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1561“…AIM: To assess the effects of hepatitis E virus (HEV) on the production of type I interferons (IFNs) and determine the underlying mechanisms. …”
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1562por Chen, Kang, Fu, Qiang, Liang, Siping, Liu, Yiting, Qu, Wenting, Wu, Yongjian, Wu, Xinger, Wei, Lei, Wang, Yi, Xiong, Yujuan, Wang, Weijia, Wu, Minhao“…As a converging point of cytosolic DNA sense signaling, stimulator of interferon genes (STING) was reported to participate in host–pathogen interaction. …”
Publicado 2018
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1563“…This review article provides a general perspective of the experimental and clinical work surrounding the role of type-I, type-II, and type-III interferons (IFNs) in the pathophysiology of brain and spinal cord injury. …”
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1564“…Interferons (IFNs) are a family of cytokines providing a robust first line of host innate defense against pathogenic infection, and have now been part of the standard treatment for viral infection. …”
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1565por Poelaert, Katrien C. K., Van Cleemput, Jolien, Laval, Kathlyn, Favoreel, Herman W., Soboll Hussey, Gisela, Maes, Roger K., Nauwynck, Hans J.Enlace del recurso
Publicado 2018
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1566por Nishimura, Tomoyasu, Ota, Masaki, Mori, Masaaki, Hasegawa, Naoki, Kawabe, Hiroshi, Kato, Seiya“…We estimated the latent tuberculosis infection (LTBI) rate for foreign-born students at Keio University, Tokyo, Japan, using an interferon-γ release assay. The LTBI rate for students from countries with estimated tuberculosis incidence >100 cases/100,000 persons was high (10.0%). …”
Publicado 2018
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1567“…In contrast, paradoxical psoriasis is caused by the absence of TNF and represents an ongoing type-I interferon-driven innate inflammation that fails to elicit T-cell autoimmunity and lacks memory T cell-mediated relapses.…”
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1568por Wu, Chen-Si, Zhao, Qian, Zhang, Jun, Wang, Jing-Wen, Qian, Yu, Fan, Yu-Chen, Wang, Kai“…The stimulator of interferon genes (STING) plays a crucial role in the recognition of a viral infection and subsequent stimulation of an immune response. …”
Publicado 2018
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1569por Doyle, Tomas, Moncorgé, Olivier, Bonaventure, Boris, Pollpeter, Darja, Lussignol, Marion, Tauziet, Marine, Apolonia, Luis, Catanese, Maria-Teresa, Goujon, Caroline, Malim, Michael H.“…Interferons (IFNs) mediate cellular defence against viral pathogens by upregulation of interferon-stimulated genes (ISGs) whose products interact with viral components or alter cellular physiology to suppress viral replication (1–3). …”
Publicado 2018
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1570por Sarhan, Joseph, Liu, Beiyun C., Muendlein, Hayley I., Weindel, Chi G., Smirnova, Irina, Tang, Amy Y., Ilyukha, Vladimir, Sorokin, Maxim, Buzdin, Anton, Fitzgerald, Katherine A., Poltorak, Alexander“…Interferons (IFNs) are critical determinants in immune-competence and autoimmunity, and are endogenously regulated by a low-level constitutive feedback loop. …”
Publicado 2018
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1571por Caine, Elizabeth A., Scheaffer, Suzanne M., Arora, Nitin, Zaitsev, Konstantin, Artyomov, Maxim N., Coyne, Carolyn B., Moley, Kelle H., Diamond, Michael S.“…Here we show that treatment of primary human vaginal and cervical epithelial cells with interferon (IFN)-α/β or IFN-λ induces host defense transcriptional signatures and inhibits ZIKV infection. …”
Publicado 2019
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1572por Scheu, Stefanie, Ali, Shafaqat, Mann-Nüttel, Ritu, Richter, Lisa, Arolt, Volker, Dannlowski, Udo, Kuhlmann, Tanja, Klotz, Luisa, Alferink, Judith“…It often affects young adults and can lead to neurological disability. Interferon β (IFNβ) preparations represent widely used treatment regimens for patients with relapsing-remitting MS (RRMS) with therapeutic efficacy in reducing disease progression and frequency of acute exacerbations. …”
Publicado 2019
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1573por Eggenberger, Julie, Blanco-Melo, Daniel, Panis, Maryline, Brennand, Kristen J., tenOever, Benjamin R.“…Upon virus infection, pluripotent stem cells neither induce nor respond to canonical type I interferons (IFN-I). To better understand this biology, we characterized induced pluripotent stem cells (iPSCs) as well as their differentiated parental or rederived counterparts. …”
Publicado 2019
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1574por Stein, Natan, Berhani, Orit, Schmiedel, Dominik, Duev-Cohen, Alexandra, Seidel, Einat, Kol, Inbal, Tsukerman, Pinchas, Hecht, Merav, Reches, Adi, Gamliel, Moriya, Obeidat, Akram, Charpak-Amikam, Yoav, Yamin, Rachel, Mandelboim, Ofer“…The lncRNA IFNG-AS1 was found to strongly influence the responses to several pathogens in mice by increasing interferon gamma (IFNγ) secretion. Studies have looked at IFNG-AS1 in T cells, yet IFNG-AS1 function in natural killer cells (NKs), an important source of IFNγ, remains unknown. …”
Publicado 2019
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1576por Kalra, Priyata, Brandl, Julian, Gaub, Thomas, Niederalt, Christoph, Lippert, Jörg, Sahle, Sven, Küpfer, Lars, Kummer, UrsulaEnlace del recurso
Publicado 2019
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1578
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1579“…We also show that the intestinal epithelium responds to EV71 infection through the selective induction of type III interferons (IFNs), which restrict EV71 replication. …”
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1580“…Similarly, IFN-I and interferon-stimulated gene (ISG) products can harness autophagy to regulate antiviral immunity. …”
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