez-Sobrido, Luis, Brown, Lauren, Ashour, Joseph, García-Sastre, Adolfo, Lee, Sam W., Aaronson, Stuart A.“…Nature. 424:516–523) have shown that p53 is also induced in response to viral infections as a downstream transcriptional target of type I interferon (IFN) signaling. Moreover, many viruses, including SV40, human papillomavirus, Kaposi's sarcoma herpesvirus, adenoviruses, and even RNA viruses such as polioviruses, have evolved mechanisms designated to abrogate p53 responses. …”
Publicado 2008
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640por Herrmann, Jean-Louis, Belloy, Marie, Porcher, Raphael, Simonney, Nancy, Aboutaam, Rola, Lebourgeois, Muriel, Gaudelus, Joel, De LosAngeles, Laure, Chadelat, Katarina, Scheinmann, Pierre, Beydon, Nicole, Fauroux, Brigitte, Bingen, Martine, Terki, Mustapha, Barraud, Dominique, Cruaud, Philippe, Offredo, Catherine, Ferroni, Agnes, Berche, Patrick, Moissenet, Didier, Vuthien, Hoang, Doit, Catherine, Bingen, Edouard, Lagrange, Philippe Henri“…BACKGROUND: Development of T-cells based-Interferon gamma (IFNγ) assays has offered new possibilities for the diagnosis of latent tuberculosis infection (LTBI) and active disease in adults. …”
Publicado 2009
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