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1381
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1382“…The intracellular mechanism by which interferon-gamma induces the expression of class II major histocompatibility complex (MHC) antigen in nonlymphoid cells is not clear. …”
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1383por Walter, Janine, Honsek, Silke D, Illes, Sebastian, Wellen, Jennifer M, Hartung, Hans-Peter, Rose, Christine R, Dihné, Marcel“…BACKGROUND: The identification of factors that compromise neurogenesis is aimed at improving stem cell-based approaches in the field of regenerative medicine. Interferon gamma (IFNγ) is a main pro-inflammatory cytokine and up-regulated during several neurological diseases. …”
Publicado 2011
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1384“…BACKGROUND: Signaling events triggered by interferon (IFN) account for the molecular mechanisms of antiviral effect. …”
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1385
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1386por Parker, Dane, Martin, Francis J., Soong, Grace, Harfenist, Bryan S., Aguilar, Jorge L., Ratner, Adam J., Fitzgerald, Katherine A., Schindler, Christian, Prince, Alice“…The mucosal epithelium is the initial target for respiratory pathogens of all types. While type I interferon (IFN) signaling is traditionally associated with antiviral immunity, we demonstrate that the extracellular bacterial pathogen Streptococcus pneumoniae activates the type I IFN cascade in airway epithelial and dendritic cells. …”
Publicado 2011
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1387“…Interferon-α, currently used for the treatment of hepatitis C, is associated with a substantially elevated risk of depression. …”
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1388“…METHODS: In this study, 165 outpatients and 133 healthy volunteers were included to investigate the role of HBHA in TB diagnosis including the serodiagnostic tests and the interferon-γ release assays (IGRAs). The healthy volunteers were all without BCG vaccination including 73 subjects with purified protein derivative (PPD) (-) and 60 ones with PPD (+) (that is P-B- and P+B-). …”
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1389“…It is generally thought that pathogen-associated molecular patterns (PAMPs) responsible for triggering interferon (IFN) induction are produced during virus replication and, to limit the activation of the IFN response by these PAMPs, viruses encode antagonists of IFN induction. …”
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1390
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1391por Tattermusch, Sonja, Skinner, Jason, Chaussabel, Damien, Banchereau, Jacques, Berry, Matthew P, O'Garra, Anne, Taylor, Graham P, Bangham, Charles R MEnlace del recurso
Publicado 2011
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1392por Seddik, Hassan, Tamzaourte, Mouna, Rouibaa, Fadoua, Fadlouallah, Maha, Benkirane, Ahmed“…Ophthalmologic complications with interferon therapy are rare and usually reversible. …”
Publicado 2011
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1393por Danilovic, Debora Lucia Seguro, Mendes-Correa, Maria Cassia, Chammas, Maria Cristina, Zambrini, Heverton, Marui, Suemi“…OBJECTIVE: To characterize thyroid disturbances induced by interferon-alpha and ribavirin therapy in patients with chronic hepatitis C. …”
Publicado 2011
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1394por Diamond, Mark S., Kinder, Michelle, Matsushita, Hirokazu, Mashayekhi, Mona, Dunn, Gavin P., Archambault, Jessica M., Lee, Hsiaoju, Arthur, Cora D., White, J. Michael, Kalinke, Ulrich, Murphy, Kenneth M., Schreiber, Robert D.“…We previously reported that type I interferon (IFN-α/β) plays a central role in this process and that hematopoietic cells represent critical targets of type I IFN’s actions. …”
Publicado 2011
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1395“…Resistance to Mycobacterium tuberculosis requires the host to restrict bacterial replication while preventing an over-exuberant inflammatory response. Interferon (IFN) γ is crucial for activating macrophages and also regulates tissue inflammation. …”
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1396por Jankovic, Slobodan M“…Immunomodulatory therapy with interferon beta-1b (IFN-β1b) or -1a, glatiramer and natalizumab shows similar efficacy; in a resistant or intolerant patient, the most recently approved therapeutic option is mitoxantrone. …”
Publicado 2010
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1397“…Among the 683 known unique genes with greater than 3-fold change in transcript abundance following FHA treatment, 125 (18.3%) were identified as interferon (IFN)-regulated. Among the latter group were genes encoding several members of the IFN type I response, as well as 3 key components of the ISGylation pathway. …”
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1398por Swiecki, Melissa, Wang, Yaming, Vermi, William, Gilfillan, Susan, Schreiber, Robert D., Colonna, Marco“…Plasmacytoid dendritic cells (pDCs) specialize in the secretion of type I interferons (IFN-I) and thus are considered critical mediators of antiviral responses. …”
Publicado 2011
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1399por Manion, Maura, Rodriguez, Benigno, Medvik, Kathleen, Hardy, Gareth, Harding, Clifford V., Schooley, Robert T., Pollard, Richard, Asmuth, David, Murphy, Robert, Barker, Edward, Brady, Kirsten E., Landay, Alan, Funderburg, Nick, Sieg, Scott F., Lederman, Michael M.“…BACKGROUND: Type I interferons play important roles in innate immune defense. …”
Publicado 2012
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