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1421por Hasan, Maroof, Koch, James, Rakheja, Dinesh, Pattnaik, Asit K., Brugarolas, James, Dozmorov, Igor, Levine, Beth, Wakeland, Edward K., Lee-kirsch, Min Ae, Yan, Nan“…Innate immune sensing of viral nucleic acids triggers type I interferon (IFN) production, which activates interferon-stimulated genes (ISGs) and directs a multifaceted antiviral response. …”
Publicado 2012
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1422por Rusinova, Irina, Forster, Sam, Yu, Simon, Kannan, Anitha, Masse, Marion, Cumming, Helen, Chapman, Ross, Hertzog, Paul J.“…Vastly improved computational infrastructure now enables more complex and faster queries, and supports more data sets from types I, II and III interferon (IFN)-treated cells, mice or humans. Quantitative, MIAME compliant data are collected, subjected to thorough, standardized, quantitative and statistical analyses and then significant changes in gene expression are uploaded. …”
Publicado 2013
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1423por George, Peter M., Cunningham, Morven E., Galloway-Phillipps, Neil, Badiger, Rekha, Alazawi, William, Foster, Graham R., Mitchell, Jane A.“…Endothelial cells are the physiological source of endothelin-1 but in vitro data from our group shows that interferons (IFNα, IFNβ or IFNγ) induce endothelin-1 in pulmonary vascular smooth muscle cells. …”
Publicado 2012
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1424“…We describe a case of a patient with a solitary fibrous tumor of kidney with malignant findings with distant metastasis and nephrectomy managed with subcutaneous interferon achieving 23 months of progression-free survival. …”
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1425por Kikkawa, Yasuko, Sugiyama, Kumiya, Obara, Kazuki, Hirata, Hirokuni, Fukushima, Yasutsugu, Toda, Masao, Fukuda, TakeshiEnlace del recurso
Publicado 2013
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1426por Liu, Ran-yi, Zhu, Ying-hui, Zhou, Ling, Zhao, Peng, Li, Hong-li, Zhu, Lan-cai, Han, Hong-yu, Lin, Huan-xin, Kang, Liang, Wu, Jiang-xue, Huang, Wenlin“…BACKGROUND: Interferon-γ (IFN-γ) is regarded as a potent antitumor agent, but its clinical application is limited by its short half-life and significant side effects. …”
Publicado 2012
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1427“…PURPOSE: To evaluate the feasibility of the interferon-gamma release assay (IGRA) as a supplementary diagnostic tool for the diagnosis of genitourinary tuberculosis (GUTB). …”
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1428“…We demonstrate that neuronal differentiation is associated with increased expression of crucial type I interferon signaling pathway components, including interferon regulatory factor-9 and an interferon receptor heterodimer subunit, which results in enhanced interferon stimulation and subsequent heightened antiviral activity and cytoprotective responses against neurotropic alphaviruses such as western equine encephalitis virus. …”
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1429por Kimura, Tominori, Jiang, Shiwen, Nishizawa, Mikio, Yoshigai, Emi, Hashimoto, Iwao, Nishikawa, Masao, Okumura, Tadayoshi, Yamada, Hisao“…Here, we show that natural antisense (AS) RNA is an important modulator of interferon-α1 (IFN-α1) mRNA levels. A ~4-kb, spliced IFN-α1 AS RNA targets a single-stranded region within a conserved secondary structure element of the IFN-α1 mRNA, an element which was previously reported to function as the nuclear export element. …”
Publicado 2012
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1430por Clapin, Alexis“…Three interferons are marketed for the treatment of relapsing-remitting multiple sclerosis. …”
Publicado 2012
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1431por Jadali, Zohreh“…In addition, research data suggest that interferon treatment may be associated with immune-mediated thyroid lesions. …”
Publicado 2013
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1432por Schmeisser, Hana, Fey, Samuel B., Horowitz, Julie, Fischer, Elizabeth R., Balinsky, Corey A., Miyake, Kotaro, Bekisz, Joseph, Snow, Andrew L., Zoon, Kathryn C.Enlace del recurso
Publicado 2013
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1433por Edwards, M R, Regamey, N, Vareille, M, Kieninger, E, Gupta, A, Shoemark, A, Saglani, S, Sykes, A, Macintyre, J, Davies, J, Bossley, C, Bush, A, Johnston, S L“…Deficient type I interferon-β and type III interferon-λ induction by rhinoviruses has previously been reported in mild/moderate atopic asthmatic adults. …”
Publicado 2013
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1434por Sorgeloos, Frédéric, Kreit, Marguerite, Hermant, Pascale, Lardinois, Cécile, Michiels, Thomas“…Type I and type III interferons (IFNs) are cytokines that are critical to control early steps of viral infections. …”
Publicado 2013
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1435“…The reason for the failure is currently unknown. Type I interferons (IFN) are a major component for the host innate immunity, and a key pathogenic factor in lupus. …”
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1436por Yu, Yanhua, Zhao, Xiuying, Wang, Wen, Wu, Hao, Chen, Ming, Hua, Wenhao, Wang, Huizhu, Wei, Ting, Jiao, Yanmei, Sun, Guizhen, Li, WeiEnlace del recurso
Publicado 2013
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1437por Tavakoli, Maryam, Pour Manshadi, Seyed Mohammad Yousof Mostafavi, Naderi, Nafiseh, Dehghan, Abolfazl, Azizi, Sanaz“…Probably, these are as side effects of interferon beta-1a injection. This is the first report according to our literature search (Pub Med, Google scholar, ISI web of knowledge, ProQuest, MD consult, Science Direct, and SCOPUS) about interferon beta-1a related abnormal kidney function tests hereafter. …”
Publicado 2012
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1438por Bosinger, Steven E., Johnson, Zachary P., Folkner, Kathryn A., Patel, Nirav, Hashempour, Tayebeh, Jochems, Simon P., del Rio Estrada, Perla M., Paiardini, Mirko, Lin, Rongtuan, Vanderford, Thomas H., Hiscott, John, Silvestri, Guido“…In 2008 it was reported that plasmacytoid dendritic cells (pDCs) of SMs exhibit attenuated interferon-alpha (IFN-α) responses to TLR7/9 ligands in vitro, and that species-specific amino acid substitutions in SM Interferon Regulatory Factor-7 (IRF7) are responsible for this observation. …”
Publicado 2013
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1439“…STAT1 and STAT2 proteins are key mediators of type I and type III interferon (IFN) signaling, and are essential components of the cellular antiviral response and adaptive immunity. …”
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1440“…BACKGROUND: The effect of interferon(IFN) in the management of hepatocellular carcinoma (HCC) remains controversial, and no clear recommendations have been proposed. …”
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