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1101por Hoan, Nghiem Xuan, Tong, Hoang Van, Giang, Dao Phuong, Toan, Nguyen Linh, Meyer, Christian G., Bock, C.-Thomas, Kremsner, Peter G., Song, Le Huu, Velavan, Thirumalaisamy P.“…This study investigates the association of Interferon-stimulated gene 15 (ISG15) polymorphisms, ISG15 serum levels and expression with HBV-related liver diseases. …”
Publicado 2016
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1102“…BACKGROUND: Type I interferons are major players against viral infections and mediate their function by the induction of Interferon regulated genes (IRGs). …”
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1103“…This finding could contribute to explain the differential signaling (antiviral vs apoptotic) depending on interferon dose and subtype (α vs β) observed in type I interferons.…”
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1104por Engin, Ayse Basak, Engin, Evren Doruk, Golokhvast, Kirill, Spandidos, Demetrios A., Tsatsakis, Aristides M.“…Thus, the aim of this study was to investigate whether the severity of MeHg- and HgCl(2)-mediated cytotoxicity to SH-SY5Y human dopaminergic neurons can be attenuated by regulating glutamate-mediated signal-transmission through caffeine and interferon-γ (IFN-γ). The SH-SY5Y cells were exposed to 1, 2 and 5 μM of either MeHgCl(2) or HgCl(2) in the presence or absence of L-glutamine. …”
Publicado 2017
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1105“…In order to efficiently establish a productive infection in mammalian cells, flaviviruses have developed key strategies to counteract host immune defences, including the type I interferon response. They employ different mechanisms to control interferon signal transduction and effector pathways, and key research generated over the past couple of decades has uncovered new insights into their abilities to actively decrease interferon antiviral activity. …”
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1106por Madsen, Claus“…The continuous development of interferons over the past two decades outlines a journey with increased understanding of the pharmacodynamics and pharmacokinetic mechanisms of interferons, leading to innovative formulations with an improved benefit/risk profile.…”
Publicado 2017
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1107“…In mice, the control of A. phagocytophilum in the early phase of infection is dependent on natural killer cell-derived interferon-γ (IFN-γ). In contrast, the final elimination strictly requires CD4(+) T-cells. …”
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1108por López-Rodríguez, Rosario, Hernández-Bartolomé, Ángel, Borque, María Jesús, Rodríguez-Muñoz, Yolanda, Martín-Vílchez, Samuel, García-Buey, Luisa, González-Moreno, Leticia, Real-Martínez, Yolanda, Muñoz de Rueda, Paloma, Salmerón, Javier, Vidal-Castiñeira, José Ramón, López-Larrea, Carlos, Rodrigo, Luis, Moreno-Otero, Ricardo, Sanz-Cameno, Paloma“…CONCLUSION: The identified genetic variants in interferon signaling pathways may constitute useful prognostic markers of CHC progression. …”
Publicado 2017
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1109“…A predisposition to autoimmunity associated with the presence of baseline autoantibodies has been demonstrated in interferon mediated autoimmune diseases. We report a male patient, 34 years old, with genotype 1, chronic hepatitis C (hepatitis C viremia 1.432.463 UI/mL) and family history of psoriasis. …”
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1110
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1111por Stanifer, Megan L., Kischnick, Christian, Rippert, Anja, Albrecht, Dorothee, Boulant, Steeve“…In this study, we unraveled that MRV induces a replication-dependent global reduction in interferon-mediated antiviral immune response. We determined that although MRV leads to the activation and phosphorylation of interferon regulatory factor 3 (IRF3), the nuclear translocation of IRF3 was impaired in infected cells. …”
Publicado 2017
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1112“…A link between genetics, the immune system, and environmental factors are type 1 interferons (T1-IFNs). These cytokines are well known for inducing antiviral factors that limit infection by regulating innate and adaptive immune responses. …”
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1113
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1114“…Type III interferons (IFNs), also termed lambda IFNs (IFNλs) or interleukins-28/29, constitute a new addition to the IFN family. …”
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1115por Kay, Alexander, Islam, Shamim, Wendorf, Kristen, Westenhouse, Janice, Barry, Pennan“…BACKGROUND: Interferon Gamma Release Assays (IGRAs) and Tuberculin Skin Tests (TSTs) are important adjunctive pediatric TB diagnostics. …”
Publicado 2017
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1116Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapypor Medrano, Ruan F.V., Hunger, Aline, Mendonça, Samir Andrade, Barbuto, José Alexandre M., Strauss, Bryan E.“…During the last decades, the pleiotropic antitumor functions exerted by type I interferons (IFNs) have become universally acknowledged, especially their role in mediating interactions between the tumor and the immune system. …”
Publicado 2017
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1117
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1118“…Urgent needs in the fight against TB include improved and innovative treatment options for drug-sensitive and -resistant TB as well as reliable biological indicators that discriminate active from latent disease and enable monitoring of treatment success or failure. Prominent interferon (IFN) inducible gene signatures in TB patients and animal models of Mycobacterium tuberculosis infection have drawn significant attention to the roles of type I IFNs in the host response to mycobacterial infections. …”
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1119por Qiu, Hui, Weng, Dong, Chen, Tao, Shen, Li, Chen, Shan-Shan, Wei, Ya-Ru, Wu, Qin, Zhao, Meng-Meng, Li, Qiu-Hong, Hu, Yang, Zhang, Yuan, Zhou, Ying, Su, Yi-Liang, Zhang, Fen, Lu, Li-Qin, Zhou, Nian-Yu, Li, Sen-Lin, Zhang, Le-Le, Wang, Chen, Li, Hui-Ping“…The stimulator of interferon genes (STING) is a key adaptor protein mediating innate immune defense against DNA viruses. …”
Publicado 2017
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1120por Rodero, Mathieu P., Tesser, Alessandra, Bartok, Eva, Rice, Gillian I., Della Mina, Erika, Depp, Marine, Beitz, Benoit, Bondet, Vincent, Cagnard, Nicolas, Duffy, Darragh, Dussiot, Michael, Frémond, Marie-Louise, Gattorno, Marco, Guillem, Flavia, Kitabayashi, Naoki, Porcheray, Fabrice, Rieux-Laucat, Frederic, Seabra, Luis, Uggenti, Carolina, Volpi, Stefano, Zeef, Leo A H., Alyanakian, Marie-Alexandra, Beltrand, Jacques, Bianco, Anna Monica, Boddaert, Nathalie, Brouzes, Chantal, Candon, Sophie, Caorsi, Roberta, Charbit, Marina, Fabre, Monique, Faletra, Flavio, Girard, Muriel, Harroche, Annie, Hartmann, Evelyn, Lasne, Dominique, Marcuzzi, Annalisa, Neven, Bénédicte, Nitschke, Patrick, Pascreau, Tiffany, Pastore, Serena, Picard, Capucine, Picco, Paolo, Piscianz, Elisa, Polak, Michel, Quartier, Pierre, Rabant, Marion, Stocco, Gabriele, Taddio, Andrea, Uettwiller, Florence, Valencic, Erica, Vozzi, Diego, Hartmann, Gunther, Barchet, Winfried, Hermine, Olivier, Bader-Meunier, Brigitte, Tommasini, Alberto, Crow, Yanick J.“…We record increased interferon alpha protein levels using digital ELISA, enhanced interferon signaling by RNA-Seq analysis and constitutive upregulation of phosphorylated STAT1 and STAT3 in patient lymphocytes and monocytes. …”
Publicado 2017
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