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861por Chen, Xi, Zou, Zhiwei, Wang, Qianli, Gao, Wenwen, Zeng, Sisi, Ye, Shuangyan, Xu, Pengfei, Huang, Mengqiu, Li, Keyi, Chen, Jianping, Zhong, Zhuo, Zhang, Qianbing, Hao, Bingtao, Liu, QiuzhenEnlace del recurso
Publicado 2022
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862por Khorramdelazad, Hossein, Kazemi, Mohammad Hossein, Azimi, Maryam, Aghamajidi, Azin, Mehrabadi, Ali Zarezadeh, Shahba, Faezeh, Aghamohammadi, Nazanin, Falak, Reza, Faraji, Fatemeh, Jafari, Reza“…No specific treatment is currently available for COVID-19, and the discovery of effective therapeutics requires understanding the effective immunologic and immunopathologic mechanisms behind this infection. Type-I interferons (IFN-Is), as the critical elements of the immediate immune response against viral infections, can inhibit the replication and spread of the viruses. …”
Publicado 2022
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863por Schilling, Erik, Wald, Maria Elisabeth, Schulz, Juliane, Werner, Lina Emilia, Claus, Claudia“…Interferons (IFNs) are an essential part of innate immunity and contribute to adaptive immune responses. …”
Publicado 2022
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864por Miller, Derek, Romero, Roberto, Kacerovsky, Marian, Musilova, Ivana, Galaz, Jose, Garcia-Flores, Valeria, Xu, Yi, Pusod, Errile, Demery-Poulos, Catherine, Gutierrez-Contreras, Pedro, Liu, Tzu Ning, Jung, Eunjung, Theis, Kevin R., Coleman, Lanetta A., Gomez-Lopez, Nardhy“…Interferon epsilon (IFNe) is a recently described cytokine that is constitutively expressed in the female reproductive tract. …”
Publicado 2022
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865“…Stimulator of interferon gene (STING), an intracellular receptor in the endoplasmic reticulum, could induce the production of cytokines such as type I interferon (IFN) by activating the cGAS-STING signal pathway. …”
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867por Guo, Kejun, Barrett, Bradley S., Morrison, James H., Mickens, Kaylee L., Vladar, Eszter K., Hasenkrug, Kim J., Poeschla, Eric M., Santiago, Mario L.“…While Spike mutations that enhance virus infectivity or neutralizing antibody evasion may drive the emergence of these novel variants, studies documenting a critical role for interferon responses in the early control of SARS-CoV-2 infection, combined with the presence of viral genes that limit these responses, suggest that interferons may also influence SARS-CoV-2 evolution. …”
Publicado 2022
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868por Thoidingjam, Leishemba K., Blouin, Cédric M., Gaillet, Christine, Brion, Aurélien, Solier, Stéphanie, Niyomchon, Supaporn, El Marjou, Ahmed, Mouasni, Sara, Sepulveda, Fernando E., de Saint Basile, Geneviève, Lamaze, Christophe, Rodriguez, Raphaël“…Interferons (IFN) are cytokines which, upon binding to cell surface receptors, trigger a series of downstream biochemical events including Janus Kinase (JAK) activation, phosphorylation of Signal Transducer and Activator of Transcription protein (STAT), translocation of pSTAT to the nucleus and transcriptional activation. …”
Publicado 2022
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869por Marques-da-Silva, Camila, Peissig, Kristen, Walker, Michael P., Shiau, Justine, Bowers, Carson, Kyle, Dennis E., Vijay, Rahul, Lindner, Scott E., Kurup, Samarchith P.“…Plasmodium parasites that cause malaria undergo obligatory development and replication in hepatocytes before infecting red blood cells and initiating clinical disease. While type I interferons (IFNs) are known to facilitate innate immune control to Plasmodium in the liver, how they do so has remained unresolved, precluding the manipulation of such responses to combat malaria. …”
Publicado 2022
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870“…INTRODUCTION: Interferon (IFN)-β is known as an environmental trigger for the occurrence of autoimmune thyroid disease (AITD). …”
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871por Sebastian, Agata, Madej, Marta, Gajdanowicz, Paweł, Sebastian, Maciej, Łuczak, Anna, Zemelka-Wiącek, Magdalena, Jutel, Marek, Wiland, Piotr“…Many cytokines take part in this process, including interferon. The study aimed to quantify certain cytokines involved in the pathomechanism of primary Sjögren syndrome (IL2, IL5, IL6, IL10, IL13, TNFα, IFNγ) and determine their common clinical correlation. …”
Publicado 2022
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872por Guild, Allison, Fritch, Jordan, Patel, Sachit, Reinhardt, Adam, Acquazzino, Melissa“…Trisomy 21 autoimmunity and HLH are both thought to be driven by interferon gamma. Targeting therapy toward interferon signaling in both HLH and autoimmunity in trisomy 21 may have potential therapeutic benefits. …”
Publicado 2022
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875por Schwerk, Johannes, Kemper, Lucas, Bussey, Kendra A., Lienenklaus, Stefan, Weiss, Siegfried, Čičin-Šain, Luka, Kröger, Andrea, Kalinke, Ulrich, Collins, Christopher M., Speck, Samuel H., Messerle, Martin, Wirth, Dagmar, Brinkmann, Melanie M., Hauser, Hansjörg, Köster, Mario“…We investigated the interplay between the type I interferon (IFN)-mediated innate immune response and MHV-68 latency using sensitive bioluminescent reporter mice. …”
Publicado 2022
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878por Bosco, Anthony“…Decades of research has focused on the role of type I interferons in antiviral immunity and ensuing airway diseases, however, recent findings have highlighted several novel aspects of the interferon response that merit further investigation. …”
Publicado 2023
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879por Lai, Jing Yung, Ho, Jian Xiang, Kow, Audrey Siew Foong, Liang, Gengfan, Tham, Chau Ling, Ho, Yu-Cheng, Lee, Ming Tatt“…Interferons (IFNs) are important in controlling the innate immune response to viral infections. …”
Publicado 2023
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880“…Here we show that mitogen-induced expression of interferon (IFN) regulatory factor 4 (IRF-4), a lymphoid-specific member of the IFN family of transcription factors, is Rel dependent. …”
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