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  1. 841
    “…Our results further suggest that discrepancies between mouse and human susceptibility may be due to differences in interferon signaling.…”
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    Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis
  2. 842
    “…Interferon (IFN)-γ-inducible chemokines in the CXCR3/ligand axis are involved in cell-mediated immunity and play a significant role in the progression of cancer. …”
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    Interferon-γ-Inducible Chemokines as Prognostic Markers for Lung Cancer
  3. 843
    “…Being derived (or evolved) from ancient retroviruses, both HIV and LINE-1 replicate through a process termed reverse transcription, activate endogenous DNA and RNA sensors, trigger innate immune activation to promote interferon (IFN) expression, and are suppressed by protein products of interferon-stimulated genes (ISGs). …”
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    The Interplay Among HIV, LINE-1, and the Interferon Signaling System
  4. 844
    “…Establishment of the interferon (IFN)-mediated antiviral state provides a crucial initial line of defense against viral infection. …”
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    Discovery of Genes that Modulate Flavivirus Replication in an Interferon-Dependent Manner
  5. 845
    “…Interferons (IFNs) are among the first vertebrate immune pathways activated upon viral infection and are crucial for control of viral replication and dissemination, especially at mucosal surfaces as key locations for host exposure to pathogens. …”
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    Differential roles of interferons in innate responses to mucosal viral infections
  6. 846
    “…Understanding how each class of interferons controls B cell responses in SLE is necessary for developing optimized B cell- and interferon-targeted therapeutics. …”
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    Regulation of B Cell Responses in SLE by Three Classes of Interferons
  7. 847
    “…Early diagnosis and treatment are essential to control the TB epidemic. Interferon-gamma (IFN-γ) is a cytokine that plays a part in the body’s immune response when fighting infection. …”
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    Recent advances in the detection of interferon-gamma as a TB biomarker
  8. 848
    “…PURPOSE: The aim of this study was to evaluate the efficacy of topical interferon (IFN) therapy in pseudophakic cystoid macular edema (P-CME). …”
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    Topical interferon – A novel treatment for pseudophakic macular edema
  9. 849
    “…We recognized an opportunity for interferon-based immunomodulation in certain situations on this population at high risk for invasive bacterial infections. …”
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    1012. Neutrophil Function Enhanced by Recombinant Interferon-Gamma in Newborns
  10. 850
    “…Interferon lambda (IFNλ) signaling is a promising therapeutic target against viral infection in murine models, yet little is known about its molecular regulation and its cognate receptor, interferon lambda receptor 1 (IFNLR1) in human lung. …”
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    Interferon Lambda Signaling in Macrophages Is Necessary for the Antiviral Response to Influenza
  11. 851
    “…Host factors that influence Congenital Zika Syndrome (CZS) outcome remain elusive. Interferons have been reported as the main antiviral factor in Zika and other flavivirus infections. …”
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    Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1
  12. 852
    “…While studying the impact of NELL2 silencing on Ewing sarcoma, we found that suppression of NELL2 signaling induces the expression of endogenous retroviruses (ERVs) and LINE-1 retrotransposons, an interferon response, and growth arrest. We determined that a histone methyltransferase, EZH2, is the critical downstream target of NELL2 signaling in suppressing ERVs, LINE-1, an interferon response, and growth arrest. …”
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    EZH2 suppresses endogenous retroviruses and an interferon response in cancers
  13. 853
    por Zhang, Rui, Tang, Jun
    Publicado 2021
    “…Type I interferon (IFN-I) mediated innate immunity serves as the first line of host defense against viral infection, ranging from IFN-I production upon viral detection, IFN-I triggered signaling pathway that induces antiviral gene transcription the antiviral effects of IFN-I induced gene products. …”
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    Evasion of I Interferon-Mediated Innate Immunity by Pseudorabies Virus
  14. 854
    “…This study evaluated the role of interferons in the induction of rapid degradation of DRiPs to modulate the repertoire of DRiP-derived MHC peptides. …”
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    The Effect of Interferons on Presentation of Defective Ribosomal Products as HLA Peptides
  15. 855
    “…Far from attaining the ultimate treatment goal, hepatitis B virus (HBV) infection eradication, the two current therapeutic options aim to prevent progression to end-stage liver disease, maintaining long-term suppression of HBV replication. Pegylated interferon-α (PEG-INFα) is often poorly tolerated and disregarded considering the orally administered nucleos(t)ide analogues. …”
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    Pegylated Interferon Alpha for Chronic Hepatitis B Virus Infection
  16. 856
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    Introduction to the special issue on interferon responses: From cells to systems
  17. 857
    por Lee, Jeong Seok, Shin, Eui-Cheol
    Publicado 2020
    “…Despite early reports to the contrary, there is increasing evidence that patients with severe COVID-19 have a robust type I interferon response, which contrasts with the delayed, possibly suppressed, interferon response seen early in infection. …”
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    The type I interferon response in COVID-19: implications for treatment
  18. 858
    “…Engagement of macrophages in innate immune responses is directed by type I and type II interferons (IFN-I and IFN-γ, respectively). IFN triggers drastic changes in cellular transcriptomes, executed by JAK-STAT signal transduction and the transcriptional control of interferon-stimulated genes (ISG) by STAT transcription factors. …”
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    Interferons reshape the 3D conformation and accessibility of macrophage chromatin
  19. 859
    “…There is far more evidence that interferon can exacerbate migraines. We report a case where remission of severe comorbid migraine attacks happened with the start of interferon β1a (Merck, Netherlands) immunomodulation therapy. …”
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    Migraine, interferon β1a and siponimod immunomodulator therapies
  20. 860
    “…Interferon (IFN) therapies are used to treat a variety of infections and diseases and could be used to treat SARS-CoV-2. …”
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    Interferon Treatments for SARS-CoV-2: Challenges and Opportunities
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