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1181por Burke, Thomas P., Engström, Patrik, Chavez, Roberto A., Fonbuena, Joshua A., Vance, Russell E., Welch, Matthew D.“…The innate immune system fights infection with inflammasomes and interferons. Facultative bacterial pathogens that inhabit the host cytosol avoid inflammasomes(1–6) and are often insensitive to type I interferons (IFN-I), but are restricted by IFN-γ(7–11). …”
Publicado 2020
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1182“…A hyperglycosylated recombinant human interferon-β (rhIFN-β) R27T mutant was established to improve relapsing-remitting multiple sclerosis (RRMS) in our previous study. …”
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1183por Manchinu, Maria Francesca, Simbula, Michela, Caria, Cristian Antonio, Musu, Ester, Perseu, Lucia, Porcu, Susanna, Steri, Maristella, Poddie, Daniela, Frau, Jessica, Cocco, Eleonora, Manunza, Laura, Barella, Susanna, Ristaldi, Maria Serafina“…Here we show that the delta-globin mRNA level is considerably increased in a Deoxyribonuclease II-alpha knockout mouse model in which type 1 interferon (interferon beta, IFNb) is activated. IFNb activation in the fetal liver improves the delta-globin mRNA level, while the beta-globin mRNA level is significantly reduced. …”
Publicado 2020
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1184por Chan, Calvin C., Damen, Michelle S. M. A., Moreno-Fernandez, Maria E., Stankiewicz, Traci E., Cappelletti, Monica, Alarcon, Pablo C., Oates, Jarren R., Doll, Jessica R., Mukherjee, Rajib, Chen, Xiaoting, Karns, Rebekah, Weirauch, Matthew T., Helmrath, Michael A., Inge, Thomas H., Divanovic, Senad“…We show that activation of the type I interferon (IFN)/IFNα receptor (IFNAR) axis amplifies adipocyte inflammatory vigor and uncovers dormant gene expression patterns resembling inflammatory myeloid cells. …”
Publicado 2020
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1185por Razzuoli, Elisabetta, Franzoni, Giulia, Carta, Tania, Zinellu, Susanna, Amadori, Massimo, Modesto, Paola, Oggiano, Annalisa“…Previous studies showed that ASFV developed mechanisms to evade type I interferon (IFN) responses. Hence, we analyzed the ability of ASFV strains of diverse virulence to modulate IFN-β and IFN-α responses. …”
Publicado 2020
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1186por Yamashiro, Lívia H., Wilson, Stephen C., Morrison, Huntly M., Karalis, Vasiliki, Chung, Jing-Yi J., Chen, Katherine J., Bateup, Helen S., Szpara, Moriah L., Lee, Angus Y., Cox, Jeffery S., Vance, Russell E.“…The Stimulator of Interferon Genes (STING) pathway initiates potent immune responses upon recognition of DNA. …”
Publicado 2020
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1187
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1188por Kok, Frédérique, Rosenblatt, Marcus, Teusel, Melissa, Nizharadze, Tamar, Gonçalves Magalhães, Vladimir, Dächert, Christopher, Maiwald, Tim, Vlasov, Artyom, Wäsch, Marvin, Tyufekchieva, Silvana, Hoffmann, Katrin, Damm, Georg, Seehofer, Daniel, Boettler, Tobias, Binder, Marco, Timmer, Jens, Schilling, Marcel, Klingmüller, Ursula“…Tightly interlinked feedback regulators control the dynamics of intracellular responses elicited by the activation of signal transduction pathways. Interferon alpha (IFNα) orchestrates antiviral responses in hepatocytes, yet mechanisms that define pathway sensitization in response to prestimulation with different IFNα doses remained unresolved. …”
Publicado 2020
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1189“…Interferon alfa was first used in the treatment of myeloproliferative neoplasms (MPNs) over 30 years ago. …”
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1190por Sarode, Gargi S., Sarode, Sachin C., Gadbail, Amol R., Gondivkar, Shailesh, Kumar Sharma, Nilesh, Patil, ShankargoudaEnlace del recurso
Publicado 2020
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1191por Mudla, Anusorn, Jiang, Yanfei, Arimoto, Kei-ichiro, Xu, Bingxian, Rajesh, Adarsh, Ryan, Andy P, Wang, Wei, Daugherty, Matthew D, Zhang, Dong-Er, Hao, Nan“…In this study, we combine microfluidics, time-lapse microscopy, and computational modeling to investigate how the type I interferon (IFN)-responsive regulatory network operates in single human cells to process repetitive IFN stimulation. …”
Publicado 2020
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1192por Wedenoja, Satu, Yoshihara, Masahito, Teder, Hindrek, Sariola, Hannu, Gissler, Mika, Katayama, Shintaro, Wedenoja, Juho, Häkkinen, Inka M., Ezer, Sini, Linder, Nina, Lundin, Johan, Skoog, Tiina, Sahlin, Ellika, Iwarsson, Erik, Pettersson, Karin, Kajantie, Eero, Mokkonen, Mikael, Heinonen, Seppo, Laivuori, Hannele, Krjutškov, Kaarel, Kere, Juha“…We studied placental mRNA expression of 136 genes by sequencing and HLA-G and interferon alpha (IFNα) protein expression by immunohistochemistry. …”
Publicado 2020
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1193por Maddaluno, Luigi, Urwyler, Corinne, Rauschendorfer, Theresa, Meyer, Michael, Stefanova, Debora, Spörri, Roman, Wietecha, Mateusz, Ferrarese, Luca, Stoycheva, Diana, Bender, Daniela, Li, Nick, Strittmatter, Gerhard, Nasirujjaman, Khondokar, Beer, Hans‐Dietmar, Staeheli, Peter, Hildt, Eberhard, Oxenius, Annette, Werner, Sabine“…We identified an unexpected antagonistic effect of FGFs on the interferon (IFN) signaling pathway. Genetic or pharmacological inhibition of FGF receptor signaling in keratinocytes promoted the expression of interferon‐stimulated genes (ISG) and proteins in vitro and in vivo. …”
Publicado 2020
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1194“…The concept that type I interferons (IFN-I) are essential to antiviral immunity derives from studies on animal models and cell lines. …”
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1195por Chu, Yeonjeong, Raja Sekhara Reddy, B., Pratap Reddy Gajulapalli, V., Sudhakar Babu, K., Kim, Eunha, Lee, Sanghee“…Type I Interferon (IFN) signaling plays an important role in the immune defense system against virus infection and in the innate immune response, thus IFNs are widely used as anti-viral agents and treatment for immune disorder or cancer. …”
Publicado 2020
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1196por Zajkowska, Zuzanna, Borsini, Alessandra, Nikkheslat, Naghmeh, Russell, Alice, Romano, Graziella F., Tomassi, Simona, Hepgul, Nilay, Forton, Daniel, Agarwal, Kosh, Hotopf, Matthew, Mondelli, Valeria, Zunszain, Patricia, Pariante, Carmine M.“…There is a well-established link between immune activation and depression, such as following the administration of the pro-inflammatory cytokine, interferon-α (IFN-α), used to treat hepatitis C viral (HCV) infection. …”
Publicado 2020
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1197por Lepelley, Alice, Martin-Niclós, Maria José, Le Bihan, Melvin, Marsh, Joseph A., Uggenti, Carolina, Rice, Gillian I., Bondet, Vincent, Duffy, Darragh, Hertzog, Jonny, Rehwinkel, Jan, Amselem, Serge, Boulisfane-El Khalifi, Siham, Brennan, Mary, Carter, Edwin, Chatenoud, Lucienne, Chhun, Stéphanie, Coulomb l’Hermine, Aurore, Depp, Marine, Legendre, Marie, Mackenzie, Karen J., Marey, Jonathan, McDougall, Catherine, McKenzie, Kathryn J., Molina, Thierry Jo, Neven, Bénédicte, Seabra, Luis, Thumerelle, Caroline, Wislez, Marie, Nathan, Nadia, Manel, Nicolas, Crow, Yanick J., Frémond, Marie-LouiseEnlace del recurso
Publicado 2020
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1198por Biskup, Edyta, Larsen, Brian Daniel, Rib, Leonor, Folkersen, Lasse, Niazi, Omid, Kamstrup, Maria R., Sørensen, Claus Storgaard“…DNA-damaging cancer therapies induce interferon expression and stimulate the immune system, promoting therapy responses. …”
Publicado 2020
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1199por Zhang, Qian, Bastard, Paul, Bolze, Alexandre, Jouanguy, Emmanuelle, Zhang, Shen-Ying, Cobat, Aurélie, Notarangelo, Luigi D., Su, Helen C., Abel, Laurent, Casanova, Jean-Laurent“…Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases.…”
Publicado 2020
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1200“…Interferons (IFNs) constitute the first line of defense against microbial infections particularly against viruses. …”
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