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681“…Vertebrate interferon-induced transmembrane (IFITM) genes have been demonstrated to have extensive and diverse functions, playing important roles in the evolution of vertebrates. …”
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682por Yamasaki, Kazumi, Tomohiro, Mayumi, Nagao, Yumiko, Sata, Michio, Shimoda, Toshiaki, Hirase, Kazuhiro, Shirahama, Satoshi“…BACKGROUND: No study has compared the long-term prognoses of hepatitis C patients with hepatitis C virus (HCV) antibody-negative individuals and investigated the effects of interferon (IFN) treatment. To clarify the long-term prognosis of HCV-positive residents of an isolated Japanese island and prospectively investigate the effects of IFN treatment in comparison with the HCV-negative general population. …”
Publicado 2012
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683“…Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple genetic risk factors, high levels of interferon alpha (IFN-α), and the production of autoantibodies against components of the cell nucleus. …”
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685“…The first disease-specific agent licensed to treat multiple sclerosis (MS) was interferon-β (IFNβ). In its various preparations, it remains the most commonly used first-line agent. …”
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686“…The type I interferon (IFN) system mediates a wide variety of antiviral effects and represents an important first barrier to virus infection. …”
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688por Coulstock, Edward, Sosabowski, Jane, Ovečka, Milan, Prince, Rob, Goodall, Laura, Mudd, Clare, Sepp, Armin, Davies, Marie, Foster, Julie, Burnet, Jerome, Dunlevy, Gráinne, Walker, Adam“…Interferon alpha (IFNα) is used for the treatment of hepatitis C infection and whilst efficacious it is associated with multiple adverse events including reduced leukocyte, erythrocyte, and platelet counts, fatigue, and depression. …”
Publicado 2013
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689por Zhou, Xiang, Michal, Jennifer J., Zhang, Lifan, Ding, Bo, Lunney, Joan K., Liu, Bang, Jiang, Zhihua“…Secretion of interferons (IFNs) from virus-infected cells is a hallmark of host antiviral immunity and in fact, IFNs exert their antiviral activities through the induction of antiviral proteins. …”
Publicado 2013
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690“…Due to the side effect profile of pegylated interferons, interferon-sparing regimens have become the main target in chronic hepatitis C treatment research. …”
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691The Role of Plasmacytoid Dendritic Cells and Interferon-Alpha in the Immunopathogenesis of Psoriasispor Denadai, RafaelEnlace del recurso
Publicado 2013
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692“…Treatment for chronic myeloid leukemia (CML) has evolved from chemotherapy (busulfan, hydroxyurea) to interferon-α (IFNα), and finally to tyrosine kinase inhibitors such as imatinib. …”
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693por Park, Joon, Munagala, Indira, Xu, Hui, Blankenship, Derek, Maffucci, Patrick, Chaussabel, Damien, Banchereau, Jacques, Pascual, Virginia, Cunningham-Rundles, CharlotteEnlace del recurso
Publicado 2013
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694“…Advanced renal cancer is an incurable malignancy in need of novel therapeutic avenues. We have generated interferon γ (IFNγ)-based fusion antibodies (immunocytokines) that target CD70, a putative biomarker of renal cancer. …”
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695por Cho, Hyun Chin, Gwak, Geum-Youn, Paik, Yong Han, Choi, Moon Seok, Lee, Joon Hyeok, Koh, Kwang Cheol, Yoo, Byung Chul, Paik, Seung Woon“…BACKGROUND/AIMS: Pegylated interferon (peginterferon) and ribavirin is the current standard therapy for chronic hepatitis C. …”
Publicado 2013
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696“…Interferon-γ (IFNγ) plays various roles in the pathogenesis of HIV/AIDS. …”
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697por Wang, Ding, Zhong, Xuan, Huang, Dongjian, Chen, Rui, Bai, Guibin, Li, Qing, Yu, Bolan, Fan, Yong, Sun, Xiaofang“…OBJECTIVE: Sepsis is an inflammatory syndrome caused by infection, and both its incidence and mortality are high. Because interferon-gamma (IFN-γ) plays an important role in inflammation, this work assessed IFN-γ single nucleotide polymorphism (SNPs) that may be associated with sepsis. …”
Publicado 2014
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698por Keshvari, Maryam, Alavian, Seyed Moayed, Sharafi, Heidar, Karimi, Gharib, Gholami Fesharaki, Mohammad“…The only approved therapy for chronic hepatitis delta is interferon alpha (IFN α) in either pegylated or conventional forms. …”
Publicado 2014
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699por Huang, Cheng, Walker, Aida G., Grant, Ashley M., Kolokoltsova, Olga A., Yun, Nadezhda E., Seregin, Alexey V., Paessler, Slobodan“…We have reported that interferon receptor knockout mice succumb to JUNV infection, indicating the critical role of interferon in restricting JUNV infection in mice. …”
Publicado 2014
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