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1301por Tehrani, Sahar SH, Mikulski, Pawel, Abdul‐Zani, Izma, Mata, João F, Siwek, Wojciech, Jansen, Lars ET“…Exposure of human cells to interferon‐γ (IFNγ) results in a mitotically heritable yet reversible state called long‐term transcriptional memory. …”
Publicado 2023
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1302por López-Rodríguez, Juan Carlos, Hancock, Steven J., Li, Kelin, Crotta, Stefania, Barrington, Christopher, Suárez-Bonnet, Alejandro, Priestnall, Simon L., Aubé, Jeffrey, Wack, Andreas, Klenerman, Paul, Bengoechea, Jose A., Barral, Patricia“…Here, we use Klebsiella pneumoniae as a model of bacterial pneumonia and demonstrate that MAIT cell activation is independent of MR1 and primarily driven by type I interferons (IFNs). During Klebsiella infection, type I IFNs stimulate activation of murine and human MAIT cells, induce a Th1/cytotoxic transcriptional program, and modulate MAIT cell location within the lungs. …”
Publicado 2023
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1304por Wang, Kerong, Zhang, Jian, Yang, Yongheng, Si, Yue, Zhou, Ziqing, Zhu, Xudong, Wu, Sushan, Liu, He, Zhang, Hui, Zhang, Liang, Cheng, Linfeng, Ye, Wei, Lv, Xin, Lei, Yingfeng, Zhang, Xijing, Cheng, Shilin, Shen, Lixin, Zhang, Fanglin, Ma, Hongwei“…Here, we demonstrate that the stimulator of interferon genes (STING) strengthens the host IFN-independent anti-hantaviral immunity. …”
Publicado 2023
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1305“…Bladder cancer is a prevalent malignancy with limited therapeutic options, particularly for patients who are unresponsive to Bacillus Calmette-Guérin (BCG). The approval of interferon-α (IFNα) gene therapy with nadofaragene firadenovec (Adstiladrin(®)), the first gene therapy for genitourinary malignancies, has provided a promising alternative. …”
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1306por Zhang, Bingqing, Fan, Junpin, Huang, Chengjing, Fan, Hongwei, Chen, Jialin, Huang, Xiaoming, Zeng, Xuejun“…PURPOSE: Anti-interferon gamma antibody (AIGA) is a rare cause of adult onset immunodeficiency, leading to severe disseminated opportunistic infections with varying outcomes. …”
Publicado 2023
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1307por Jung, Kwang Il, McKenna, Savannah, Vijayamahantesh, Vijayamahantesh, He, Ying, Hahm, Bumsuk“…Following virus infections, type I interferons are synthesized to induce the expression of antiviral molecules and interfere with virus replication. …”
Publicado 2023
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1308por Clancy, Anne, Rusilowicz-Jones, Emma V., Wallace, Iona, Swatek, Kirby N., Urbé, Sylvie, Clague, Michael J.“…Type 1 interferon stimulation highly up-regulates all elements of a ubiquitin-like conjugation system that leads to ISGylation of target proteins. …”
Publicado 2023
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1309por Uhl, Lion F. K., Cai, Han, Oram, Sophia L., Mahale, Jagdish N., MacLean, Andrew J., Mazet, Julie M., Piccirilli, Theo, He, Alexander J., Lau, Doreen, Elliott, Tim, Gerard, AudreyEnlace del recurso
Publicado 2023
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1310por Zhang, Shu, Xie, Na, Liu, Yongzhen, Qin, Chao, Savas, Ali Can, Wang, Ting-Yu, Li, Shutong, Rao, Youliang, Shambayate, Alexandra, Chou, Tsui-Fen, Brenner, Charles, Huang, Canhua, Feng, Pinghui“…Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the salvage NAD(+) synthesis, is an interferon-inducible protein that inhibits the replication of several RNA and DNA viruses with unknown mechanism. …”
Publicado 2023
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1311por Arteaga-Rivera, José Y., Vigderovich-Cielak, Itamar, Ramirez-Miranda, Arturo, González, Andrea, Frías-Jimenez, Emmanuel, Arriaga-Guzman, Ivonne E., Sierra Madero, Juan G., Navas, Alejandro, Graue-Hernandez, Enrique O.“…PURPOSE: The aim of this study was to report a case of ocular Mpox that responded favorably to treatment with topical interferon and oral doxycycline. METHODS: This is a case report of a previously healthy 24-year-old woman who developed a pustular rash, headache, fever, arthralgia, sore throat, and asthenia 3 weeks before attending to our clinic. …”
Publicado 2023
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1312por Carreno-Florez, Grace P., Kocak, Brian R., Hendricks, Matthew R., Melvin, Jeffrey A., Mar, Katrina B., Kosanovich, Jessica, Cumberland, Rachel L., Delgoffe, Greg M., Shiva, Sruti, Empey, Kerry M., Schoggins, John W., Bomberger, Jennifer M.“…In experimental models in vitro and in vivo, virus-induced interferon responses can augment host susceptibility to secondary bacterial infection. …”
Publicado 2023
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1313“…The body’s first line of defense against viral infections is provided by the interferon (IFN) response. This antiviral defense mechanism takes place in two waves, namely the induction of type I IFNs triggered by viral infection, followed by the IFN signaling pathway, which leads to the synthesis of interferon-stimulated genes (ISGs), whose products inhibit viral replication. …”
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1314por Stroncek, David F, Basil, Christopher, Nagorsen, Dirk, Deola, Sara, Aricó, Eleonora, Smith, Kina, Wang, Ena, Marincola, Francesco M, Panelli, Monica C“…BACKGROUND: Interferon (IFN)-α is considered a key modulator of immunopathological processes through a signature-specific activation of mononuclear phagocytes (MPs). …”
Publicado 2005
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1315por Dewan, Puneet Kumar, Grinsdale, Jennifer, Liska, Sally, Wong, Ernest, Fallstad, Robert, Kawamura, L Masae“…BACKGROUND: The whole-blood interferon-gamma release assay (IGRA) is recommended in some settings as an alternative to the tuberculin skin test (TST). …”
Publicado 2006
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1316“…In the current study we examined the effects of interferon (IFN)-γ, tumour necrosis factor (TNF)α, interleukin (IL)-1β and IL-6 on neurons. …”
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1317por Speziali, E, Bethony, J, Martins-Filho, O, Fraga, L A O, Lemos, D S, Souza, L J, Correa-Oliveira, R, Faria, A M C“…RESULTS: We demonstrated that the frequency of CD16+ interferon-gamma (IFN-gamma)+ natural killer cells in negative individuals over the age of 70 years is significantly higher than in positive individuals after in vitro stimulation with S. mansoni antigen extracts. …”
Publicado 2004
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1318“…We investigated the regulation of human PML expression by interferons (IFNs) and IL-1 in various human haematopoietic lines (U937, THP1, HL60, NB4), in human diploid fibroblasts and in human peripheral blood leukocytes. …”
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1319por Lee, Bang-Ning, Hammill, Hunter, Popek, Edwina J., Cron, Stanley, Kozinetz, Claudia, Paul, Mary, Shearer, William T., Reuben, James M.“…Objective: The mechanism whereby the placental cells of a human immunodeficiency virus (HIV)-1-infected mother protect the fetus from HIV-1 infection is unclear. Interferons (IFNs) inhibit the replication of viruses by acting at various stages of the life cycle and may play a role in protecting against vertical transmission of HIV-1. …”
Publicado 2001
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1320por Critchley-Thorne, Rebecca J, Yan, Ning, Nacu, Serban, Weber, Jeffrey, Holmes, Susan P, Lee, Peter P“…CONCLUSIONS: Defects in interferon signaling represent novel, dominant mechanisms of immune dysfunction in cancer. …”
Publicado 2007
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