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1441“…Circulating autoantibodies can deposit in the tissue, causing inflammation and production of cytokines such as type 1 interferon (IFN). Investigations in human patients and animal models have implicated environmental as well as genetic factors in the biology of the SLE autoimmune response. …”
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1442por Lodermeyer, Veronika, Suhr, Kristina, Schrott, Nicola, Kolbe, Christian, Stürzel, Christina M, Krnavek, Daniela, Münch, Jan, Dietz, Christian, Waldmann, Tanja, Kirchhoff, Frank, Goffinet, Christine“…BACKGROUND: In response to viral infections, interferons induce the transcription of several hundred genes in mammalian cells. …”
Publicado 2013
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1443“…We tried to compare the effectiveness of intramuscular and subcutaneous interferon beta-1a (INF-β1a) in combination with oral doxycycline among patient with relapsing remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS). …”
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1444por Harari, Daniel, Abramovich, Renne, Zozulya, Alla, Smith, Paul, Pouly, Sandrine, Köster, Mario, Hauser, Hansjörg, Schreiber, Gideon“…We have generated transgenic mice that harbor humanized type I interferon receptors (IFNARs) enabling the study of type I human interferons (Hu-IFN-Is) in mice. …”
Publicado 2014
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1445“…Interferons (IFNs) are a family of naturally existing glycoproteins known for their antiviral activity and their ability to influence the behavior of normal and transformed cell types. …”
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1446por Kim, Cheol-Hong, Kim, Jong-Yeop, Hwang, Yong Il, Lee, Chang Youl, Choi, Jeong-Hee, Park, Yong-Bum, Jang, Seung-Hun, Woo, Heungjeong, Kim, Dong-Gyu, Lee, Myung Goo, Hyun, In-Gyu, Jung, Ki-Suck, Kim, Hyun Soo“…BACKGROUND: Interferon-γ assays based on tuberculosis (TB)-specific antigens have been utilized for diagnosing and ruling out latent TB and active TB, but their utility is still limited for TB incidence countries. …”
Publicado 2014
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1447por Dağ, Franziska, Dölken, Lars, Holzki, Julia, Drabig, Anja, Weingärtner, Adrien, Schwerk, Johannes, Lienenklaus, Stefan, Conte, Ianina, Geffers, Robert, Davenport, Colin, Rand, Ulfert, Köster, Mario, Weiß, Siegfried, Adler, Barbara, Wirth, Dagmar, Messerle, Martin, Hauser, Hansjörg, Čičin-Šain, Luka“…While it is known that type I interferon (IFN) limits lytic CMV replication, its role in latency and reactivation has not been explored. …”
Publicado 2014
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1448por Banerjee, Shuvojit, Chakrabarti, Arindam, Jha, Babal Kant, Weiss, Susan R., Silverman, Robert H.“…The interferon (IFN)-inducible antiviral state is mediated in part by the 2′,5′-oligoadenylate (2-5A) synthetase (OAS)/RNase L system. 2-5A, produced from ATP by OAS proteins in response to viral double-stranded RNA, binds to and activates RNase L. …”
Publicado 2014
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1450por Asmana Ningrum, Ratih“…Human interferon alpha (hIFNα) is a wide biological activity cytokine that is used in hepatitis and cancer treatments. …”
Publicado 2014
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1451por Salmannejad, Faranak, Nafissi-Varcheh, Nastaran, Shafaati, Alireza, Aboofazeli, Reza“…A major problem in the formulation of therapeutic proteins is the irreversible protein aggregation. Recombinant human interferon alpha2b (rhIFNα2b) has poor stability and undergoes physical degradation. …”
Publicado 2014
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1452por Magee, Kelsey E, Kelsey, Christina E, Kurzinski, Katherine L, Ho, Jonhan, Mlakar, Logan R, Feghali-Bostwick, Carol A, Torok, Kathryn S“…INTRODUCTION: The purpose of this study was to evaluate the presence and levels of interferon-gamma inducible protein-10 (IP-10) in the plasma and skin of pediatric localized scleroderma (LS) patients compared to those of healthy pediatric controls and to determine if IP-10 levels correlate to clinical disease activity measures. …”
Publicado 2013
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1453por Delsing, Corine E, Gresnigt, Mark S, Leentjens, Jenneke, Preijers, Frank, Frager, Florence Allantaz, Kox, Matthijs, Monneret, Guillaume, Venet, Fabienne, Bleeker-Rovers, Chantal P, van de Veerdonk, Frank L, Pickkers, Peter, Pachot, Alexandre, Kullberg, Bart Jan, Netea, Mihai G“…Based on pathophysiological mechanisms and limited pre-clinical and clinical data, adjunctive immune-stimulatory therapy with interferon-gamma (IFN-γ) may represent a promising candidate to improve outcome of invasive fungal infections by enhancing host defence mechanisms. …”
Publicado 2014
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1454
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1455“…To assess the effect of human interferon-alpha (IFNα) on shipping fever of Thoroughbred racehorses subjected to long-distance transportation, an IFNα preparation was orally administered to 48 horses three times (once daily, 3 successive days) before transportation (IFNα group). …”
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1456por Song, Kyoung, Yoon, In-Soo, Kim, Nam Ah, Kim, Dong-Hwan, Lee, Jongmin, Lee, Hee Jung, Lee, Saehyung, Choi, Sunghyun, Choi, Min-Koo, Kim, Ha Hyung, Jeong, Seong Hoon, Son, Woo Sung, Kim, Dae-Duk, Shin, Young Kee“…The purpose of this study was to develop a biobetter version of recombinant human interferon-β 1a (rhIFN-β 1a) to improve its biophysical properties, such as aggregation, production and stability, and pharmacokinetic properties without jeopardizing its activity. …”
Publicado 2014
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1457por Brod, Staley A.“…We have proposed a unifying hypothesis of the etiopathogenesis of autoimmunity that defines autoimmunity as a type I interferon (IFN) immunodeficiency syndrome. We have examined toxicity and potential efficacy in two phase I (type 1 diabetes [T1D], multiple sclerosis [MS]) and phase II clinical trials in T1D and MS. …”
Publicado 2010
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1458“…PURPOSE: To evaluate the usefulness of the interferon-gamma release assay (IGRA) for diagnosing tuberculosis (TB)-related uveitis (TRU). …”
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1459por Trien, Remi, Cooper, Chad J., Paez, David, Colon, Edgardo, Ajmal, Shajeea, Salameh, Hasan“…She had been treated for hepatitis C with telaprevir, ribavirin, and interferon-alpha-2b for 6 months. Chest radiograph showed bilateral diffuse prominence of bronchovascular markings. …”
Publicado 2014
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1460por Hodson, Andrew, Demontis, Maria-Antonietta, Cook, Lucy, Gillet, Nicolas, Melamed, Anat, Bangham, Charles RM, Taylor, Graham PEnlace del recurso
Publicado 2014
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