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981“…Conventional interferons including interferon-α (IFN-α) are cytokines used for years in the treatment of solid tumors and hematological malignancies. …”
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982
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983por Waddell, Simon J., Popper, Stephen J., Rubins, Kathleen H., Griffiths, Michael J., Brown, Patrick O., Levin, Michael, Relman, David A.“…Interferons are key modulators of the immune system, and are central to the control of many diseases. …”
Publicado 2010
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984“…BACKGROUND: Studies of the host response to infection often require quantitative measurement of the antiviral type I interferons (IFN-α/β) in biological samples. The amount of IFN is either determined via its ability to suppress a sensitive indicator virus, by an IFN-responding reporter cell line, or by ELISA. …”
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985“…Virus recognition and induction of interferon (IFN) are critical components of the innate immune system. …”
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986por Arnaud, Noëlla, Dabo, Stéphanie, Maillard, Patrick, Budkowska, Agata, Kalliampakou, Katerina I., Mavromara, Penelope, Garcin, Dominique, Hugon, Jacques, Gatignol, Anne, Akazawa, Daisuke, Wakita, Takaji, Meurs, Eliane F.“…Hepatitis C virus is a poor inducer of interferon (IFN), although its structured viral RNA can bind the RNA helicase RIG-I, and activate the IFN-induction pathway. …”
Publicado 2010
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987“…The standard treatment for chronic HCV is combination therapy with pegylated interferon-α and ribavirin. Although pegylated interferon and ribavirin has been used against HCV for close to a decade, advances in therapy have centered on doses and treatment durations. …”
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988por Harley, Isaac T. W., Niewold, Timothy B., Stormont, Rebecca M., Kaufman, Kenneth M., Glenn, Stuart B., Franek, Beverly S., Kelly, Jennifer A., Kilpatrick, Jeffrey R., Hutchings, David, Divers, Jasmin, Bruner, Gail R., Edberg, Jeffrey C., McGwin, Gerald, Petri, Michelle A., Ramsey-Goldman, Rosalind, Reveille, John D., Vilá-Pérez, Luis M., Merrill, Joan T., Gilkeson, Gary S., Vyse, Timothy J., Alarcón-Riquelme, Marta E., Cho, Soo-Kyung, Jacob, Chaim O., Alarcón, Graciela S., Moser, Kathy L., Gaffney, Patrick M., Kimberly, Robert P., Bae, Sang-Cheol, Langefeld, Carl D., Harley, John B., Guthridge, Joel M., James, Judith A.“…Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by increased type I interferons (IFNs) and multiorgan inflammation frequently targeting the skin. …”
Publicado 2010
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989“…It is not known if the response to β-interferon is also different. AIM: To demonstrate the decrease in relapses with β-interferon in Indian patients with multiple sclerosis. …”
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990“…BACKGROUND: There has been little discussion about the importance of oral management and interferon (IFN) therapy, although management of the side effects of therapy for chronic hepatitis C has been documented. …”
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991por Cobelens, Pieter M, Tiebosch, Ivo ACW, Dijkhuizen, Rick M, van der Meide, Peter H, Zwartbol, René, Heijnen, Cobi J, Kesecioglu, Jozef, van den Bergh, Walter M“…The objective of this study was to assess the immunomodulatory effects of interferon-β (IFN-β) on inflammatory mediators in the lung after experimental SAH. …”
Publicado 2010
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992por De Regge, Nick, Van Opdenbosch, Nina, Nauwynck, Hans J., Efstathiou, Stacey, Favoreel, Herman W.“…METHODOLOGY/PRINCIPAL FINDINGS: Here, using an in vitro model that enables a natural route of infection, we show that interferon alpha (IFNalpha) has the previously uncharacterized capacity to induce a quiescent HSV-1 and PRV infection in porcine TG neurons that shows strong similarity to in vivo latency. …”
Publicado 2010
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993por Schablon, Anja, Harling, Melanie, Diel, Roland, Ringshausen, Felix C., Torres Costa, Jose, Nienhaus, Albert“…So far, there is no consensus on how to define and interpret interferon-gamma release assays (IGRA) conversions and reversions, or how to deal with such results. …”
Publicado 2010
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994por Berry, A., Matthews, L., Jangani, M., Plumb, J., Farrow, S., Buchan, N., Wilson, P. A., Singh, D., Ray, D. W., Donn, R. P.“…A., Singh, D., Ray, D., W., Donn, R. P. Interferon-inducible factor 16 is a novel modulator of glucocorticoid action.…”
Publicado 2010
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995“…Bunyamwera virus NSs protein is involved in the inhibition of cellular transcription and the interferon (IFN) response, and it interacts with the Med8 component of Mediator. …”
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996“…However, data concerning conversion and reversion rates in serial testing of healthcare workers (HCWs) with an interferon-γ release assay are sparse. METHODS: Between February 2007 and September 2009, 670 HCWs in the University Hospital of Porto, Portugal were tested at least twice with QuantiFERON-TB(®) Gold In-Tube (QFT) for LTBI. …”
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997por Kobawala, Toral P., Patel, Girish H., Gajjar, Dhara R., Patel, Kamini N., Thakor, Premal B., Parekh, Urvi B., Patel, Kirti M., Shukla, Shilin N., Shah, Pankaj M.“…Serum interleukin-8 (IL-8) and interferon-alpha (IFN-α) levels have been estimated from a total of 88 individuals of which 19 were disease-free healthy individuals, and 69 were patients with thyroid diseases: goitre (N = 21), autoimmune diseases (N = 16), and carcinomas (N = 32). …”
Publicado 2011
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998por de Goër de Herve, Marie-Ghislaine, Durali, Deniz, Dembele, Bamory, Giuliani, Massimo, Tran, Tu-Anh, Azzarone, Bruno, Eid, Pierre, Tardieu, Marc, Delfraissy, Jean-François, Taoufik, Yassine“…These results point to a coordinated action of IFN-α, IFN-γ and IL-12 in Be1 polarization of naive B-cells, and may provide new insights into the mechanisms by which type-I-interferons favor autoimmunity.…”
Publicado 2011
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999“…BACKGROUND: Type I interferons (IFN) are a heterogeneous group of cytokines central to innate and adaptive antiviral immune responses. …”
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1000por Todoric, Jelena, Strobl, Birgit, Jais, Alexander, Boucheron, Nicole, Bayer, Martina, Amann, Sabine, Lindroos, Josefine, Teperino, Raffaele, Prager, Gerhard, Bilban, Martin, Ellmeier, Wilfried, Krempler, Franz, Müller, Mathias, Wagner, Oswald, Patsch, Wolfgang, Pospisilik, J. Andrew, Esterbauer, Harald“…OBJECTIVE: T cells and level of the cytokine interferon-γ (IFN-γ) are increased in adipose tissue in obesity. …”
Publicado 2011
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