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  1. 1181
    “…The innate immune system fights infection with inflammasomes and interferons. Facultative bacterial pathogens that inhabit the host cytosol avoid inflammasomes(1–6) and are often insensitive to type I interferons (IFN-I), but are restricted by IFN-γ(7–11). …”
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    Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis
  2. 1182
    “…A hyperglycosylated recombinant human interferon-β (rhIFN-β) R27T mutant was established to improve relapsing-remitting multiple sclerosis (RRMS) in our previous study. …”
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    Stability and Activity of the Hyperglycosylated Human Interferon-β R27T Variant
  3. 1183
    “…Here we show that the delta-globin mRNA level is considerably increased in a Deoxyribonuclease II-alpha knockout mouse model in which type 1 interferon (interferon beta, IFNb) is activated. IFNb activation in the fetal liver improves the delta-globin mRNA level, while the beta-globin mRNA level is significantly reduced. …”
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    Delta-Globin Gene Expression Is Enhanced in vivo by Interferon Type I
  4. 1184
    “…We show that activation of the type I interferon (IFN)/IFNα receptor (IFNAR) axis amplifies adipocyte inflammatory vigor and uncovers dormant gene expression patterns resembling inflammatory myeloid cells. …”
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    Type I interferon sensing unlocks dormant adipocyte inflammatory potential
  5. 1185
    “…Previous studies showed that ASFV developed mechanisms to evade type I interferon (IFN) responses. Hence, we analyzed the ability of ASFV strains of diverse virulence to modulate IFN-β and IFN-α responses. …”
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    Modulation of Type I Interferon System by African Swine Fever Virus
  6. 1186
    “…The Stimulator of Interferon Genes (STING) pathway initiates potent immune responses upon recognition of DNA. …”
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    Interferon-independent STING signaling promotes resistance to HSV-1 in vivo
  7. 1187
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    Reply to Jakovac: COVID-19, vitamin D, and type I interferon
  8. 1188
    “…Tightly interlinked feedback regulators control the dynamics of intracellular responses elicited by the activation of signal transduction pathways. Interferon alpha (IFNα) orchestrates antiviral responses in hepatocytes, yet mechanisms that define pathway sensitization in response to prestimulation with different IFNα doses remained unresolved. …”
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    Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction
  9. 1189
    por How, Joan, Hobbs, Gabriela
    Publicado 2020
    “…Interferon alfa was first used in the treatment of myeloproliferative neoplasms (MPNs) over 30 years ago. …”
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    Use of Interferon Alfa in the Treatment of Myeloproliferative Neoplasms: Perspectives and Review of the Literature
  10. 1190
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    Patients with interferon expressing oral pathologies are susceptible to COVID-19 infection
  11. 1191
    “…In this study, we combine microfluidics, time-lapse microscopy, and computational modeling to investigate how the type I interferon (IFN)-responsive regulatory network operates in single human cells to process repetitive IFN stimulation. …”
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    Cell-cycle-gated feedback control mediates desensitization to interferon stimulation
  12. 1192
    “…We studied placental mRNA expression of 136 genes by sequencing and HLA-G and interferon alpha (IFNα) protein expression by immunohistochemistry. …”
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    Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia
  13. 1193
    “…We identified an unexpected antagonistic effect of FGFs on the interferon (IFN) signaling pathway. Genetic or pharmacological inhibition of FGF receptor signaling in keratinocytes promoted the expression of interferon‐stimulated genes (ISG) and proteins in vitro and in vivo. …”
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    Antagonism of interferon signaling by fibroblast growth factors promotes viral replication
  14. 1194
    “…The concept that type I interferons (IFN-I) are essential to antiviral immunity derives from studies on animal models and cell lines. …”
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    Genetic Lesions of Type I Interferon Signalling in Human Antiviral Immunity
  15. 1195
    “…Type I Interferon (IFN) signaling plays an important role in the immune defense system against virus infection and in the innate immune response, thus IFNs are widely used as anti-viral agents and treatment for immune disorder or cancer. …”
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    Design, synthesis, and biological evaluation of N-arylpiperazine derivatives as interferon inducers
  16. 1196
    “…There is a well-established link between immune activation and depression, such as following the administration of the pro-inflammatory cytokine, interferon-α (IFN-α), used to treat hepatitis C viral (HCV) infection. …”
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    Differential effect of interferon-alpha treatment on AEA and 2-AG levels
  17. 1197
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    Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling
  18. 1198
    “…DNA-damaging cancer therapies induce interferon expression and stimulate the immune system, promoting therapy responses. …”
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    Photochemotherapy Induces Interferon Type III Expression via STING Pathway
  19. 1199
    “…Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases.…”
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    Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation
  20. 1200
    “…Interferons (IFNs) constitute the first line of defense against microbial infections particularly against viruses. …”
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    Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces
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