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1081por Ní Cheallaigh, Clíona, Sheedy, Frederick J., Harris, James, Muñoz-Wolf, Natalia, Lee, Jinhee, West, Kim, McDermott, Eva Palsson, Smyth, Alicia, Gleeson, Laura E., Coleman, Michelle, Martinez, Nuria, Hearnden, Claire H.A., Tynan, Graham A., Carroll, Elizabeth C., Jones, Sarah A., Corr, Sinéad C., Bernard, Nicholas J., Hughes, Mark M., Corcoran, Sarah E., O’Sullivan, Mary, Fallon, Ciara M., Kornfeld, Hardy, Golenbock, Douglas, Gordon, Stephen V., O’Neill, Luke A.J., Lavelle, Ed C., Keane, Joseph“…We report that Mal has a TLR-independent role in interferon-gamma (IFN-γ) receptor signaling. Mal-dependent IFN-γ receptor (IFNGR) signaling led to mitogen-activated protein kinase (MAPK) p38 phosphorylation and autophagy. …”
Publicado 2016
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1082“…Thus, bacterial suppression of autophagy not only enhances cell-autonomous survival but also suppresses more-systemic innate immune responses by limiting type I and type II interferons.…”
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1083por Vitner, Einat B., Farfel-Becker, Tamar, Ferreira, Natalia Santos, Leshkowitz, Dena, Sharma, Piyush, Lang, Karl S., Futerman, Anthony H.“…RESULTS: The 10 most up-regulated genes in the ventral posteromedial/posterolateral region of the thalamus were inflammatory genes, with the gene expression signature significantly enriched in interferon signaling genes. Interferon β levels were elevated in neurons, and interferon-stimulated genes were elevated mainly in microglia. …”
Publicado 2016
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1084por Lückoff, Anika, Caramoy, Albert, Scholz, Rebecca, Prinz, Marco, Kalinke, Ulrich, Langmann, Thomas“…Complete deletion of interferon‐α/β receptor (Ifnar) using Ifnar1(−/−) mice significantly enhanced early microglia and macrophage activation in lesion areas. …”
Publicado 2016
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1085“…In the United States, HCV genotype 1 constitutes about 75% of all infections. While interferon and ribavirin therapy was the cornerstone of treatment for many years, interferon-free treatments have become the standard of care with the emergence of new direct-acting agents, resulting in more effective treatment, shorter duration of therapy, better tolerability, lower pill burden, and ultimately better adherence. …”
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1086por Taşkapılıoğlu, Mevlüt Özgür, Işık, Semra, Doğan, Şeref, Özgün, Gonca, Ocakoğlu, Gökhan, Uğraş, Nesrin“…PURPOSE: To investigate the effects of systemic and local interferon-beta-1a (IFN-β-1a) on prevention of epidural fibrosis using histopathological parameters. …”
Publicado 2016
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1087“…In the present study, we investigated how interferon (IFN)-α disrupts the extinction of conditioned fear and propose an approach to rescue IFN-α-induced neurologic impairment. …”
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1088“…We present a case of a young female with recurrent pericarditis due to interferon therapy. The role of interferon in adjuvant chemotherapy is well known and yields good effect, but this case highlights the very uncommon phenomena of interferon induced pericarditis and the significant distress it can cause.…”
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1089por Boyd, David F., Sharma, Amit, Humes, Daryl, Cheng-Mayer, Cecilia, Overbaugh, Julie“…Lentiviruses are able to establish persistent infection in their respective hosts despite a potent type-I interferon (IFN-I) response following transmission. …”
Publicado 2016
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1090por Cardenas-Garcia, Stivalis, Dunwoody, Robert P., Marcano, Valerie, Diel, Diego G., Williams, Robert J., Gogal, Robert M., Brown, Corrie C., Miller, Patti J., Afonso, Claudio L.“…The use of chicken interferon gamma (chIFNγ) during vaccination is a potentially important but controversial approach that may improve the immune response to antigens. …”
Publicado 2016
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1091por Filiano, Anthony J., Xu, Yang, Tustison, Nicholas J., Marsh, Rachel L., Baker, Wendy, Smirnov, Igor, Overall, Christopher C., Gadani, Sachin P., Turner, Stephen D., Weng, Zhiping, Peerzade, Sayeda Najamussahar, Chen, Hao, Lee, Kevin S., Scott, Michael M., Beenhakker, Mark P., Litvak, Vladimir, Kipnis, Jonathan“…Associations between rodent transcriptomes from brain and cellular transcriptomes in response to T cell–derived cytokines suggest a strong interaction between social behavior and interferon-gamma (IFN-γ) driven responses. Concordantly, we demonstrate that inhibitory neurons respond to IFN-γ and increase GABAergic currents in projection neurons, suggesting that IFN-γ is a molecular link between meningeal immunity and neural circuits recruited for social behavior. …”
Publicado 2016
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1093por Kanzaki, Hiroyuki, Shinohara, Fumiaki, Suzuki, Maiko, Wada, Satoshi, Miyamoto, Yutaka, Yamaguchi, Yuuki, Katsumata, Yuta, Makihira, Seicho, Kawai, Toshi, Taubman, Martin A., Nakamura, Yoshiki“…Interferon-gamma (IFN-γ) is a pleiotropic cytokine that exerts anti-tumor and anti-osteoclastogenic effects. …”
Publicado 2016
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1094por Ren, Wenkai, Chen, Shuai, Zhang, Liwen, Liu, Gang, Hussain, Tarique, Hao, Xiao, Yin, Jie, Duan, Jielin, Tan, Bie, Wu, Guoyao, Bazer, Fuller W., Yin, Yulong“…This study was conducted to explore the effects of interferon tau (IFNT) on the intestinal microbiota and expression of interleukin 17 (IL-17) in the intestine of mice. …”
Publicado 2016
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1095por Ranganath, Nischal, Sandstrom, Teslin S., Fadel, Saleh, Côté, Sandra C., Angel, Jonathan B.“…Significant impairment of the type I interferon (IFN-I) response is observed during productive HIV-1 infection. …”
Publicado 2016
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1096por Yan, Wei, Lee, Hookeun, Yi, Eugene C, Reiss, David, Shannon, Paul, Kwieciszewski, Bartlomiej K, Coito, Carlos, Li, Xiao-jun, Keller, Andrew, Eng, Jimmy, Galitski, Timothy, Goodlett, David R, Aebersold, Ruedi, Katze, Michael G“…BACKGROUND: Interferons (IFNs) play a critical role in the host antiviral defense and are an essential component of current therapies against hepatitis C virus (HCV), a major cause of liver disease worldwide. …”
Publicado 2004
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1097por Hong, MeeAe, Schwerk, Johannes, Lim, Chrissie, Kell, Alison, Jarret, Abigail, Pangallo, Joseph, Loo, Yueh-Ming, Liu, Shuanghu, Hagedorn, Curt H., Gale, Michael, Savan, Ram“…Interferon (IFN) lambdas are critical antiviral effectors in hepatic and mucosal infections. …”
Publicado 2016
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1098“…The human interferon (IFN) response is a key innate immune mechanism to fight virus infection. …”
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1099“…Cutaneous reactions associated with interferons (IFNs) treatment are either localized or generalized. …”
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1100“…Post-translational protein modifications by ubiquitin and ubiquitin-like proteins, including SUMO and NEDD8, are critically involved in DNA damage response (DDR) and DNA damage tolerance (DDT). The expression of interferon-stimulated gene 15 (ISG15), the first identified ubiquitin-like protein, has recently been shown to be induced under various DNA damage conditions, such as exposure to UV, camptothecin, and doxorubicin. …”
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