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  1. 621
    “…Ten patients with small cell lung cancer were treated with high dose human lymphoblastoid interferon (50-100 megaunits m-2) for 5 days, followed by low dose interferon (3 megaunits m-2) for 3 weeks. …”
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    Human lymphoblastoid interferon in the treatment of small cell lung cancer.
  2. 622
    “…This paper describes the clinical course of a patient with chronic hepatitis C, genotype 2a/2c, previously treated with Interferon α2b and subsequently with Lymphoblastoid Interferon without any response, and also without any cutaneous side effects. …”
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    Extensive psoriasis induced by pegylated interferon: a case report
  3. 623
    Publicado 1979
    “…The genetically determined resistance towards orthomyxoviruses exhibited by mice homozygous (A2G) or heterozygous (A2G X A/J) for the gene Mx was abolished or greatly diminished by treatment with anti- interferon globulin (AIF). AIF induced increased susceptibility to challenge with hepatotropic, neurotropic, and pneumotropic strains of influenza A virus. …”
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    Genetically determined, interferon-dependent resistance to influenza virus in mice
  4. 624
    Publicado 1982
    “…Interferon (IFN) was found to be secreted by cloned lines of murine cytotoxic T lymphocytes in response to mitogenic or antigen specific stimulation. …”
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    Cytotoxic T lymphocytes produce immune interferon in response to antigen or mitogen
  5. 625
    Publicado 1982
    “…To determine the chromosomal location of the human alpha interferon genes, we scored a series of human/rodent somatic cell hybrids for the presence of DNA sequences hybridizing to an alpha 1 interferon DNA probe. …”
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    Chromosomal location of a human alpha interferon gene family
  6. 626
    “…We have described in this paper a novel human interferon (IFN) with antigenic and cross-species reactivity of α-IFN and physicochemical properties of γ-IFN. …”
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    Immune human lymphocytes produce an acid-labile α-interferon
  7. 627
    Publicado 1984
    “…Southern blot analysis with a murine interferon-alpha2 (MuIFN-alpha2) cDNA probe revealed restriction fragment polymorphism of EcoRI- and HindIII-digested C57BL/6 and BALB/cDNA. …”
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    Linkage analysis of the murine interferon-alpha locus on chromosome 4
  8. 628
    Publicado 1984
    “…In contrast to recombinant interferon-gamma (rIFN gamma), the following factors, tested in partially or highly purified form and over a wide range of concentrations, did not augment these functions: native interferon- alpha (nIFN alpha), rIFN alpha A, rIFN alpha D, rIFN beta, colony stimulating factor (type 1) (CSF-1), CSF for granulocytes and macrophages (GM-CSF), pluripotent CSF (p-CSF), tumor necrosis factor (TNF), native interleukin 2 (nIL-2), and rIL-2. …”
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    Activation of human macrophages. Comparison of other cytokines with interferon-gamma
  9. 629
    Publicado 1985
    “…Interferon (IFN) pretreatment of low-passage mouse embryonic fibroblasts (MEF) infected with lymphocytic choriomeningitis virus or vaccinia virus rendered these cells two to three times more susceptible to lysis by H-2 restricted, virus-specific cytotoxic T lymphocytes (CTL) than control, virus-infected MEF. …”
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    Interferon enhances the susceptibility of virus-infected fibroblasts to cytotoxic T cells
  10. 630
    Publicado 1989
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    Gamma interferon limits access of Listeria monocytogenes to the macrophage cytoplasm
  11. 631
    Publicado 1993
    “…The increased susceptibility of immunocompromised individuals to tuberculosis, and many experimental studies indicate that T cell- mediated immunity plays an important role in resistance. The lymphokine interferon gamma (IFN-gamma) is thought to be a principal mediator of macrophage activation and resistance to intracellular pathogens. …”
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    An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection
  12. 632
    Publicado 1994
    “…Antibody neutralization studies have established interferon gamma (IFN- gamma) as a critical mediator of endotoxic shock. …”
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    Interferon gamma receptor deficient mice are resistant to endotoxic shock
  13. 633
    “…Here we demonstrate that interferon γ (IFN-γ), a prominent product of CD8(+) cells, causes emphysema with alveolar enlargement, enhanced lung volumes, enhanced pulmonary compliance, and macrophage- and neutrophil-rich inflammation when inducibly targeted, in a transgenic fashion, to the adult murine lung. …”
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    Interferon γ Induction of Pulmonary Emphysema in the Adult Murine Lung
  14. 634
    “…However, such restimulation of Th1-primed cells from interferon (IFN)-γ(2/−) or IFN-γ receptor (IFN-γR)(−/−) mice resulted in substantial production of IL-4 and other Th2 cytokines. …”
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    Interferon γ Stabilizes the T Helper Cell Type 1 Phenotype
  15. 635
    “…Concurrent deficiency of interferon (IFN)-γ attenuates the SLE, but promotes the formation of diverse hematologic and solid neoplasms within a background of persistent infection and inflammation. …”
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    Deficiencies of GM-CSF and Interferon γ Link Inflammation and Cancer
  16. 636
    “…Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs) that respond to most viruses. Because of their antiviral activity and regulatory functions in innate and adaptive immunity, type I IFNs are important not only for antiviral resistance but also in other types of infections and in immune pathology. …”
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    Production of type I interferons: plasmacytoid dendritic cells and beyond
  17. 637
    por Gaudillière, Jean-Paul
    Publicado 2008
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    Book Review: Interferon: the science and selling of a miracle drug
  18. 638
    “…It is known that interferon-γ (IFN-γ) is produced by activated T and NK lymphoid cells, mononuclear cells, and macrophage and dendritic cells. …”
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    Expression of interferon-γ in human adrenal gland and kidney tumours
  19. 639
    “…Nature. 424:516–523) have shown that p53 is also induced in response to viral infections as a downstream transcriptional target of type I interferon (IFN) signaling. Moreover, many viruses, including SV40, human papillomavirus, Kaposi's sarcoma herpesvirus, adenoviruses, and even RNA viruses such as polioviruses, have evolved mechanisms designated to abrogate p53 responses. …”
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    Transcriptional role of p53 in interferon-mediated antiviral immunity
  20. 640
    “…BACKGROUND: Development of T-cells based-Interferon gamma (IFNγ) assays has offered new possibilities for the diagnosis of latent tuberculosis infection (LTBI) and active disease in adults. …”
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    Temporal Dynamics of Interferon Gamma Responses in Children Evaluated for Tuberculosis
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