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1461por Kolokoltsova, Olga A., Grant, Ashley M., Huang, Cheng, Smith, Jennifer K., Poussard, Allison L., Tian, Bing, Brasier, Allan R., Peters, Clarence J., Tseng, Chien-Te Kent, de la Torre, Juan C., Paessler, Slobodan“…In addition, DNA fragmentation detected upon Candid#1 infection of type I interferon (IFN)-deficient Vero cells suggested a type I IFN-independent mechanism of apoptosis induction in response to JUNV. …”
Publicado 2014
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1462
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1463“…Interferons (IFNs) are important components in innate immunity involved in the first line of defense to protect host against viral infection. …”
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1464por Odendall, Charlotte, Dixit, Evelyn, Stavru, Fabrizia, Bierne, Helene, Franz, Kate M., Fiegen, Ann, Boulant, Steeve, Gehrke, Lee, Cossart, Pascale, Kagan, Jonathan C.“…Type I Interferon (IFN) responses are considered the primary means by which viral infections are controlled in mammals. …”
Publicado 2014
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1465por Egli, Adrian, Santer, Deanna M, O'Shea, Daire, Tyrrell, D Lorne, Houghton, Michael“…Type-III interferons (IFN-λ, IFNL) are the most recently described family of IFNs. …”
Publicado 2014
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1466por Weston, Stuart, Czieso, Stephanie, White, Ian J., Smith, Sarah E., Kellam, Paul, Marsh, Mark“…InterFeron Inducible TransMembrane proteins 1–3 (IFITM1, IFITM2 and IFITM3) are a family of proteins capable of inhibiting the cellular entry of numerous human and animal viruses. …”
Publicado 2014
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1467por Pfeffer, Lawrence M., Li, Kui, Fleckenstein, Jaquelyn F., Marion, Tony N., Diament, Joel, Yang, Chuan He, Pfeffer, Susan R., Fan, Meiyun, Handorf, Elizabeth, Handorf, Charles R.“…Infection with the hepatitis C virus (HCV) is a major cause of chronic liver diseases and hepatocellular carcinoma worldwide, and thus represents a significant public health problem. The type I interferon (IFN), IFNα, has been successful in treating HCV-infected patients, but current IFN-based treatment regimens for HCV have suboptimal efficacy, and relatively little is known about why IFN therapy eliminates the virus in some patients but not in others. …”
Publicado 2014
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1468por Esen, Nilufer, Rainey-Barger, Emily K, Huber, Amanda K, Blakely, Pennelope K, Irani, David N“…We found that mice genetically deficient in the transcription factor, interferon (IFN) regulatory factor-7 (IRF7), made significantly higher CXCL13 protein levels in the CNS compared with wild-type (WT) controls. …”
Publicado 2014
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1469“…The development of biopharmaceutical agents, including the interferons (IFN), offers new treatment options for a wide range of medical conditions. …”
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1470por Reeves, Westley H, Zhuang, Haoyang, Xu, Yuan, Han, Shuhong, Wang, Hai, Yang, LijunEnlace del recurso
Publicado 2014
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1471por Guan, Jean, Miah, S. M. Shahjahan, Wilson, Zachary S., Erick, Timothy K., Banh, Cindy, Brossay, Laurent“…Type I interferons (IFN) are unique cytokines transcribed from intronless genes. …”
Publicado 2014
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1472por Zhang, Shu-Min, Zhu, Li-Hua, Chen, Hou-Zao, Zhang, Ran, Zhang, Peng, Jiang, Ding-Sheng, Gao, Lu, Tian, Song, Wang, Lang, Zhang, Yan, Wang, Pi-Xiao, Zhang, Xiao-Fei, Zhang, Xiao-Dong, Liu, De-Pei, Li, Hongliang“…Interferon regulatory factor 9 (IRF9) has various biological functions and regulates cell survival; however, its role in vascular biology has not been explored. …”
Publicado 2014
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1473por Fitzgerald, Denise C, O’Brien, Kate, Young, Andrew, Fonseca-Kelly, Zoe, Rostami, Abdolmohamad, Gran, Bruno“…The transcription factor interferon regulatory factor 3 (IRF3) is activated by pathogen recognition receptors and induces interferon-β production. …”
Publicado 2014
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1474
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1475por Goovaerts, Odin, Jennes, Wim, Massinga-Loembé, Marguerite, Ceulemans, Ann, Worodria, William, Mayanja-Kizza, Harriet, Colebunders, Robert, Kestens, LucEnlace del recurso
Publicado 2014
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1476por Abolfazli, Roya, Elyasi, Azam, Javadi, Mohammad Reza, Gholami, Kheirollah, Torkamandi, Hassan, Amir-Shahkarami, Mohammad, Etemadifar, Masoud, Nasr, Zahra“…The knowledge of correct using interferon-beta (IFN-β) and attitude toward medical care were assessed using self-reported questionnaires consisted of 25 items with validity of multidisciplinary panel and pre-testing on 20 patients. …”
Publicado 2014
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1477por Hara, Kyoko, Shirasuna, Koumei, Usui, Fumitake, Karasawa, Tadayoshi, Mizushina, Yoshiko, Kimura, Hiroaki, Kawashima, Akira, Ohkuchi, Akihide, Matsuyama, Shuichi, Kimura, Koji, Takahashi, Masafumi“…BACKGROUND: Type I interferons (IFNs), including IFN-alpha (IFNA) and IFN-beta (IFNB), have anti-inflammatory properties and are used to treat patients with autoimmune and inflammatory disorders. …”
Publicado 2014
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1479por Zuo, Hui, Tell, Grethe S, Vollset, Stein E, Ueland, Per M, Nygård, Ottar, Midttun, Øivind, Meyer, Klaus, Ulvik, Arve, Eussen, Simone JPM“…BACKGROUND: It has been reported that interferon-γ (IFN-γ)–induced inflammatory markers, such as circulating neopterin and kynurenine-to-tryptophan ratio (KTR), are increased in patients with cancer and are also a predictor of poor prognosis. …”
Publicado 2014
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1480“…OBJECTIVE: The effect of interleukin (IL)-29, a new therapeutic agent similar to type I interferons (IFNs), on IFN-α secretion of human plasmacytoid dendritic cells (pDCs) has not been studied. …”
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