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1201por Kazakov, Alexey S., Sofin, Alexander D., Avkhacheva, Nadezhda V., Denesyuk, Alexander I., Deryusheva, Evgenia I., Rastrygina, Victoria A., Sokolov, Andrey S., Permyakova, Maria E., Litus, Ekaterina A., Uversky, Vladimir N., Permyakov, Eugene A., Permyakov, Sergei E.“…Interferon-β (IFN-β) is a pleiotropic cytokine used for therapy of multiple sclerosis, which is also effective in suppression of viral and bacterial infections and cancer. …”
Publicado 2020
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1202“…Various antiviral drugs have recently been tested. Type I interferon (IFN) is a regulatory protein involved in the innate immune response, with broad‐spectrum antiviral activities and the ability to directly block viral replication and support the immune response to eliminate virus infection. …”
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1203por Li, Yu, Jiang, Ning, Mao, Yaqing, Zhang, Wenbo, Xiao, Jing, Wu, Xiangdong, Wu, Huansheng“…Chicken MDA5 (chMDA5), the essential accepted pattern recognition receptors for detecting cytoplasmic viral RNA in chicken, initiates interferon β (IFN-β) generation. However, there is an incomplete elucidation of regulating chMDA5-mediated IFN-β production. …”
Publicado 2020
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1205por Bryson, Bryan D.“…In this mSphere of Influence article, he reflects on how “IRG1 and inducible nitric oxide synthase act redundantly with other interferon-gamma-induced factors to restrict intracellular replication of Legionella pneumophila” by Price and colleagues (J. …”
Publicado 2021
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1206“…Pestiviruses can prevent interferon (IFN) production to avoid the host innate immune response, and the N(pro) viral protein can play a critical role. …”
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1208por Shu, Hairong, Li, Yong, Xu, Hangyu, Yin, Qing, Song, Jianxin, Zheng, Minqiao, Li, He“…Interferon (IFN) plays a role in immune and inflammation responses. …”
Publicado 2021
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1209por Zhou, Yunlian, Li, Mengyao, Lv, Tingyi, Huang, Meixia, Cheng, Beilei, Zhang, Yuanyuan, Zhu, Jie“…Type I interferon (IFN-I) plays a critical role in the antiviral immune response. …”
Publicado 2021
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1210“…One of the most powerful and multifaceted cytokines produced by immune cells are type I interferons (IFNs), the basal secretion of which contributes to the maintenance of immune homeostasis, while their activation-induced production is essential to effective immune responses. …”
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1211“…BACKGROUND: The Type I interferon response is an important first-line defense against viruses. …”
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1212por Sosa, Juan Pablo, Ferreira Caceres, Maria Mercedes, Ross Comptis, Jennifer, Quiros, Jorge, Príncipe-Meneses, Fortunato S, Riva-Moscoso, Adrian, Belizaire, Marie-Pierre, Malanyaon, Freda Q., Agadi, Kuchalambal, Jaffery, Syeda Sheharbano, Sahajwani, Juhi, Arshia, Asma, Senatus, Andrelle, Verdecia, Graciela, Akano, Lordstrong, Razzack, Aminah Abdul, Salam, Sanna, Gadamidi, Vinay Kumar, Marian, Sheeba“…We aim to review the efficacy and safety of Interferon Beta (IFN-β) in patients who have a confirmed COVID-19 diagnosis. …”
Publicado 2021
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1213“…Recently, cases have been described in otherwise healthy individuals with neutralizing antibodies to interferon-gamma (nIFNγ-autoAb), especially in patients of Southeast Asian descent. …”
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1214por Assanto, Giovanni M., Riemma, Costantino, Malaspina, Francesco, Perrone, Salvatore, De Luca, Maria L., Pucciarini, Alessandra, Annechini, Giorgia, D'Elia, Gianna M., Martelli, Maurizio, Foà, Robin, Tiacci, Enrico, Pulsoni, Alessandro“…We investigated the current role of interferon‐alpha (IFNα) in hairy cell leukaemia (HCL) in a retrospective analysis of patients with HCL. …”
Publicado 2021
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1215por Sposito, Benedetta, Broggi, Achille, Pandolfi, Laura, Crotta, Stefania, Clementi, Nicola, Ferrarese, Roberto, Sisti, Sofia, Criscuolo, Elena, Spreafico, Roberto, Long, Jaclyn M., Ambrosi, Alessandro, Liu, Enju, Frangipane, Vanessa, Saracino, Laura, Bozzini, Sara, Marongiu, Laura, Facchini, Fabio A., Bottazzi, Andrea, Fossali, Tommaso, Colombo, Riccardo, Clementi, Massimo, Tagliabue, Elena, Chou, Janet, Pontiroli, Antonio E., Meloni, Federica, Wack, Andreas, Mancini, Nicasio, Zanoni, Ivan“…Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction of immune mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) families remains debated. …”
Publicado 2021
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1216por Murphy, Eain A.“…Albanese, et al., mBio 12:e03440-20, 2021, https://doi.org/10.1128/mBio.03440-20) revisits the impact of virus-encoded noncoding RNAs on key components of the interferon pathway and sheds light on how the extensive biological functions of Epstein-Barr virus (EBV) microRNAs (miRNAs) are on targeting both the induction and signaling cascades of interferon.…”
Publicado 2021
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1217por Bolko, Loïs, Jiang, Wei, Tawara, Nozomu, Landon‐Cardinal, Océane, Anquetil, Céline, Benveniste, Olivier, Allenbach, Yves“…Moreover, the pathophysiological mechanisms are distinct between each myositis subsets. Recently, interferon (IFN) pathways have been identified as key players implicated in the pathophysiology of myositis. …”
Publicado 2021
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1219“…Down syndrome (DS) is a unique genetic disease caused by the presence of an extra copy of chromosome 21, which carries four of the six interferon receptor (IFN-R) genes on its long arm. Recent studies reporting higher levels of interferon-stimulated gene (ISG) expression in primary immune cells studied ex vivo have suggested that the additional copies of the IFN-R genes in DS result in mild interferonopathy. …”
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1220por Kirby, Duncan, Parmar, Baljyot, Fathi, Sepehr, Marwah, Sagar, Nayak, Chitra R., Cherepanov, Vera, MacParland, Sonya, Feld, Jordan J., Altan-Bonnet, Grégoire, Zilman, Anton“…We use a minimal computational model of Type I Interferon signaling, focusing on Interferon-α and Interferon-β. …”
Publicado 2021
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