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761“…Replication of cardioviruses produces double stranded RNA that is detected by helicases in the RIG-I-like receptor family and leads to a signaling cascade to produce type I interferon. Like other viruses within Picornaviridae, however, cardioviruses have evolved several mechanisms to inhibit interferon production. …”
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762por Jang, Yong Ju, Lim, Ji Youn, Kim, Seoyeon, Lee, Yoo La, Kweon, Mi-Na, Kim, Ji Heui“…Type I interferon (IFN-I, including IFN-α and IFN-β) response has been implicated in eosinophilic inflammation, in addition to antiviral function. …”
Publicado 2018
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763por Hefter, Yosefa, D’Arco, Christina, Shute, Travis, Dattwyler, Raymond, Arnaboldi, Paul, Nolan, SheilaEnlace del recurso
Publicado 2018
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764por Knuth, Anne-Kathrin, Rösler, Stefanie, Schenk, Barbara, Kowald, Lisa, van Wijk, Sjoerd J.L., Fulda, Simone“…Interferons (IFNs) are key players in the tumor immune response and act by inducing the expression of IFN-stimulated genes (ISGs). …”
Publicado 2018
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765por Burbelo, Peter D., Browne, Sarah, Holland, Steve M., Iadarola, Michael J., Alevizos, Ilias“…CONCLUSION: Overall, these findings demonstrate that a subset of SS patients (16%) harbor autoantibodies against GMCSF, interferon-γ, interferon-ω, and interferon-α. These data support the observation that high levels of interferon-α autoantibodies may attenuate disease symptoms in SS.…”
Publicado 2019
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766“…Type I interferon (IFN-I) is the first line of mammalian host defense against viral infection. …”
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767“…In particular, this model has clarified the central roles that type I interferons play in initiating and regulating host responses. …”
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768“…In an attempt to better understand the pathogenesis of AMD, in this study, we evaluated the serum interferon (IFN) levels in patients with AMD and compared it with persons without AMD. …”
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769por Dowell, N.G., Bouyagoub, S., Tibble, J., Voon, V., Cercignani, M., Harrison, N.A.“…Interferon-alpha (IFN-α) is an important mediator of antiviral immune responses. …”
Publicado 2019
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770“…Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation and immune response by directly inducing anti-pathogen molecular countermeasures. …”
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771por Cecco, Marco De, Ito, Takahiro, Petrashen, Anna P., Elias, Amy E., Skvir, Nicholas J., Criscione, Steven W., Caligiana, Alberto, Brocculi, Greta, Adney, Emily M., Boeke, Jef D., Le, Oanh, Beauséjour, Christian, Ambati, Jayakrishna, Ambati, Kameshwari, Simon, Matthew, Seluanov, Andrei, Gorbunova, Vera, Slagboom, P. Eline, Helfand, Stephen L., Neretti, Nicola, Sedivy, John M.“…Here we show that during cellular senescence LINE-1 elements (L1s) become transcriptionally derepressed and activate a type-I interferon (IFN-I) response. The IFN-I response is a novel phenotype of late senescence and contributes to the maintenance of the senescence associated secretory phenotype (SASP). …”
Publicado 2019
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772por Liao, Yuan, Goraya, Mohsan Ullah, Yuan, Xu, Zhang, Baoge, Chiu, Shih-Hsin, Chen, Ji-Long“…Interferons (IFNs) play crucial roles in host defense against viral infections by inducing the expression of numerous IFN-stimulated genes (ISGs) that can activate host antiviral immunity. …”
Publicado 2019
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773“…Type I interferon (IFN-I) is induced during innate immune response and is required for initiating antiviral activity, growth inhibition, and immunomodulation. …”
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774“…SLE is characterised by an activation of the interferon (IFN) system, which leads to an increased expression of IFN-regulated genes. …”
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775por Zeng, Jing, Meng, Xinyu, Zhou, Ping, Yin, Zhihua, Xie, Qinglian, Zou, Hong, Shen, Nan, Ye, Zhizhong, Tang, YuanjiaEnlace del recurso
Publicado 2019
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776por Helbig, K. J., Teh, M. Y., Crosse, K. M., Monson, E. A., Smith, M., Tran, E. N., Standish, A. J., Morona, R., Beard, M. R.“…The role of interferon and interferon stimulated genes (ISG) in limiting bacterial infection is controversial, and the role of individual ISGs in the control of the bacterial life-cycle is limited. …”
Publicado 2019
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777
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778“…One of the major causes of such a phenotype is the disruption of innate antiviral defenses associated with dysfunction of type 1 interferons (IFNs) that permits unlimited replication of viruses in cancer cells. …”
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779“…Previously, we have shown the formation of large protein aggregates along with activation of the interferon pathway leading to apoptosis in a cellular model of SCA17. …”
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780“…Infection of mice with Sindbis virus (SINV) provides a model for examining the role of the immune response to alphavirus infection of the central nervous system (CNS). Interferon-gamma (IFN-γ) is an important component of this response, and we show that SINV-infected differentiated neurons respond to IFN-γ in vitro by induction of antiviral genes and suppression of virus replication. …”
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