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941“…The production of an interferon-like substance by vaccinia virus is described. …”
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942“…Extracts of tissues of animals infected at birth with the M variant had measurable levels of interferon, reaching a peak on the 5th day after infection with the virus. …”
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943“…Because the biological and chemical characteristics of the viral inhibitor induced by helenine are similar to those of interferon, it is suggested that the antiviral effect of helenine may be mediated through the formation of interferon.…”
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944Publicado 1983“…The effect was observed in mice injected with antibody to interferon raised in three sheep, a goat, and a rabbit, but not with sheep antibody to "impurities" present in the mouse interferon preparations or with normal sheep or goat globulins. …”
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945Publicado 1983“…Antigen and mitogen-induced gamma interferon (gamma-IFN) production was studied in peripheral blood mononuclear cells from 34 leprosy patients. 17 of 18 lepromatous leprosy and borderline lepromatous patients (LL and BL) failed to release gamma-IFN in response to specific antigen (Mycobacterium leprae) and displayed reduced responses to mitogen (concanavalin A) stimulation. …”
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946Publicado 1984“…Murine peritoneal exudate cells (PEC) treated with murine recombinant interferon-gamma (IFN-gamma) (greater than 99% estimated purity), or concanavalin A-stimulated spleen cell supernatants developed tumoricidal properties (macrophage activation factor [MAF] activity). …”
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947Publicado 1984“…Gamma-interferon (IFN-gamma) is the macrophage-activating factor (MAF) produced by normal murine splenic cells and the murine T cell hybridoma 24/G1 that induces nonspecific tumoricidal activity in macrophages. …”
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948
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949
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950
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951Publicado 1994“…Interferon gamma (IFN-gamma) interacts synergistically with bacterial lipopolysaccharide (LPS) to induce transcription of iNOS, the isoform of nitric oxide synthase whose activity is independent of elevated Ca2+ and exogenous calmodulin. …”
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952Publicado 1996“…Interferon (IFN) gamma induces replacements of the proteasomal subunits X and Y by LMP7 and LMP2, respectively, resulting in an alteration of the proteolytic specificity. …”
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953
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954por Tau, Gregory Z., von der Weid, Thierry, Lu, Binfeng, Cowan, Simone, Kvatyuk, Marina, Pernis, Alessandra, Cattoretti, Giorgio, Braunstein, Ned S., Coffman, Robert L., Rothman, Paul B.“…For example, Th2 cells express both chains of the interferon γ receptor (IFN-γR), whereas Th1 cells do not express the second chain of the IFN-γR (IFN-γR2) and are therefore unresponsive to IFN-γ. …”
Publicado 2000
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955por Sgarbanti, Marco, Borsetti, Alessandra, Moscufo, Nicola, Bellocchi, Maria C., Ridolfi, Barbara, Nappi, Filomena, Marsili, Giulia, Marziali, Giovanna, Coccia, Eliana M., Ensoli, Barbara, Battistini, Angela“…A sequence in the 5′ HIV-1 LTR, containing a binding site for transcription factors of the interferon regulatory factors (IRF) family has been suggested to be critical for HIV-1 transcription and replication. …”
Publicado 2002
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956por Beers, Courtney, Honey, Karen, Fink, Susan, Forbush, Katherine, Rudensky, Alexander“…We observe that catL plays no significant role in Ii cleavage in interferon (IFN)-γ–stimulated Mφs. In addition, our studies show that the level of catL activity is significantly decreased in Mφs cultured in the presence of IFN-γ whereas catS activity increases. …”
Publicado 2003
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957“…In these studies, we have investigated whether Fas-mediated apoptosis can be regulated by interferon regulatory factor 4 (IRF-4), a lymphoid-restricted member of the IRF family of transcription factors. …”
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958por Gao, Yunfei, Yang, Wancai, Pan, Meng, Scully, Eileen, Girardi, Michael, Augenlicht, Leonard H., Craft, Joe, Yin, Zhinan“…Interferon (IFN)-γ is necessary for tumor immunity, however, its initial cellular source is unknown. …”
Publicado 2003
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959por Gabriele, Lucia, Phung, Jan, Fukumoto, Jon, Segal, David, Wang, I-Ming, Giannakakou, Paraskevi, Giese, Nathalie A., Ozato, Keiko, Morse, Herbert C.“…Mice with a null mutation of the gene encoding interferon consensus sequence–binding protein (ICSBP) develop a disease with marked expansion of granulocytes and macrophages that frequently progresses to a fatal blast crisis, thus resembling human chronic myelogenous leukemia (CML). …”
Publicado 1999
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960por Khabar, Khalid S.A., Al-Zoghaibi, Fahad, Al-Ahdal, Mohammed N., Murayama, Tsugiya, Dhalla, Mohammed, Mukaida, Naofumi, Taha, Mohammed, Al-Sedairy, Sultan T., Siddiqui, Yunus, Kessie, George, Matsushima, Kouji“…Interferon (IFN) exhibits a potent antiviral activity in vitro and plays a major role in the early defense against viruses. …”
Publicado 1997
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