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  1. 761
    “…Replication of cardioviruses produces double stranded RNA that is detected by helicases in the RIG-I-like receptor family and leads to a signaling cascade to produce type I interferon. Like other viruses within Picornaviridae, however, cardioviruses have evolved several mechanisms to inhibit interferon production. …”
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    Innate Immune Detection of Cardioviruses and Viral Disruption of Interferon Signaling
  2. 762
    “…Type I interferon (IFN-I, including IFN-α and IFN-β) response has been implicated in eosinophilic inflammation, in addition to antiviral function. …”
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    Enhanced Interferon-β Response Contributes to Eosinophilic Chronic Rhinosinusitis
  3. 763
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    1760. Interferon Gamma Release Assay for Diagnosis of Lyme disease
  4. 764
    “…Interferons (IFNs) are key players in the tumor immune response and act by inducing the expression of IFN-stimulated genes (ISGs). …”
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    Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells()
  5. 765
    “…CONCLUSION: Overall, these findings demonstrate that a subset of SS patients (16%) harbor autoantibodies against GMCSF, interferon-γ, interferon-ω, and interferon-α. These data support the observation that high levels of interferon-α autoantibodies may attenuate disease symptoms in SS.…”
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    Clinical features of Sjögren’s syndrome patients with autoantibodies against interferons
  6. 766
    “…Type I interferon (IFN-I) is the first line of mammalian host defense against viral infection. …”
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    Suppression of Type I Interferon Signaling by Flavivirus NS5
  7. 767
    por Suprunenko, Tamara, Hofer, Markus J.
    Publicado 2019
    “…In particular, this model has clarified the central roles that type I interferons play in initiating and regulating host responses. …”
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    Complexities of Type I Interferon Biology: Lessons from LCMV
  8. 768
    “…In an attempt to better understand the pathogenesis of AMD, in this study, we evaluated the serum interferon (IFN) levels in patients with AMD and compared it with persons without AMD. …”
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    Evaluation of serum interferons in patients with age-related macular degeneration
  9. 769
    “…Interferon-alpha (IFN-α) is an important mediator of antiviral immune responses. …”
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    Interferon-alpha-Induced Changes in NODDI Predispose to the Development of Fatigue
  10. 770
    “…Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation and immune response by directly inducing anti-pathogen molecular countermeasures. …”
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    Differential Regulation of Type I and Type III Interferon Signaling
  11. 771
    “…Here we show that during cellular senescence LINE-1 elements (L1s) become transcriptionally derepressed and activate a type-I interferon (IFN-I) response. The IFN-I response is a novel phenotype of late senescence and contributes to the maintenance of the senescence associated secretory phenotype (SASP). …”
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    LINE-1 derepression in senescent cells triggers interferon and inflammaging
  12. 772
    “…Interferons (IFNs) play crucial roles in host defense against viral infections by inducing the expression of numerous IFN-stimulated genes (ISGs) that can activate host antiviral immunity. …”
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    Functional Involvement of Interferon-Inducible Transmembrane Proteins in Antiviral Immunity
  13. 773
    “…Type I interferon (IFN-I) is induced during innate immune response and is required for initiating antiviral activity, growth inhibition, and immunomodulation. …”
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    Fine-Tuning of Type I Interferon Response by STAT3
  14. 774
    por Rönnblom, Lars, Leonard, Dag
    Publicado 2019
    “…SLE is characterised by an activation of the interferon (IFN) system, which leads to an increased expression of IFN-regulated genes. …”
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    Interferon pathway in SLE: one key to unlocking the mystery of the disease
  15. 775
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    Interferon-α exacerbates neuropsychiatric phenotypes in lupus-prone mice
  16. 776
    “…The role of interferon and interferon stimulated genes (ISG) in limiting bacterial infection is controversial, and the role of individual ISGs in the control of the bacterial life-cycle is limited. …”
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    The interferon stimulated gene viperin, restricts Shigella. flexneri in vitro
  17. 777
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    Iminosugars counteract the downregulation of the interferon γ receptor by dengue virus
  18. 778
    “…One of the major causes of such a phenotype is the disruption of innate antiviral defenses associated with dysfunction of type 1 interferons (IFNs) that permits unlimited replication of viruses in cancer cells. …”
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    Defects in interferon pathways as potential biomarkers of sensitivity to oncolytic viruses
  19. 779
    “…Previously, we have shown the formation of large protein aggregates along with activation of the interferon pathway leading to apoptosis in a cellular model of SCA17. …”
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    Interferon mediated neuroinflammation in polyglutamine disease is not caused by RNA toxicity
  20. 780
    “…Infection of mice with Sindbis virus (SINV) provides a model for examining the role of the immune response to alphavirus infection of the central nervous system (CNS). Interferon-gamma (IFN-γ) is an important component of this response, and we show that SINV-infected differentiated neurons respond to IFN-γ in vitro by induction of antiviral genes and suppression of virus replication. …”
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    Interferon-Gamma Modulation of the Local T Cell Response to Alphavirus Encephalomyelitis
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