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1501por Chen, Jieliang, Wu, Min, Wang, Fan, Zhang, Wen, Wang, Wei, Zhang, Xiaonan, Zhang, Jiming, Liu, Yinghui, Liu, Yi, Feng, Yanling, Zheng, Ye, Hu, Yunwen, Yuan, Zhenghong“…Here, an elevation of the proportion of HBV spliced variants in the sera of patients with chronic hepatitis B (CHB) is shown to correlate with an impaired respond to interferon-α (IFN-α) therapy. Transfection of the constructs encoding the three most dominant species of spliced variants into cells or ectopic expression of the two major spliced protein including HBSP and N-terminal-truncated viral polymerase protein result in strong suppression of IFN-α signaling transduction, while mutation of the major splicing-related sites of HBV attenuates the viral anti-IFN activities in both cell and mouse models. …”
Publicado 2015
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1502
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1503Acute Changes in Striatal Microstructure Predict the Development of Interferon-Alpha Induced Fatiguepor Dowell, Nicholas G., Cooper, Ella A., Tibble, Jeremy, Voon, Valerie, Critchley, Hugo D., Cercignani, Mara, Harrison, Neil A.“…BACKGROUND: Interferon-alpha (IFN-α) is a key mediator of antiviral immune responses used clinically for hepatitis C treatment. …”
Publicado 2016
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1504
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1505por Hegen, Harald, Adrianto, Indra, Lessard, Christopher J., Millonig, Alban, Bertolotto, Antonio, Comabella, Manuel, Giovannoni, Gavin, Guger, Michael, Hoelzl, Martina, Khalil, Michael, Fazekas, Franz, Killestein, Joep, Lindberg, Raija L.P., Malucchi, Simona, Mehling, Matthias, Montalban, Xavier, Rudzki, Dagmar, Schautzer, Franz, Sellebjerg, Finn, Sorensen, Per Soelberg, Deisenhammer, Florian, Steinman, Lawrence, Axtell, Robert C.“…OBJECTIVE: To evaluate serum cytokine profiles for their utility to determine the heterogeneous responses to interferon (IFN)–β treatment in patients with multiple sclerosis (MS). …”
Publicado 2016
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1506por Planet, Paul J., Parker, Dane, Cohen, Taylor S., Smith, Hannah, Leon, Justinne D., Ryan, Chanelle, Hammer, Tobin J., Fierer, Noah, Chen, Emily I., Prince, Alice S.“…A major component of the immune response to influenza virus is the production of type I and III interferons. Here we show that the immune response to infection with influenza virus causes an increase and restructuring of the upper respiratory microbiota in wild-type (WT) mice but not in Il28r(−/−) mutant mice lacking the receptor for type III interferon. …”
Publicado 2016
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1507por Tan, Haiyan, Zeng, Chun, Xie, Junbo, Alghamdi, Norah J., Song, Ya, Zhang, Hongbing, Zhou, Aimin, Jin, Di“…Therefore, the development and discovery of new drugs have become an urgent clinical need. Interferons (IFNs), a family of pleiotropic cytokines, exert antitumor activities due to their anti-proliferative, immunomodulatory and proapoptotic functions. …”
Publicado 2015
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1508por Majoros, Andrea, Platanitis, Ekaterini, Szappanos, Daniel, Cheon, HyeonJoo, Vogl, Claus, Shukla, Priyank, Stark, George R, Sexl, Veronika, Schreiber, Robert, Schindler, Christian, Müller, Mathias, Decker, Thomas“…Signal transducer and activator of transcription 1 (STAT1) plays a pivotal role in the innate immune system by directing the transcriptional response to interferons (IFNs). STAT1 is activated by Janus kinase (JAK)‐mediated phosphorylation of Y701. …”
Publicado 2016
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1509por Nistal-Villan, Estanislao, Poutou, Joanna, Rodríguez-Garcia, Estefania, Buñuales, Maria, Carte-Abad, Beatriz, Prieto, Jesus, Gonzalez-Aseguinolaza, Gloria, Hernandez-Alcoceba, Ruben, Larrea, Esther“…Development of reporter systems for in vivo examination of IFN-β induction or signaling of type I interferon (IFN-I) pathways is of great interest in order to characterize biological responses to different inducers such as viral infections. …”
Publicado 2016
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1510por El-Ahwany, Eman, Nagy, Faten, Zoheiry, Mona, ELGhannam, Maged, Shemis, Mohamed, Aboul-Ezz, Mohamed, Zada, Suher“…INTRODUCTION: Treatment of HCV using a combination of pegylated interferon (PEG-IFN) and ribavirin fails in about 40% of the patients with HCV genotype 4 infections, and it is physically and economically demanding. …”
Publicado 2016
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1512por Blohmke, Christoph J., Darton, Thomas C., Jones, Claire, Suarez, Nicolas M., Waddington, Claire S., Angus, Brian, Zhou, Liqing, Hill, Jennifer, Clare, Simon, Kane, Leanne, Mukhopadhyay, Subhankar, Schreiber, Fernanda, Duque-Correa, Maria A., Wright, James C., Roumeliotis, Theodoros I., Yu, Lu, Choudhary, Jyoti S., Mejias, Asuncion, Ramilo, Octavio, Shanyinde, Milensu, Sztein, Marcelo B., Kingsley, Robert A., Lockhart, Stephen, Levine, Myron M., Lynn, David J., Dougan, Gordon, Pollard, Andrew J.“…In participants developing enteric fever after oral infection, marked transcriptional and cytokine responses during acute disease reflected dominant type I/II interferon signatures, which were significantly associated with bacteremia. …”
Publicado 2016
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1513por Yamaguchi, Rui, Yamamoto, Takatoshi, Sakamoto, Arisa, Ishimaru, Yasuji, Narahara, Shinji, Sugiuchi, Hiroyuki, Yamaguchi, Yasuo“…Interferon (IFN)-gamma is highly expressed in atherosclerotic lesions and may have an important role in atherogenesis. …”
Publicado 2016
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1514“…DENV-induced production of IFN-λ1 was dependent on signaling pathways involving toll-like receptor (TLR)-3, interferon regulation factor (IRF)-3, and nuclear factor-kappaB (NF-κB). …”
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1515por PAUDEL, Sarad, VILLANUEVA, Marvin A., MIKOTA, Susan K., NAKAJIMA, Chie, GAIRHE, Kamal P., SUBEDI, Suraj, RAYAMAJHI, Nabin, SASHIKA, Mariko, SHIMOZURU, Michito, MATSUBA, Takashi, SUZUKI, Yasuhiko, TSUBOTA, Toshio“…We developed an interferon-γ release assay (IGRA) specific for Asian elephants (Elephas maximus). …”
Publicado 2016
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1516“…Type I interferons (including IFNαβ) are innate cytokines that may contribute to pathogenesis during Mycobacterium tuberculosis (Mtb) infection. …”
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1517por Zettl, Uwe Klaus, Bauer-Steinhusen, Ulrike, Glaser, Thomas, Hechenbichler, Klaus, Hecker, Michael“…METHODS: In this report, we considered physicians’ and patients’ evaluation of satisfaction with interferon beta-1b treatment efficacy for assessing the congruence in ratings. …”
Publicado 2016
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1518por Jansson, Deidre, Scotter, Emma L., Rustenhoven, Justin, Coppieters, Natacha, Smyth, Leon C. D., Oldfield, Robyn L., Bergin, Peter S., Mee, Edward W., Graham, E. Scott, Faull, Richard L. M., Dragunow, Mike“…METHODS: We exposed primary adult human brain pericytes to chronic interferon-gamma (IFNγ) for 4 days and measured associated functional aspects of pericyte biology. …”
Publicado 2016
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1519“…Interferon-gamma (IFNγ), a pleiotropic cytokine, is expressed in diverse neurodegenerative and neuroinflammatory conditions. …”
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1520por Wu, Hai Wei, Wang, Xuan, Zhang, Ling, Zhao, Hai Guang, Wang, Yan An, Su, Li Xin, Fan, Xin Dong, Zheng, Jia Wei“…The aim of this study was to evaluate the safety and efficacy of interferon-alpha (IFN-α) therapy for treatment of refractory KHE. …”
Publicado 2016
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