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1041“…METHODS: Herein we studied whether the combined effect of several stimuli known to take part in CKD progression, namely TGF-β, tumor necrosis factor-α, interferon-γ (IFN-γ), and Fas stimulation, on primed resistant human tubular cells caused cell death or reduced proliferation. …”
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1042por Adewole, Olanisun Olufemi, Ota, Martin O., Erhabor, Greg E., Owiafe, Patrick, Oladimeji, Aliu, Obaseki, Daniel“…INTRODUCTION: Interferon-γ (IFN-γ) is essential for defence against Mycobacterium tuberculosis; however, levels in patients with active tuberculosis (TB) and changes during treatment have not been documented in our tuberculosis patients in Nigeria, hence this study has been carried out. …”
Publicado 2013
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1043
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1044“…For more than 20 years after the excitement engendered by their discovery in 1957 as antiviral agents, there were no significant clinical uses of interferons; however, following their cloning they have been employed as effective treatment for several viral, autoimmune, and neoplastic diseases.…”
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1045por Hartl, Janine, Ott, Claudia, Kirchner, Gabriele, Salzberger, Bernd, Wiest, Reiner“…In conclusion, pegylated-interferon plus ribavirin may be an effective therapy for HCV, HBV and HDV-coinfected patients.…”
Publicado 2012
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1046“…Interferon-gamma (IFN-γ) is a glycoprotein generated by lymphocytes that possesses anti-tumor, antiviral and immunomodulatory functions. …”
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1047“…Type I interferons (IFNs) are pleiotropic cytokines, initially described for their antiviral activity. …”
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1048por Zheng, Lian-Shun, Hitoshi, Seiji, Kaneko, Naoko, Takao, Keizo, Miyakawa, Tsuyoshi, Tanaka, Yasuhito, Xia, Hongjing, Kalinke, Ulrich, Kudo, Koutaro, Kanba, Shigenobu, Ikenaka, Kazuhiro, Sawamoto, Kazunobu“…Depression is a common and serious side effect of interferon-α (IFN-α), which limits its use as an antiviral and antitumor drug. …”
Publicado 2014
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1049por Aizawa, Nobuhiro, Enomoto, Hirayuki, Takashima, Tomoyuki, Sakai, Yoshiyuki, Iwata, Kazunari, Ikeda, Naoto, Tanaka, Hironori, Iwata, Yoshinori, Saito, Masaki, Imanishi, Hiroyasu, Iijima, Hiroko, Nishiguchi, Shuhei“…BACKGROUND: This study aimed to examine the therapeutic effect and prognostic indicators of pegylated interferon (PEG-IFN) and ribavirin (RBV) combination therapy in thrombocytopenic patients with chronic hepatitis C, hepatitis C virus (HCV)-related cirrhosis, and those who underwent splenectomy or partial splenic embolization (PSE). …”
Publicado 2013
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1050“…Interferon (IFN) beta-1b was the first disease-modifying therapy to be approved for the treatment of multiple sclerosis (MS), and over 21 years of follow-up data demonstrate its efficacy and long-term safety profile. …”
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1051por Andrade, Danieli, Kim, Mimi, Blanco, Luz P, Karumanchi, S Ananth, Koo, Gloria C, Redecha, Patricia, Kirou, Kyriakos, Alvarez, Angela M, Mulla, Melissa J, Crow, Mary K, Abrahams, Vikki M, Kaplan, Mariana J, Salmon, Jane EEnlace del recurso
Publicado 2014
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1052por Carnero, Elena, Barriocanal, Marina, Segura, Victor, Guruceaga, Elizabeth, Prior, Celia, Börner, Kathleen, Grimm, Dirk, Fortes, Puri“…Interferons (IFNs) are key players in the antiviral response. …”
Publicado 2014
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1053por Cha, Lilian, Berry, Cassandra M, Nolan, David, Castley, Allison, Fernandez, Sonia, French, Martyn A“…Type I interferons (IFNs) exert anti-viral effects through the induction of numerous IFN-stimulated genes and an immunomodulatory effect on innate and adaptive immune responses. …”
Publicado 2014
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1054“…We present an immunoassay for Interferon-γ (IFN-γ) with a limit of detection of 1.9 pM (30 pg/mL) and a linear concentration range spanning three orders of magnitude. …”
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1055por Lin, Lan, Pan, Shan, Zhao, Jianqing, Liu, Cheng, Wang, Pingan, Fu, Lei, Xu, Xinlin, Jin, Meilin, Zhang, Anding“…The production of IFN- I (IFN-α/β) is one of the earliest and most important host-protective responses. Interferon regulatory factor 3 (IRF3) is a critical transcriptional factor in the IFN-β signaling pathway. …”
Publicado 2014
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1057por Torres, Martha, García-García, Lourdes, Cruz-Hervert, Pablo, Guio, Heinner, Carranza, Claudia, Ferreyra-Reyes, Leticia, Canizales, Sergio, Molina, Susana, Ferreira-Guerrero, Elizabeth, Téllez, Norma, Montero-Campos, Rogelio, Delgado-Sánchez, Guadalupe, Mongua-Rodriguez, Norma, Sifuentes-Osornio, Jose, Ponce-de Leon, Alfredo, Sada, Eduardo, Young, Douglas B., Wilkinson, Robert J.“…Assays of in vitro interferon (IFN)-γ secretion in response to recombinant Rv1737 and overlapping synthetic peptide pools from various groups of immunodominant proteins were performed. …”
Publicado 2015
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1059“…This method involves special media recipes that promote growth to high density and automatically induce expression of target protein from T7 promoter. Consensus interferon is a synthetic artificially engineered interferon having an amino acid sequence that is a rough average of the sequences of all natural human alpha interferon subtypes and has greater potency than other interferons even the pegylated versions. …”
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1060Conceptus elongation in ruminants: roles of progesterone, prostaglandin, interferon tau and cortisol“…This review integrates established and new information on the biological role of ovarian progesterone (P4), prostaglandins (PGs), interferon tau (IFNT) and cortisol in endometrial function and conceptus elongation. …”
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