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1361por Kisand, Kai, Link, Maire, Wolff, Anette S. B., Meager, Anthony, Tserel, Liina, Org, Tõnis, Murumägi, Astrid, Uibo, Raivo, Willcox, Nick, Trebušak Podkrajšek, Katarina, Battelino, Tadej, Lobell, Anna, Kämpe, Olle, Lima, Kari, Meloni, Antonella, Ergun-Longmire, Berrin, Maclaren, Noel K., Perheentupa, Jaakko, Krohn, Kai J. E., Scott, Hamish S., Husebye, Eystein S., Peterson, Pärt“…Neutralizing autoantibodies to type I, but not type II, interferons (IFNs) are found at high titers in almost every patient with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED), a disease caused by AIRE gene mutations that lead to defects in thymic T-cell selection. …”
Publicado 2008
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1362por Papic, Natasa, Hunn, Julia P., Pawlowski, Nikolaus, Zerrahn, Jens, Howard, Jonathan C.“…Irga6, a myristoylated, interferon-inducible member of the immunity-related GTPase family, contributes to disease resistance against Toxoplasma gondii in mice. …”
Publicado 2008
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1363“…BACKGROUND: Type-I interferons, type-II interferons, and the IL-10 family are helical cytokines with similar three-dimensional folds. …”
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1364por Sauzullo, Ilaria, Mengoni, Fabio, Lichtner, Miriam, Massetti, Anna Paola, Rossi, Raffaella, Iannetta, Marco, Marocco, Raffaella, Borgo, Cosmo Del, Soscia, Fabrizio, Vullo, Vincenzo, Mastroianni, Claudio Maria“…BACKGROUND: In recent years, the impact of antituberculous treatment on interferon (IFN)-γ response to Mycobacterium tuberculosis antigens has been widely investigated, but the results have been controversial. …”
Publicado 2009
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1365por Yang, Long, Zhao, Tiejun, Shi, Xiaoliu, Nakhaei, Peyman, Wang, Yunling, Sun, Qiang, Hiscott, John, Lin, Rongtuan“…BACKGROUND: Interferon regulatory factor (IRF) family members have been implicated as critical transcription factors that function in immune response, hematopoietic differentiation and cell growth regulation. …”
Publicado 2009
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1366“…The regulation mechanism of interferon (IFN) and IFN-stimulated genes is a very complex procedure and is dependent on cell types and virus species. …”
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1367por Xu, Dakang, Holko, Michelle, Sadler, Anthony J., Scott, Bernadette, Higashiyama, Shigeki, Berkofsky-Fessler, Windy, McConnell, Melanie J., Pandolfi, Pier Paolo, Licht, Jonathan D., Williams, Bryan R.G.“…Interferons (IFNs) direct innate and acquired immune responses and, accordingly, are used therapeutically to treat a number of diseases, yet the diverse effects they elicit are not fully understood. …”
Publicado 2009
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1368“…Chlamydiae are obligate intracellular pathogens that are sensitive to pro-inflammatory cytokine interferon-γ. IFN-γ-inducible murine p47 GTPases have been demonstrated to function in resistance to chlamydia infection in vivo and in vitro. …”
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1369“…The outcome data from prospective clinical trials that studied interferon and ribavirin therapy was then mapped onto this new tree. …”
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1370“…Since the 1990s the results of several clinical trials with immunomodulatory agents have changed the therapeutic approach to this disease. Interferon beta (IFNβ)-1b represents the pioneer of those therapies. …”
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1371por Huys, Liesbeth, Van Hauwermeiren, Filip, Dejager, Lien, Dejonckheere, Eline, Lienenklaus, Stefan, Weiss, Siegfried, Leclercq, Georges, Libert, Claude“…We report that type I interferons (IFNs) are essential mediators of the lethal response to TNF. …”
Publicado 2009
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1372“…Through activation of transcription factors, such as interferon regulatory factor-3, 5, and 7 (IRF-3, 5, 7) or nuclear factor-κB (NF-κB), type I interferons are induced, and antiviral proteins such as myxovirus-resistance protein (Mx) GTPase, RNA-dependent Protein Kinase (PKR), ribonuclease L (RNase L), Oligo-adenylate Synthetase (OAS) and Interferon Stimulated Gene (ISG) are further expressed. …”
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1373
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1374“…While there are many studies of the adaptive immune response to MHV, there has until recently been scant information on the type I interferon (IFN) response to MHV. The relationship between MHV and the IFN-α/β response is paradoxical. …”
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1375por Lesinski, Gregory B, Zimmerer, Jason M, Kreiner, Melanie, Trefry, John, Bill, Matthew A, Young, Gregory S, Becknell, Brian, Carson, William E“…We investigated the role of negative regulators of interferon signaling known as suppressors of cytokine signaling (SOCS) in mediating interferon-resistance in human melanoma cells. …”
Publicado 2010
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1376“…The interferons are a complex group of virally induced proteins produced by activated macrophages and lymphocytes, which have become the mainstay of therapy for hepatitis C infection. …”
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1378por Navarro, Francisco, Bacurau, Aline V. N., Vanzelli, Andréa, Meneguello-Coutinho, Marcela, Uchida, Marco C., Moraes, Milton R., Almeida, Sandro S., Wasinski, Frederick, Barros, Carlos C., Würtele, Martin, Araújo, Ronaldo C., Costa Rosa, Luís F. B., Bacurau, Reury F. P.Enlace del recurso
Publicado 2010
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1379
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1380“…OBJECTIVE: This study clarified characteristics of interferon-associated type 1 diabetes. RESEARCH DESIGN AND METHODS: The study compared 12 patients with interferon-associated type 1 diabetes with 128 patients with type 1A diabetes with respect to clinical characteristics, and with 10 patients without diabetes despite interferon therapy and 136 normal controls with respect to HLA allele distributions. …”
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