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1261
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1262“…INTRODUCTION: The diagnosis of latent tuberculosis infection (LTBI) relies largely on the tuberculin skin test (TST) or, more recently, on interferon‐gamma release assays (IGRA). Knowledge regarding these tests is essential to improve their usefulness in combating the tuberculosis epidemic. …”
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1263por Casal-Dominguez, Maria, Pinal-Fernandez, Iago, Pak, Katherine, Muñoz-Braceras, Sandra, Milisenda, Jose C., Torres-Ruiz, Jiram, Dell′Orso, Stefania, Naz, Faiza, Gutierrez-Cruz, Gustavo, Duque-Jaimez, Yaiza, Matas-Garcia, Ana, Valls-Roca, Laura, Garrabou, Gloria, Trallero-Araguas, Ernesto, Walitt, Brian, Christopher-Stine, Lisa, Lloyd, Thomas E., Paik, Julie J., Albayda, Jemima, Corse, Andrea, Grau, Josep Maria, Selva-O’Callaghan, Albert, Mammen, Andrew L.“…In this study, bulk RNA sequencing (RNAseq) analyses of muscle biopsy specimens revealed that complement genes are locally overexpressed and correlate with markers of myositis disease activity, including the expression of interferon-gamma (IFNγ)-induced genes. Single cell and single nuclei RNAseq analyses showed that most local expression of complement genes occurs in macrophages, fibroblasts, and satellite cells, with each cell type expressing different sets of complement genes. …”
Publicado 2023
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1264por Zhang, Hailing, Zhang, Dongliang, Zhang, Shasha, Liu, Hao, Wang, Han, Wang, Cong, Zou, Deying, Hu, Bo, Lian, Shizhen, Lu, Shiying, Bai, Xue“…The interferon (IFN) response is the first line of defense against viral invasion and thus plays a central role in the regulation of the immune response. …”
Publicado 2023
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1265“…Since their original discovery, type I interferons (IFN-Is) have been closely associated with antiviral immune responses. …”
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1266
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1267“…The development of effective therapeutic and prevention strategies for protozoan-caused diseases requires a full understanding of the pathogenesis and protective events occurring in infected hosts. Interferons (IFNs) are a family of cytokines with diverse biological effects in host antimicrobial defense and disease pathogenesis, including protozoan parasite infection. …”
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1268por Giersch, Katja, Perez-Gonzalez, Paulina, Hendricks, Lennart, Goldmann, Nora, Kolbe, Jonathan, Hermanussen, Lennart, Bockmann, Jan-Hendrick, Volz, Tassilo, Volmari, Annika, Allweiss, Lena, Petersen, Joerg, Glebe, Dieter, Lütgehetmann, Marc, Dandri, Maura“…BACKGROUND & AIMS: Pegylated interferon alpha (pegIFNα) is commonly used for the treatment of people infected with HDV. …”
Publicado 2023
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1269por Ota, H, Nagano, H, Sakon, M, Eguchi, H, Kondo, M, Yamamoto, T, Nakamura, M, Damdinsuren, B, Wada, H, Marubashi, S, Miyamoto, A, Dono, K, Umeshita, K, Nakamori, S, Wakasa, K, Monden, M“…We previously reported the beneficial effects of combination therapy of interferon (IFN)-α/5-fluorouracil (FU) for advanced hepatocellular carcinoma (HCC) with tumour thrombi in the major portal branches. …”
Publicado 2005
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1270“…We have previously shown that adenoviral-mediated interferon α (Ad-IFNα) treatment is highly cytotoxic to tumor cells which are resistant to the interferon α̣ protein. …”
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1271por Furuya, Nobutaka, Kamai, Takao, Shirataki, Hiromichi, Yanai, Yoshiaki, Fukuda, Takehiko, Mizuno, Tomoya, Nakamura, Fumihiko, Kambara, Tsunehito, Nakanishi, Kimihiro, Abe, Hideyuki, Yoshida, Ken-Ichiro“…BACKGROUND: Interferon (IFN) alpha is one of the central agents in immunotherapy for renal cell carcinoma (RCC). …”
Publicado 2011
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1272por Giotis, Efstathios S., Robey, Rebecca C., Skinner, Natalie G., Tomlinson, Christopher D., Goodbourn, Stephen, Skinner, Michael A.“…Although interferon was discovered in chicken cells, details of the response, particularly the identity of hundreds of stimulated genes, are far better described in mammals. …”
Publicado 2016
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1273por Tamai, Hideyuki, Ida, Yoshiyuki, Kawashima, Akira, Shingaki, Naoki, Shimizu, Ryo, Moribata, Kosaku, Nasu, Tetsushi, Maekita, Takao, Iguchi, Mikitaka, Kato, Jun, Nakao, Taisei, Kitano, Masayuki“…BACKGROUND/AIMS: The present study aimed to evaluate the safety and efficacy of simeprevir-based triple therapy with reduced doses of pegylated interferon (PEG-IFN) and ribavirin for interferon (IFN) ineligible patients, such as elderly and/or cirrhotic patients, and to elucidate the factors contributing to a sustained virologic response (SVR). …”
Publicado 2017
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1274“…After he achieved major molecular response (MMR) or less, it was possible to suppress IS% to DMR by performing a combined treatment with interferon-α (IFN-α) and ponatinib. It is considered that DMR can be maintained by the combination of the two-way action of IFN-α, that is, the transfer of dormant CML stem cells to the cellcycle and the activation of a specific immune response to CML cells. …”
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1275por Chen, Shan Nan, Gan, Zhen, Hou, Jing, Yang, Yue Cong, Huang, Lin, Huang, Bei, Wang, Su, Nie, Pin“…Interferons (IFNs) are critical soluble factors in the immune system and are composed of three types, (I, II and III) that utilize different receptor complexes IFN-αR1/IFN-αR2, IFN-γR1/IFN-γR2, and IFN-λR1/IL-10R2, respectively. …”
Publicado 2022
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1276por Luqman-Fatah, Ahmad, Watanabe, Yuzo, Uno, Kazuko, Ishikawa, Fuyuki, Moran, John V., Miyoshi, TomoichiroEnlace del recurso
Publicado 2023
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1277por Huang, Yin-Qiu, Tang, Sheng-Quan, Xu, Xiao-Lei, Zeng, Yan-Ming, He, Xiao-Qing, Li, Yao, Harypursat, Vijay, Lu, Yan-Qiu, Wan, Yan, Zhang, Lu, Sun, Qiang-Zhong, Sun, Nan-Nan, Wang, Gui-Xue, Yang, Zhong-Ping, Chen, Yao-Kai“…Eligible patients with mild to moderate COVID-19 were randomized into three groups: ribavirin (RBV) plus interferon-α (IFN-α), lopinavir/ritonavir (LPV/r) plus IFN-α, and RBV plus LPV/r plus IFN-α at a 1:1:1 ratio. …”
Publicado 2020
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1278Publicado 1976“…The effect of potent sheep anti-mouse interferon globulin was investigated in several different experimental virus diseases of mice. …”
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1279“…We therefore investigated the effects of interferons (IFNs), which strongly induce IRF-1, on VCAM-1 transcription and expression. …”
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1280por Veldt, Bart J, Brouwer, Johannes T, Adler, Michael, Nevens, Frederik, Michielsen, Peter, Delwaide, Jean, Hansen, Bettina E, Schalm, Solko W“…DISCUSSION: This belated report on the only placebo controlled study of interferon ribavirin combination therapy in non responders to standard doses of interferon monotherapy documents the effectiveness, be it limited, of this approach as well as the dynamics of the effects on blood counts.…”
Publicado 2003
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