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841por Burke, Thomas P, Engström, Patrik, Tran, Cuong J, Langohr, Ingeborg M, Glasner, Dustin R, Espinosa, Diego A, Harris, Eva, Welch, Matthew D“…Our results further suggest that discrepancies between mouse and human susceptibility may be due to differences in interferon signaling.…”
Publicado 2021
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842por Lee, Keu-Sung, Chung, Wou-Young, Park, Ji-Eun, Jung, Yun-Jung, Park, Joo-Hun, Sheen, Seung-Soo, Park, Kwang-Joo“…Interferon (IFN)-γ-inducible chemokines in the CXCR3/ligand axis are involved in cell-mediated immunity and play a significant role in the progression of cancer. …”
Publicado 2021
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843“…Being derived (or evolved) from ancient retroviruses, both HIV and LINE-1 replicate through a process termed reverse transcription, activate endogenous DNA and RNA sensors, trigger innate immune activation to promote interferon (IFN) expression, and are suppressed by protein products of interferon-stimulated genes (ISGs). …”
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844por Lesage, Sarah, Chazal, Maxime, Beauclair, Guillaume, Batalie, Damien, Cerboni, Silvia, Couderc, Elodie, Lescure, Aurianne, Del Nery, Elaine, Tangy, Frédéric, Martin, Annette, Manel, Nicolas, Jouvenet, Nolwenn“…Establishment of the interferon (IFN)-mediated antiviral state provides a crucial initial line of defense against viral infection. …”
Publicado 2022
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845“…Interferons (IFNs) are among the first vertebrate immune pathways activated upon viral infection and are crucial for control of viral replication and dissemination, especially at mucosal surfaces as key locations for host exposure to pathogens. …”
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846“…Understanding how each class of interferons controls B cell responses in SLE is necessary for developing optimized B cell- and interferon-targeted therapeutics. …”
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847“…Early diagnosis and treatment are essential to control the TB epidemic. Interferon-gamma (IFN-γ) is a cytokine that plays a part in the body’s immune response when fighting infection. …”
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848por Kawali, Ankush, Snehith, Ram, Singh, Vivek, Sanjay, Srinivasan, Mahendradas, Padmamalini, Shetty, Rohit“…PURPOSE: The aim of this study was to evaluate the efficacy of topical interferon (IFN) therapy in pseudophakic cystoid macular edema (P-CME). …”
Publicado 2021
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849“…We recognized an opportunity for interferon-based immunomodulation in certain situations on this population at high risk for invasive bacterial infections. …”
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850por Mallampalli, Rama K., Adair, Jessica, Elhance, Ajit, Farkas, Daniela, Chafin, Lexie, Long, Matthew E., De, Mithu, Mora, Ana L., Rojas, Mauricio, Peters, Victor, Bednash, Joseph S., Tsai, MuChun, Londino, James D.“…Interferon lambda (IFNλ) signaling is a promising therapeutic target against viral infection in murine models, yet little is known about its molecular regulation and its cognate receptor, interferon lambda receptor 1 (IFNLR1) in human lung. …”
Publicado 2021
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851por Azamor, Tamiris, Cunha, Daniela Prado, da Silva, Andréa Marques Vieira, Bezerra, Ohanna Cavalcanti de Lima, Ribeiro-Alves, Marcelo, Calvo, Thyago Leal, Kehdy, Fernanda de Souza Gomes, Manta, Fernanda Saloum de Neves, Pinto, Thiago Gomes de Toledo, Ferreira, Laís Pereira, Portari, Elyzabeth Avvad, Guida, Letícia da Cunha, Gomes, Leonardo, Moreira, Maria Elisabeth Lopes, de Carvalho, Elizeu Fagundes, Cardoso, Cynthia Chester, Muller, Marcelo, Ano Bom, Ana Paula Dinis, Neves, Patrícia Cristina da Costa, Vasconcelos, Zilton, Moraes, Milton Ozório“…Host factors that influence Congenital Zika Syndrome (CZS) outcome remain elusive. Interferons have been reported as the main antiviral factor in Zika and other flavivirus infections. …”
Publicado 2021
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852“…While studying the impact of NELL2 silencing on Ewing sarcoma, we found that suppression of NELL2 signaling induces the expression of endogenous retroviruses (ERVs) and LINE-1 retrotransposons, an interferon response, and growth arrest. We determined that a histone methyltransferase, EZH2, is the critical downstream target of NELL2 signaling in suppressing ERVs, LINE-1, an interferon response, and growth arrest. …”
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853“…Type I interferon (IFN-I) mediated innate immunity serves as the first line of host defense against viral infection, ranging from IFN-I production upon viral detection, IFN-I triggered signaling pathway that induces antiviral gene transcription the antiviral effects of IFN-I induced gene products. …”
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854“…This study evaluated the role of interferons in the induction of rapid degradation of DRiPs to modulate the repertoire of DRiP-derived MHC peptides. …”
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855por Vasconcelos, Joana, Domingos, João, Bastos, Lia, Baptista, Teresa, Mansinho, Kamal“…Far from attaining the ultimate treatment goal, hepatitis B virus (HBV) infection eradication, the two current therapeutic options aim to prevent progression to end-stage liver disease, maintaining long-term suppression of HBV replication. Pegylated interferon-α (PEG-INFα) is often poorly tolerated and disregarded considering the orally administered nucleos(t)ide analogues. …”
Publicado 2022
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856
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857“…Despite early reports to the contrary, there is increasing evidence that patients with severe COVID-19 have a robust type I interferon response, which contrasts with the delayed, possibly suppressed, interferon response seen early in infection. …”
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858por Platanitis, Ekaterini, Gruener, Stephan, Ravi Sundar Jose Geetha, Aarathy, Boccuni, Laura, Vogt, Alexander, Novatchkova, Maria, Sommer, Andreas, Barozzi, Iros, Müller, Mathias, Decker, Thomas“…Engagement of macrophages in innate immune responses is directed by type I and type II interferons (IFN-I and IFN-γ, respectively). IFN triggers drastic changes in cellular transcriptomes, executed by JAK-STAT signal transduction and the transcriptional control of interferon-stimulated genes (ISG) by STAT transcription factors. …”
Publicado 2022
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859“…There is far more evidence that interferon can exacerbate migraines. We report a case where remission of severe comorbid migraine attacks happened with the start of interferon β1a (Merck, Netherlands) immunomodulation therapy. …”
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860por Jhuti, Diya, Rawat, Angeli, Guo, Christina M., Wilson, Lindsay A., Mills, Edward J., Forrest, Jamie I.“…Interferon (IFN) therapies are used to treat a variety of infections and diseases and could be used to treat SARS-CoV-2. …”
Publicado 2022
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