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801“…Clinical investigations in patients with COVID-19 has shown a strong upregulation of cytokine and interferon production in SARS-CoV2- induced pneumonia, with an associated cytokine storm syndrome. …”
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802por Kuriyama, Yuko, Shimizu, Akira, Kanai, Saki, Oikawa, Daisuke, Tokunaga, Fuminori, Tsukagoshi, Hiroyuki, Ishikawa, OsamuEnlace del recurso
Publicado 2020
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803“…Here, we assess the possibility of using interferon‐lambda (IFNλ), a third type of interferon sharing low homology with type I IFNs and IL‐10, for treating COVID‐19 patients. …”
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804“…Down syndrome (DS), also known as trisomy 21 (T21), is associated with interferon (IFN) hypersensitivity, as well as predilections for Alzheimer's dementia (AD) and various autoimmune diseases. …”
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805por Kuroda, Makoto, Halfmann, Peter J., Hill-Batorski, Lindsay, Ozawa, Makoto, Lopes, Tiago J. S., Neumann, Gabriele, Schoggins, John W., Rice, Charles M., Kawaoka, Yoshihiro“…Here, we screen a library of nearly 400 interferon-stimulated genes (ISGs) against a biologically contained Ebola virus and identify several ISGs not previously known to affect Ebola virus infection. …”
Publicado 2020
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806por Malekzadeh, Masoud Mohammad, Alizadeh, Reza, Aghsaeifard, Ziba, Sahraian, Mohammad Ali“…A 43‐year‐old man who was treated with interferon‐beta for multiple sclerosis was presented with hypertension, headache, nausea/vomiting, blurred vision, and renal dysfunction. …”
Publicado 2020
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807“…Previous studies using rodents suggest that adult-born neurons are involved in memory and cognition tasks and mood regulation. Interferon-alpha (IFNα), a proinflammatory cytokine used for the treatment of chronic viral hepatitis and malignancies, frequently causes depressive symptoms in patients and animals, including non-human primates. …”
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808“…Recent reports that FAT10 downregulates type I interferon production while it upregulates IFN-γ pose mechanistic questions on how FAT10 differentially regulates interferon induction. …”
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809“…The interferon (IFN) system is one of the first lines of defense activated against invading viral pathogens. …”
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810por Tao, Lili, Lemoff, Andrew, Wang, Guoxun, Zarek, Christina, Lowe, Alexandria, Yan, Nan, Reese, Tiffany A“…We further demonstrated that ROS suppressed the type I interferon response by oxidizing Cysteine 147 on murine stimulator of interferon genes (STING), an ER-associated protein that mediates interferon response after cytoplasmic DNA sensing. …”
Publicado 2020
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811por Xia, Hongjie, Cao, Zengguo, Xie, Xuping, Zhang, Xianwen, Chen, John Yun-Chung, Wang, Hualei, Menachery, Vineet D., Rajsbaum, Ricardo, Shi, Pei-Yong“…Here, we use unbiased screening to identify SARS-CoV-2 proteins that antagonize type I interferon (IFN-I) response. We found three proteins that antagonize IFN-I production via distinct mechanisms: nonstructural protein 6 (nsp6) binds TANK binding kinase 1 (TBK1) to suppress interferon regulatory factor 3 (IRF3) phosphorylation, nsp13 binds and blocks TBK1 phosphorylation, and open reading frame 6 (ORF6) binds importin Karyopherin α 2 (KPNA2) to inhibit IRF3 nuclear translocation. …”
Publicado 2020
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812por Schreiber, Gideon“…Type I interferons (IFN-I) were first discovered over 60 years ago in a classical experiment by Isaacs and Lindenman, who showed that IFN-Is possess antiviral activity. …”
Publicado 2020
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813“…Respiratory syncytial virus (RSV) pneumonia is a leading cause of hospitalization and mortality among neonates worldwide, and there are currently no specific clinical treatments for RSV infection. Interferons (IFNs) possess broad-spectrum antiviral properties, and the present study aimed to evaluate the efficacy and safety of IFN-α1b for the treatment of neonatal RSV pneumonia. …”
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814por Zhou, Qiong, Chen, Virginia, Shannon, Casey P., Wei, Xiao-Shan, Xiang, Xuan, Wang, Xu, Wang, Zi-Hao, Tebbutt, Scott J., Kollmann, Tobias R., Fish, Eleanor N.Enlace del recurso
Publicado 2020
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815por Bagheri, Ashkan, Moezzi, Seyed Mohammad Iman, Mosaddeghi, Pouria, Nadimi Parashkouhi, Sadra, Fazel Hoseini, Seyed Mostafa, Badakhshan, Fatemeh, Negahdaripour, Manica“…On the other hand, induction of type I interferons are found to play an important role in the generation of immune responses against SARS-CoV-2. …”
Publicado 2021
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816por Fan, Ziqi, Zhao, Shuai, Zhu, Yueli, Li, Zheyu, Liu, Zhirong, Yan, Yaping, Tian, Jun, Chen, Yanxing, Zhang, Baorong“…BACKGROUND: Activated microglia play a vital role in neuroinflammation in the central nervous system (CNS), which is associated with the pathogenesis and the progression of neurological diseases. Interferon regulatory factor 5 (IRF5) has been well established participating in inflammatory responses and is highly expressed in M1 macrophage in the periphery, the role of which in the CNS remains elusive. …”
Publicado 2020
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817por Zhou, Quan D., Chi, Xun, Lee, Min Sub, Hsieh, Wei Yuan, Mkrtchyan, Jonathan J., Feng, An-Chieh, He, Cuiwen, York, Autumn G, Bui, Viet L., Kronenberger, Eliza B., Ferrari, Alessandra, Xiao, Xu, Daly, Allison E., Tarling, Elizabeth J., Damoiseaux, Robert, Scumpia, Philip O., Smale, Stephen T., Williams, Kevin J., Tontonoz, Peter, Bensinger, Steven J.“…Here, we report that interferon (IFN) signals convey resistance to CDC-induced pores on macrophages and neutrophils. …”
Publicado 2020
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818Potentials of Interferons and Hydroxychloroquine for the Prophylaxis and Early Treatment of COVID-19“…Compared to mild cases, severe cases of the COVID-19 have decreased interferon (IFN) α, β, λ production. Type I (IFN α/β) and III IFNs (λ) work coordinately to induce inhibition of viral reproduction through the stimulation of interferon stimulated genes (ISGs). …”
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819“…The aim of this review is to evaluate the role of type I interferons, a family of antiviral cytokines with key roles in the regulation of both obesity and cancer, highlighting how the dysregulation of the interferon system can differently affect these pathological conditions. …”
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