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901por Coenen, Martin, Hinze, Annette Viktoria, Mengel, Martin, Fuhrmann, Christine, Lüdenbach, Bastian, Zimmermann, Julian, Dykstra, Verena, Fimmers, Rolf, Viviani, Roberto, Stingl, Julia, Holdenrieder, Stefan, Müller, Marcus, Hartmann, Gunther, Coch, Christoph“…Three different cohorts (20 healthy volunteers, 20 patients with RRMS and ongoing interferon-beta treatment and 10 patients starting on interferon-beta) will receive standard interferon-beta-1a therapy for nine days. …”
Publicado 2015
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902por Zhou, Hao, Chen, Shun, Zhou, Qin, Wei, Yunan, Wang, Mingshu, Jia, Renyong, Zhu, Dekang, Liu, Mafeng, Liu, Fei, Yang, Qiao, Wu, Ying, Sun, Kunfeng, Chen, Xiaoyue, Cheng, Anchun“…Interferons are a group of antiviral cytokines acting as the first line of defense in the antiviral immunity. …”
Publicado 2016
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903por Feng, Linyuan, Sheng, Jingxue, Vu, Gia-Phong, Liu, Yujun, Foo, Chingman, Wu, Songbin, Trang, Phong, Paliza-Carre, Marco, Ran, Yanhong, Yang, Xiaoping, Sun, Xu, Deng, Zemin, Zhou, Tianhong, Lu, Sangwei, Li, Hongjian, Liu, Fenyong“…Interferon-γ (IFN-γ) represents one of the most important innate immunity responses in a host to combat infections of many human viruses including human herpesviruses. …”
Publicado 2018
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904por Oldford, Sharon A., Salsman, Suzanne P., Portales‐Cervantes, Liliana, Alyazidi, Raidan, Anderson, Robert, Haidl, Ian D, Marshall, Jean S.“…Found in substantial numbers at sites of potential infection they are increased at sites of angiogenesis and can be pivotal for the sensing and clearance of a variety of pathogens. Interferons (IFNs) are cytokines that are critical for host defence against intracellular pathogens. …”
Publicado 2017
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905por Cohan, Stanley, Smoot, Kyle, Kresa-Reahl, Kiren, Garland, Robert, Yeh, Wei-Shi, Wu, Ning, Watson, Crystal“…INTRODUCTION: This study was designed to assess real-world outcomes of patients with multiple sclerosis (MS) who were stable on interferon (IFN) beta therapy in the year prior to switching to another IFN beta therapy versus those who continued on the initial treatment. …”
Publicado 2018
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906por ter Horst, Ellis N., Krijnen, Paul A. J., Hakimzadeh, Nazanin, Robbers, Lourens F. H. J., Hirsch, Alexander, Nijveldt, Robin, Lommerse, Ingrid, Fontijn, Ruud D., Meinster, Elisa, Delewi, Ronak, van Royen, Niels, Zijlstra, Felix, van Rossum, Albert C., van der Schoot, C. Ellen, van der Pouw Kraan, Tineke C. T. M., Horrevoets, Anton J., van der Laan, Anja M., Niessen, Hans W. M., Piek, Jan J.“…Transcriptional profiling and pathway analysis revealed that patients with a decreased LV EDVi showed an induction of type I interferon (IFN) signalling (type I IFN pathway: P value < 0.001; false discovery rate < 0.001). …”
Publicado 2018
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907“…Previous reports suggest that type I and type II Interferon can co-operatively inhibit some virus replication, e.g. …”
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908por Butler, Oisín, Heeg, Simone, Holl, Katsiaryna, Frenz, Ann-Kathrin, Wicklein, Eva-Maria, Rametta, Mark, Yeo, Sandy“…BACKGROUND: Both interferon beta-1b (IFN-β-1b) and interferon beta-1a (IFN-β-1a) are immunomodulators that require regular subcutaneous self-administration by patients with multiple sclerosis (MS). …”
Publicado 2021
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909por Boeren, Marlies, Van Breedam, Elise, Buyle-Huybrecht, Tamariche, Lebrun, Marielle, Meysman, Pieter, Sadzot-Delvaux, Catherine, Van Tendeloo, Viggo F., Mortier, Geert, Laukens, Kris, Ogunjimi, Benson, Ponsaerts, Peter, Delputte, Peter“…Using this model, we showed that hiPSC-neurons do not mount an effective interferon-mediated antiviral response following VZV infection. …”
Publicado 2022
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910“…Type I interferons (IFNs) are central mediators of anti-viral and anti-bacterial host defence. …”
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911“…Porcine interferon α (poIFN-α) is a crucial cytokine that can prevent and treat viral infections. …”
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912por Xu, Chuan, Wang, Annie, Ebraham, Laith, Sullivan, Liam, Tasker, Carley, Pizutelli, Vanessa, Couret, Jennifer, Hernandez, Cyril, Deb, Pratik Q., Fritzky, Luke, Subbian, Selvakumar, Gao, Nan, Lo, Yungtai, Salvatore, Mirella, Rivera, Amariliz, Lemenze, Alexander, Fitzgerald-Bocarsly, Patricia, Tyagi, Sanjay, Lu, Wuyuan, Beaulieu, Aimee, Chang, Theresa L.“…Interferon ε (IFNε) is a unique type I IFN that has been implicated in host defense against sexually transmitted infections (STIs). …”
Publicado 2023
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913por Panigrahi, Trailokyanath, D’Souza, Sharon, Suresh Babu, Vishnu, Dickman, Mor M, Nuijts, Rudy M M A, Sethu, Swaminathan, Shetty, Rohit“…PURPOSE: Dry eye disease (DED) is characterized by altered ocular surface proinflammatory and antiinflammatory factors. Interferons (IFNs) are a class of pleiotropic cytokines well known for their antimicrobial, inflammatory, and immunomodulatory roles. …”
Publicado 2023
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914por Nombel, Anais, Foray, Anne Perrine, Garnier, Lorna, Lombard, Christine, Hachulla, Eric, Bader-Meunier, Brigitte, Georgin-Lavialle, Sophie, Melki, Isabelle, Walzer, Thierry, Belot, Alexandre, Viel, Sebastien“…We report here the French experience on a type I interferon pathway assay that has been set up and used routinely since 2018 in Lyon, France.…”
Publicado 2023
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915por Ye, Qianyu, Wang, Jiali, Chen, Meijing, Nie, Weijian, Zhang, Huanxi, Su, Xiaojun, Ling, Liuting, Liu, Xiangjun, Liu, Longshan, Wang, Changxi, Gao, Yifang“…OBJECTIVES: We describe a new method, FlowSpot, to assess CMV-specific T-cell response by quantification of interferon-gamma (IFN-γ). CMV-specific, T-cell-released IFN-γ was captured by flow beads and measured via flow cytometry. …”
Publicado 2023
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916por Kurhade, Chaitanya, Kang, Soowon, Biering, Scott B., Hwang, Seungmin, Randall, Glenn“…We have shown that two evolutionarily conserved defense systems, autophagy and interferon (IFN), target viral RCs and inhibit viral replication collaboratively. …”
Publicado 2023
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917por Eldeen Bazid, Heba Allah Saad, Marae, Alaa H., Tayel, Nermin, Zaid, Shereen G., Mostafa, Mohammed I., Abd El Gayed, Eman Masoud“…In a single experimental research, virally infected mouse models showed elevated kisspeptin levels and low interferon levels. OBJECTIVE: The objective of the study was to evaluate the serum levels of kisspeptin and interferon (INF)-beta in GW patients. …”
Publicado 2023
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918por Cozzolino, Kira, Sanford, Lynn, Hunter, Samuel, Molison, Kayla, Erickson, Benjamin, Jones, Taylor, Ajit, Deepa, Galbraith, Matthew D., Espinosa, Joaquin M., Bentley, David L., Allen, Mary A., Dowell, Robin D., Taatjes, Dylan J.“…Hyperactive interferon (IFN) signaling is a hallmark of Down syndrome (DS), a condition caused by trisomy 21 (T21); strategies that normalize IFN signaling could benefit this population. …”
Publicado 2023
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919por Engel, Job J., van der Made, Caspar I., Keur, Nick, Setiabudiawan, Todia, Röring, Rutger J., Damoraki, Georgia, Dijkstra, Helga, Lemmers, Heidi, Ioannou, Sofia, Poulakou, Garyfallia, van der Meer, Jos W. M., Giamarellos-Bourboulis, Evangelos J., Kumar, Vinod, van de Veerdonk, Frank L., Netea, Mihai G., Ziogas, Athanasios“…Dexamethasone treatment in COVID-19 patients resulted in down-regulation of genes related to type I and II interferon (IFN) signaling in whole blood immune cells. …”
Publicado 2023
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920por Anfossi, Renatto, Vivar, Raúl, Ayala, Pedro, González-Herrera, Fabiola, Espinoza-Pérez, Claudio, Osorio, José Miguel, Román-Torres, Mauricio, Bolívar, Samir, Díaz-Araya, Guillermo“…Introduction: Cardiac fibroblasts (CF) are crucial cells in damaged heart tissues, expressing TLR4, IFN-receptor and responding to lipopolysaccharide (LPS) and interferon-β (IFN-β) respectively. While CF interact with immune cells; however, their relationship with neutrophils remains understudied. …”
Publicado 2023
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