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  1. 1441
    “…Circulating autoantibodies can deposit in the tissue, causing inflammation and production of cytokines such as type 1 interferon (IFN). Investigations in human patients and animal models have implicated environmental as well as genetic factors in the biology of the SLE autoimmune response. …”
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    Nucleic Acid Sensors and Type I Interferon Production in Systemic Lupus Erythematosus
  2. 1442
    “…BACKGROUND: In response to viral infections, interferons induce the transcription of several hundred genes in mammalian cells. …”
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    90K, an interferon-stimulated gene product, reduces the infectivity of HIV-1
  3. 1443
    “…We tried to compare the effectiveness of intramuscular and subcutaneous interferon beta-1a (INF-β1a) in combination with oral doxycycline among patient with relapsing remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS). …”
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    Efficacy of doxycycline as add-on to interferon beta-1a in treatment of multiple sclerosis
  4. 1444
    “…We have generated transgenic mice that harbor humanized type I interferon receptors (IFNARs) enabling the study of type I human interferons (Hu-IFN-Is) in mice. …”
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    Bridging the Species Divide: Transgenic Mice Humanized for Type-I Interferon Response
  5. 1445
    por Ismail, Aimen, Yusuf, Nabiha
    Publicado 2014
    “…Interferons (IFNs) are a family of naturally existing glycoproteins known for their antiviral activity and their ability to influence the behavior of normal and transformed cell types. …”
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    Type I Interferons: Key Players in Normal Skin and Select Cutaneous Malignancies
  6. 1446
    “…BACKGROUND: Interferon-γ assays based on tuberculosis (TB)-specific antigens have been utilized for diagnosing and ruling out latent TB and active TB, but their utility is still limited for TB incidence countries. …”
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    Interferon-γ Enzyme-Linked Immunospot Assay in Patients with Tuberculosis and Healthy Adults
  7. 1447
    “…While it is known that type I interferon (IFN) limits lytic CMV replication, its role in latency and reactivation has not been explored. …”
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    Reversible Silencing of Cytomegalovirus Genomes by Type I Interferon Governs Virus Latency
  8. 1448
    “…The interferon (IFN)-inducible antiviral state is mediated in part by the 2′,5′-oligoadenylate (2-5A) synthetase (OAS)/RNase L system. 2-5A, produced from ATP by OAS proteins in response to viral double-stranded RNA, binds to and activates RNase L. …”
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    Cell-Type-Specific Effects of RNase L on Viral Induction of Beta Interferon
  9. 1449
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    Erratum: Regulation of Interferon Gamma Signaling by Suppressors of Cytokine Signaling and Regulatory T Cells
  10. 1450
    por Asmana Ningrum, Ratih
    Publicado 2014
    “…Human interferon alpha (hIFNα) is a wide biological activity cytokine that is used in hepatitis and cancer treatments. …”
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    Human Interferon Alpha-2b: A Therapeutic Protein for Cancer Treatment
  11. 1451
    “…A major problem in the formulation of therapeutic proteins is the irreversible protein aggregation. Recombinant human interferon alpha2b (rhIFNα2b) has poor stability and undergoes physical degradation. …”
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    Study on the Effect of Solution Conditions on Heat Induced-Aggregation of Human Alpha Interferon
  12. 1452
    “…INTRODUCTION: The purpose of this study was to evaluate the presence and levels of interferon-gamma inducible protein-10 (IP-10) in the plasma and skin of pediatric localized scleroderma (LS) patients compared to those of healthy pediatric controls and to determine if IP-10 levels correlate to clinical disease activity measures. …”
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    Interferon-gamma inducible protein-10 as a potential biomarker in localized scleroderma
  13. 1453
    “…Based on pathophysiological mechanisms and limited pre-clinical and clinical data, adjunctive immune-stimulatory therapy with interferon-gamma (IFN-γ) may represent a promising candidate to improve outcome of invasive fungal infections by enhancing host defence mechanisms. …”
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    Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series
  14. 1454
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    Interferon (IFNγ) induces cell cycle arrest in RCC cell lines
  15. 1455
    por AKAI, Makoto, HOBO, Seiji, WADA, Shinya
    Publicado 2009
    “…To assess the effect of human interferon-alpha (IFNα) on shipping fever of Thoroughbred racehorses subjected to long-distance transportation, an IFNα preparation was orally administered to 48 horses three times (once daily, 3 successive days) before transportation (IFNα group). …”
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    Effect of Low-Dose Human Interferon-alpha on Shipping Fever of Thoroughbred Racehorses
  16. 1456
    “…The purpose of this study was to develop a biobetter version of recombinant human interferon-β 1a (rhIFN-β 1a) to improve its biophysical properties, such as aggregation, production and stability, and pharmacokinetic properties without jeopardizing its activity. …”
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    Glycoengineering of Interferon-β 1a Improves Its Biophysical and Pharmacokinetic Properties
  17. 1457
    por Brod, Staley A.
    Publicado 2010
    “…We have proposed a unifying hypothesis of the etiopathogenesis of autoimmunity that defines autoimmunity as a type I interferon (IFN) immunodeficiency syndrome. We have examined toxicity and potential efficacy in two phase I (type 1 diabetes [T1D], multiple sclerosis [MS]) and phase II clinical trials in T1D and MS. …”
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    Ingested Type I Interferon—State of the Art as Treatment for Autoimmunity Part 2
  18. 1458
    “…PURPOSE: To evaluate the usefulness of the interferon-gamma release assay (IGRA) for diagnosing tuberculosis (TB)-related uveitis (TRU). …”
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    The Usefulness of Interferon-gamma Release Assay for Diagnosis of Tuberculosis-related Uveitis in Korea
  19. 1459
    “…She had been treated for hepatitis C with telaprevir, ribavirin, and interferon-alpha-2b for 6 months. Chest radiograph showed bilateral diffuse prominence of bronchovascular markings. …”
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    Interferon-alpha-induced sarcoidosis in a patient being treated for hepatitis C
  20. 1460
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    Haematological and molecular responses in patients with chronic ATLL treated with zidovudine and interferon-α
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