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961“…Type I interferons α and β, naturally produced regulators of cell growth and differentiation, have been shown to inhibit IL-7–induced growth and survival of B cell precursors in vitro. …”
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962por Auerbuch, Victoria, Brockstedt, Dirk G., Meyer-Morse, Nicole, O'Riordan, Mary, Portnoy, Daniel A.“…Listeria monocytogenes is a facultative intracellular pathogen that induces a cytosolic signaling cascade resulting in expression of interferon (IFN)-β. Although type I IFNs are critical in viral defense, their role in immunity to bacterial pathogens is much less clear. …”
Publicado 2004
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963por O'Connell, Ryan M., Saha, Supriya K., Vaidya, Sagar A., Bruhn, Kevin W., Miranda, Gustavo A., Zarnegar, Brian, Perry, Andrea K., Nguyen, Bidong O., Lane, Timothy F., Taniguchi, Tadatsugu, Miller, Jeff F., Cheng, Genhong“…Numerous bacterial products such as lipopolysaccharide potently induce type I interferons (IFNs); however, the contribution of this innate response to host defense against bacterial infection remains unclear. …”
Publicado 2004
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964“…Three lines of evidence suggested that APC-dependent stimulation of T cells by CpG DNA was mediated by type I interferons (IFN-I). First, T cell activation by CpG DNA was undetectable in IFN-IR(−/−) mice. …”
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965por Diacovo, Thomas G., Blasius, Amanda L., Mak, Tak W., Cella, Marina, Colonna, Marco“…Natural interferon-producing cells (IPCs) are found in peripheral lymph nodes (PLNs), where they support NK cell, T cell, and B cell responses to pathogens. …”
Publicado 2005
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966por Nestle, Frank O., Conrad, Curdin, Tun-Kyi, Adrian, Homey, Bernhard, Gombert, Michael, Boyman, Onur, Burg, Günter, Liu, Yong-Jun, Gilliet, Michel“…We show that plasmacytoid predendritic cells (PDCs), the natural interferon (IFN)-α–producing cells, infiltrate the skin of psoriatic patients and become activated to produce IFN-α early during disease formation. …”
Publicado 2005
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967por Asselin-Paturel, Carine, Brizard, Géraldine, Chemin, Karine, Boonstra, Andre, O'Garra, Anne, Vicari, Alain, Trinchieri, Giorgio“…In this study we show that, in vivo, cDCs and pDCs are equally activated by TLR4, -7, and -9 ligands. Type I interferon (IFN) was important for pDC activation in vivo in response to all three TLR ligands, whereas cDCs required type I IFN signaling only for TLR9- and partially for TLR7-mediated activation. …”
Publicado 2005
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968“…Preparations of NDV(uv)-induced L-cell interferon were labeled in vitro with (125)I and (3)H gas, or in vivo through incorporation of amino acids-(3)H during synthesis. …”
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969“…Recombinant human interferon alpha inhibits growth of a human colon cancer cell line, Colo 205. …”
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970“…Treatment of human cells with Type 1 interferons restricts HIV replication. Here we report that the tripartite motif protein TRIM22 is a key mediator. …”
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971por Halme, M, Knuuttila, A, Vehmas, T, Tammilehto, L, Mäntylä, M, Salo, J, Mattson, K“…Twenty six patients with pleural mesothelioma of UICC stage I–IV excluding M1 disease (46% of whom had stage I disease and 38% stage III disease) were treated intravenously with high dose MTX (3 g) and calcium folinate rescue three times at intervals of 2 weeks and three times at intervals of 3 weeks. Natural interferon (IFN)-α (3 MIU days 2–10) and recombinant IFN-γ 1b (50 μg m(−2) on days 2, 6 and 10) were injected subcutaneously after each MTX dose. …”
Publicado 1999
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972“…Preparations of murine recombinant interferon (Mu-rIFN)-alpha, -beta and -gamma were assessed for their influence on in vitro growth of mast cells from normal mouse spleen cells (Sp C). …”
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973“…Recombinant rat interferon γ stimulated the contractility of isolated rat ileum at doses of 4–12 units/ml. …”
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974
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975“…A 23-year-old woman with an alveolar soft-part sarcoma of her calf with pulmonary metastases unresponsive to chemotherapy is described. Interferon (IFN) alpha-2b induced an impressive tumour response still ongoing after IFN treatment had to be stopped because of a psychosis. …”
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976por Carthagena, Laetitia, Parise, Mélanie C, Ringeard, Mathieu, Chelbi-Alix, Mounira K, Hazan, Uriel, Nisole, Sébastien“…Although TRIM5α is constitutively expressed, its expression has been shown to be up-regulated by type I interferon (IFN). Among primates, a particular case exists in owl monkey cells, which express a fusion protein between TRIM5 and cyclophilin A, TRIMCyp, specifically interfering with HIV-1 infection. …”
Publicado 2008
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977por Bonville, Cynthia A, Percopo, Caroline M, Dyer, Kimberly D, Gao, Jiliang, Prussin, Calman, Foster, Barbara, Rosenberg, Helene F, Domachowske, Joseph B“…RESULTS: In this work, we demonstrate that CCL3-mediated neutrophil recruitment is coordinated by interferon-gamma (IFNγ). Neutrophil recruitment in response to PVM infection was diminished five-fold in IFNγ receptor gene-deleted mice, although neutrophils from IFNγR -/- mice expressed transcripts for the CCL3 receptor, CCR1 and responded functionally to CCL3 ex vivo. …”
Publicado 2009
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978
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979“…Factors associated with treatment failure include HCV genotype 1 infection, high serum HCV RNA levels, and advanced fibrosis. Consensus interferon (CIFN) is a synthetic type I interferon derived from a consensus sequence of the most common amino acids found in naturally occurring alpha interferon subtypes. …”
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980“…The 1990s ushered in an era of possibility with the approval of three interferon-beta (IFNβ) therapies for the treatment of MS. …”
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