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1281por Miyamoto, Rie, Ito, Tomoki, Nomura, Shosaku, Amakawa, Ryuichi, Amuro, Hideki, Katashiba, Yuichi, Ogata, Makoto, Murakami, Naoko, Shimamoto, Keiko, Yamazaki, Chihiro, Hoshino, Katsuaki, Kaisho, Tsuneyasu, Fukuhara, Shirou“…INTRODUCTION: Plasmacytoid dendritic cells (pDCs) play not only a central role in the antiviral immune response in innate host defense, but also a pathogenic role in the development of the autoimmune process by their ability to produce robust amounts of type I interferons (IFNs), through sensing nucleic acids by toll-like receptor (TLR) 7 and 9. …”
Publicado 2010
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1282por Li, Lian-Feng, Yu, Jiahui, Zhang, Yuexiu, Yang, Qian, Li, Yongfeng, Zhang, Lingkai, Wang, Jinghan, Li, Su, Luo, Yuzi, Sun, Yuan, Qiu, Hua-Ji“…Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), which poses a serious threat to the global pig industry. Interferons (IFNs) and IFN-stimulated genes (ISGs) play a key role in host antiviral defense. …”
Publicado 2017
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1283por Seyfi, Shahram, Latifi, Kayvan, Amri male, Parviz, Sadeghi Haddad Zavareh, Mahmoud, Ezoji, Khadijeh, Mohammadnia-Afrozi, Mousa“…This study aimed to investigate the effects of treatment with INF-β 1-a (interferon beta-1a) and IFN-β 1-b (interferon beta-1b) on COVID-19 inpatients. …”
Publicado 2021
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1284por Jacques, Camille, Chatelais, Mathias, Fekir, Karim, Brulefert, Adrien, Floris, Ilaria“…As a cytokine, gamma-interferon (IFN-γ) is considered a key player in the fine-tuned orchestration of immune responses. …”
Publicado 2022
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1285por Kang, Ning, Shi, Yuanyuan, Song, Jiaxi, Gao, Fei, Fan, Mingyue, Jin, Wei, Gao, Yaran, Lv, Peiyuan“…Inflammatory responses induced by chronic cerebral hypoperfusion (CCH) play a critical role in the progression of vascular dementia. Stimulator of interferon genes (STING) signaling function as a key mediator of inflammation and immunological responses in the central nervous system (CNS), and resveratrol (RES) exerts potent anti-inflammatory effects. …”
Publicado 2022
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1287por Darif, Dounia, Ejghal, Rajaâ, Desterke, Christophe, Outlioua, Ahmed, Hammi, Ikram, Lemrani, Meryem, Hilali, Farida, Guessous, Fadila, Zaid, Younes, Akarid, Khadija“…Type I (-α/β) and Type III (IFN-λ) interferons are family members of cytokines that play an important role in fighting viral replication during the early phases of infection. …”
Publicado 2023
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1288por Tronina, Olga, Brzdęk, Michał, Zarębska-Michaluk, Dorota, Dybowska, Dorota, Lorenc, Beata, Janczewska, Ewa, Mazur, Włodzimierz, Parfieniuk-Kowerda, Anna, Piekarska, Anna, Krygier, Rafał, Klapaczyński, Jakub, Berak, Hanna, Jaroszewicz, Jerzy, Garlicki, Aleksander, Tomasiewicz, Krzysztof, Citko, Jolanta, Flisiak, RobertEnlace del recurso
Publicado 2023
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1289por Chotiwan, Nunya, Rosendal, Ebba, Willekens, Stefanie M. A., Schexnaydre, Erin, Nilsson, Emma, Lindqvist, Richard, Hahn, Max, Mihai, Ionut Sebastian, Morini, Federico, Zhang, Jianguo, Ebel, Gregory D., Carlson, Lars-Anders, Henriksson, Johan, Ahlgren, Ulf, Marcellino, Daniel, Överby, Anna K.“…We combine multimodal imaging (cm-nm scale) with single nuclei RNA-sequencing to study Langat virus in wildtype and interferon alpha/beta receptor knockout (Ifnar(–/–)) mice to visualize viral pathogenesis and define molecular mechanisms. …”
Publicado 2023
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1290por MacLauchlan, Susan, Kushwaha, Priyanka, Tai, Albert, Chen, Jia, Manning, Catherine, Swarnkar, Gaurav, Abu-Amer, Yousef, Fitzgerald, Katherine A., Sharma, Shruti, Gravallese, Ellen M.“…Stimulator of interferon genes (STING) is a key mediator of type-I interferon (IFN-I) signaling in response to a variety of stimuli, but the contribution of STING to homeostatic processes is not fully characterized. …”
Publicado 2023
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1293por Unali, Giulia, Crivicich, Giovanni, Pagani, Isabel, Abou‐Alezz, Monah, Folchini, Filippo, Valeri, Erika, Matafora, Vittoria, Reisz, Julie A, Giordano, Anna Maria Sole, Cuccovillo, Ivan, Butta, Giacomo M, Donnici, Lorena, D'Alessandro, Angelo, De Francesco, Raffaele, Manganaro, Lara, Cittaro, Davide, Merelli, Ivan, Petrillo, Carolina, Bachi, Angela, Vicenzi, Elisa, Kajaste‐Rudnitski, Anna“…The interferon‐induced transmembrane proteins (IFITM) are implicated in several biological processes, including antiviral defense, but their modes of action remain debated. …”
Publicado 2023
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1295por Jürgens, Carina, Ssebyatika, George, Beyer, Sarah, Plückebaum, Nina, Kropp, Kai A., González-Motos, Víctor, Ritter, Birgit, Böning, Heike, Nikolouli, Eirini, Kinchington, Paul R., Lachmann, Nico, Depledge, Daniel Pearce, Krey, Thomas, Viejo-Borbolla, Abel“…This results in the expression of cytokines, including interferons (IFNs) which partly limit primary infection. …”
Publicado 2023
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1296por Lim, Juhee, Kang, In, La, Jeongwoo, Ku, Keun Bon, Kang, Byeong Hoon, Kim, Yumin, Park, Won Hyung, Lee, Heung Kyu“…Type I interferons have long been appreciated as a cytokine family that regulates antiviral immunity. …”
Publicado 2023
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1297por Xavier, Alexandre, Campagna, Maria Pia, Maltby, Vicki E., Kilpatrick, Trevor, Taylor, Bruce V., Butzkueven, Helmut, Ponsonby, Anne-Louise, Scott, Rodney J., Jokubaitis, Vilija G., Lea, Rodney A., Lechner-Scott, Jeannette“…RESULTS: We show that IFNβ treatment in people with MS modifies the methylation profile of interferon response genes in a strong, targeted, and reproducible manner. …”
Publicado 2023
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1298por Tichauer, Juan E., Arellano, Gabriel, Acuña, Eric, González, Luis F., Kannaiyan, Nirmal R., Murgas, Paola, Panadero-Medianero, Concepción, Ibañez-Vega, Jorge, Burgos, Paula I., Loda, Eileah, Miller, Stephen D., Rossner, Moritz J., Gebicke-Haerter, Peter J., Naves, Rodrigo“…Compelling evidence has shown that interferon (IFN)-γ has dual effects in multiple sclerosis and in its animal model of experimental autoimmune encephalomyelitis (EAE), with results supporting both a pathogenic and beneficial function. …”
Publicado 2023
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1299por Samuel, Charles E.“…This virus was identified as the pathogen responsible for the severe respiratory disease, coronavirus disease-19 (COVID-19), which as of May 2023, has killed an estimated 6.9 million people globally according to the World Health Organization. The interferon (IFN) response, a cornerstone of antiviral innate immunity, plays a key role in determining the outcome of infection by SARS-CoV-2. …”
Publicado 2023
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1300por Jung, Yun Jung, Park, Ji Eun, Park, Ji Won, Lee, Keu Sung, Chung, Wou Young, Park, Joo Hun, Sheen, Seung Soo, You, Seulgi, Sun, Joo Sung, Park, Kyung Joo, Kim, Youn Jung, Park, Kwang Joo“…PURPOSE: To address the limited utility of the interferon (IFN)-γ release assay (IGRA) caused by its variability and inconsistency. …”
Publicado 2023
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