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781por Van der Sluis, Renée M., Zerbato, Jennifer M., Rhodes, Jake W., Pascoe, Rachel D., Solomon, Ajantha, Kumar, Nitasha A., Dantanarayana, Ashanti I., Tennakoon, Surekha, Dufloo, Jérémy, McMahon, James, Chang, Judy J., Evans, Vanessa A., Hertzog, Paul J., Jakobsen, Martin R., Harman, Andrew N., Lewin, Sharon R., Cameron, Paul U.“…We demonstrate diverse effects of interferons on HIV latency with type I IFNα; inhibiting the establishment of latency but also reversing HIV latency once latency is established.…”
Publicado 2020
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782por Greenberg, Elyse Noelani, Marshall, Michaela Ellen, Jin, Suoqin, Venkatesh, Sanan, Dragan, Morgan, Tsoi, Lam C., Gudjonsson, Johann E., Nie, Qing, Takahashi, Joseph S., Andersen, BogiEnlace del recurso
Publicado 2020
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783por Andreeva, Alfia, Nikolaeva, Oksana, Altynbekov, Oleg, Galieva, Chulpan, Ilina, Kseniia“…AIM: The research aimed to study the effect of interferon (IFN)-based drugs on the behavior of immunological parameters in calves during the specific prevention of associative infections. …”
Publicado 2020
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784por Borden, Ernest C., Sen, Ganes C., Uze, Gilles, Silverman, Robert H., Ransohoff, Richard M., Foster, Graham R., Stark, George R.“…The family of interferon (IFN) proteins has now more than reached the potential envisioned by early discovering virologists: IFNs are not only antivirals with a spectrum of clinical effectiveness against both RNA and DNA viruses, but are also the prototypic biological response modifiers for oncology, and show effectiveness in suppressing manifestations of multiple sclerosis. …”
Publicado 2007
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785“…Type I interferons (IFNs) comprise of pro-inflammatory cytokines created, as well as sensed, by all nucleated cells with the main objective of blocking pathogens-driven infections. …”
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786“…The aim of this study was to quantify and compare interferon-γ (IFN-γ) concentrations in the serum of clinically normal cats infected with feline coronavirus (FCoV) with its concentration in the sera and effusions of cats with feline infectious peritonitis (FIP), a disease associated with infection with a mutated form of FCoV. …”
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787por Teijaro, J.R.“…Since Isaac's and Lindenmann's seminal experiments over 50 years ago demonstrating a soluble factor generated from heat killed virus-stimulated chicken embryos could inhibit live influenza virus replication, the term interferon has been synonymous with inhibition of virus replication. …”
Publicado 2016
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788por Omatsu, Tsutomu, Bak, Eun-Jung, Ishii, Yoshiyuki, Kyuwa, Shigeru, Tohya, Yukinobu, Akashi, Hiroomi, Yoshikawa, Yasuhiro“…Bats are considered to be natural reservoirs for several viruses of clinical importance, including rabies virus, Nipah virus, and Hendra virus. Type I interferons (IFNs) is an important part of the immune system in the defense against viral infection. …”
Publicado 2008
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789por Livonesi, Márcia Cristina, Moro de Sousa, Ricardo Luiz, Badra, Soraya Jabur, Figueiredo, Luiz Tadeu Moraes“…To achieve a therapeutical agent to prevent and/or treat these diseases we evaluated the antiviral action of Interferon-alpha (IFN-α) on these orthobunyaviruses. …”
Publicado 2007
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791“…For more than 20 years, hepatitis C patients have been treated with interferon-alpha (IFN-α). Current treatment usually consists of polyethylene glycol-conjugated IFN-α that is combined with ribavirin, but even the most advanced IFN-based therapies are still ineffective in eliminating the virus from a large proportion of individuals. …”
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793por An, Dong, Guo, Yongli, Bao, Jun, Luo, Xiuxin, Liu, Ying, Ma, Bo, Gao, Mingchun, Wang, Junwei“…Bovine interferon-omega3 (BoIFN-ω3) gene was amplified from bovine liver genomic DNA, which encodes a 195-amino acid protein containing a 23-amino acid signal peptide. …”
Publicado 2017
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794por Zhang, Yuxiang, Zhu, Mengyan, Li, Gairu, Liu, Jie, Zhai, Xiaofeng, Wang, Ruyi, Zhang, Junyan, Xing, Gang, Gu, Jinyan, Yan, Liping, Lei, Jing, Sun, Haifeng, Shi, Zhiyu, Liu, Fei, Hu, Boli, Su, Shuo, Zhou, Jiyong“…Stimulator of interferon gene (STING) plays an important role in the cyclic GMP-AMP synthase (cGAS)-mediated activation of type I IFN responses. …”
Publicado 2017
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795por Sen, G.“…Antiviral actions of the interferon-inducible IFIT proteins Ganes Sen, Volker Fensterl, Jamie Wetzel The ISG56/IFIT genes are a multi-member family of interferon-inducible genes; there are four members in human and three in mouse. …”
Publicado 2012
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796por Markus, Mordstein, Eva, Neugebauer, Vanessa, Ditt, Birthe, Jessen, Toni, Rieger, Stephan, Günther, Thorsten, Wolff, Kevin, Klucher, Georg, Kochs, Stephan, Ehl, Thomas, Michiels, Christian, Drosten, Peter, StaeheliEnlace del recurso
Publicado 2009
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797“…Interferon was induced in two groups of swine lymphocyte antigen (SLA)-defined miniature pigs with polyinosinic: polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose. …”
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798“…Natural killer (NK) cell activity in the peripheral blood lymphocytes (PBL) of newborn piglets, normally negligible, was stimulated by in vitro treatment with porcine type I interferon (IFN), and the NK activity of PBL from weaned piglets was augmented by the same treatment. …”
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799“…The effect of liposome-encapsulation on the immunomodulating and antiviral activities of interferon-γ (IFN-γ) was evaluated in this study. The immunomodulating activity was measured by increases in phagocytic activity and in nitric oxide production by peritoneal macrophages from mice treated with both free and LIP-IFN-γ (4000 U/mouse, intraperitoneal injection). …”
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800por Prokunina-Olsson, Ludmila, Alphonse, Noémie, Dickenson, Ruth E., Durbin, Joan E., Glenn, Jeffrey S., Hartmann, Rune, Kotenko, Sergei V., Lazear, Helen M., O’Brien, Thomas R., Odendall, Charlotte, Onabajo, Olusegun O., Piontkivska, Helen, Santer, Deanna M., Reich, Nancy C., Wack, Andreas, Zanoni, IvanEnlace del recurso
Publicado 2020
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