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1581“…Background: Increased expression of type I interferon (IFN)-regulated genes has been described in blood and tissue cells from patients with systemic lupus erythematosus (SLE) and other rheumatic disorders. …”
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1582“…METHODS: The two-dimensional gel electrophoresis (2-DE) was applied in the context of the breast cancer model system to investigate the effect of interferon-gamma (IFN-γ) on the differential protein expression in breast cancer-derived cell lines CAMA-1 and 3,4-methylenedioxyamphetamine (MDA)-MB-231. …”
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1583por Iwasa, Masami, Harada, Takeshi, Oda, Asuka, Bat-Erdene, Ariunzaya, Teramachi, Jumpei, Tenshin, Hirofumi, Ashtar, Mohannad, Oura, Masahiro, Sogabe, Kimiko, Udaka, Kengo, Fujii, Shiro, Nakamura, Shingen, Miki, Hirokazu, Kagawa, Kumiko, Ozaki, Shuji, Abe, Masahiro“…Immunotherapy is revolutionizing the treatment paradigm for multiple myeloma (MM). Interferon (IFN)-γ is essential for immune responses, whereas immune checkpoint molecules, such as programmed cell death-1 ligand-1 (PD-L1), mitigate the beneficial anti-tumor immune responses. …”
Publicado 2019
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1584por de Jong, Tamarah D., Snoek, Tanja, Mantel, Elise, van der Laken, Conny J., van Vollenhoven, Ronald F., Lems, Willem F.“…Objective: The type I interferon (IFN) response in rheumatoid arthritis (RA) has been extensively studied in relation to therapy with biological DMARDs (bDMARDs). …”
Publicado 2019
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1585“…The mechanisms promoting the increase in interferon alpha expression and the role interferon alpha plays in IBC remain speculative. …”
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1586por Zhong, Sheng, Li, Weihang, Bai, Yang, Wu, Bo, Wang, Xinhui, Jiang, Shanshan, Zhao, Yingjing, Ren, Jiaxin, Li, Hui, Jin, RihuaEnlace del recurso
Publicado 2019
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1587
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1588por Forthun, Rakel Brendsdal, Hellesøy, Monica, Sulen, André, Kopperud, Reidun Kristin, Sjøholt, Gry, Bruserud, Øystein, McCormack, Emmet, Gjertsen, Bjørn Tore“…PURPOSE: Valproic acid (VPA) is suggested to be therapeutically beneficial in combination with interferon-alpha (IFNα) in various cancers. Therefore, we examined IFNα and VPA alone and in combinations in selected AML models, examining immune regulators and intracellular signaling mechanisms involved in phospho-proteomics. …”
Publicado 2019
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1589por von Gamm, Matthias, Schaub, Annalisa, Jones, Alisha N., Wolf, Christine, Behrens, Gesine, Lichti, Johannes, Essig, Katharina, Macht, Anna, Pircher, Joachim, Ehrlich, Andreas, Davari, Kathrin, Chauhan, Dhruv, Busch, Benjamin, Wurst, Wolfgang, Feederle, Regina, Feuchtinger, Annette, Tschöp, Matthias H., Friedel, Caroline C., Hauck, Stefanie M., Sattler, Michael, Geerlof, Arie, Hornung, Veit, Heissmeyer, Vigo, Schulz, Christian, Heikenwalder, Mathias, Glasmacher, ElkeEnlace del recurso
Publicado 2019
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1590“…Consisting of nearly 60 functional genes, porcine interferon (IFN)-complex represents an evolutionary surge of IFN evolution in domestic ungulate species. …”
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1591“…Here, we show that HHV-8-encoded viral interferon regulatory factor 1 (vIRF-1) promotes mitochondrial clearance by activating mitophagy to support virus replication. …”
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1592por He, Xing, Liu, Li-Ying, Ji, Xiao-Kun, Xian, Ya-Bin, Yan, Yong-Jun, Xu, Hui-Juan, Sha, Li, Pu, Chun-Li, Zhou, Jun-Yan, Yuan, Chun-Yan, Yang, Mei, Zheng, Song-Guo“…We stimulated T-cell proliferation to secret interferon gamma (IFN-γ) by phytohemagglutinin, and then measured the production of IFN-γ (mitogen value [M value]). …”
Publicado 2019
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1593por Brockwell, Natasha K., Rautela, Jai, Owen, Katie L., Gearing, Linden J., Deb, Siddhartha, Harvey, Kate, Spurling, Alex, Zanker, Damien, Chan, Chia-Ling, Cumming, Helen E., Deng, Niantao, Zakhour, Jasmine M., Duivenvoorden, Hendrika M., Robinson, Tina, Harris, Marion, White, Michelle, Fox, Jane, Ooi, Corinne, Kumar, Beena, Thomson, Jacqui, Potasz, Nicole, Swarbrick, Alex, Hertzog, Paul J., Molloy, Tim J., Toole, Sandra O’, Ganju, Vinod, Parker, Belinda S.“…Furthermore, we identified the tumor inherent interferon regulatory factor IRF9 as a marker of active intratumoral type I and II interferon (IFN) signaling and reduced risk of distant relapse. …”
Publicado 2019
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1594por Hölzer, Martin, Schoen, Andreas, Wulle, Julia, Müller, Marcel A., Drosten, Christian, Marz, Manja, Weber, Friedemann“…Antiviral interferons (IFN-alpha/beta) are possibly responsible for the high tolerance of bats to zoonotic viruses. …”
Publicado 2019
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1595“…Since its discovery in 2003, the type III interferon-λ (IFN-λ) family has been found to contribute significantly to the host response to infection. …”
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1596por Jordan, Stephen, Coss, Lisa, Wilson, Landon, Barnes, Stephen, Geisler, William, Nelson, David“…Animal models suggest that protection against CT is mediated through the cytokine interferon-gamma (IFN-γ), produced by CD4+ T-cells, which clears CT through intracellular tryptophan depletion. …”
Publicado 2019
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1597por Powers, Rani K., Culp-Hill, Rachel, Ludwig, Michael P., Smith, Keith P., Waugh, Katherine A., Minter, Ross, Tuttle, Kathryn D., Lewis, Hannah C., Rachubinski, Angela L., Granrath, Ross E., Carmona-Iragui, María, Wilkerson, Rebecca B., Kahn, Darcy E., Joshi, Molishree, Lleó, Alberto, Blesa, Rafael, Fortea, Juan, D’Alessandro, Angelo, Costello, James C., Sullivan, Kelly D., Espinosa, Joaquin M.“…Immune cells of people with DS overexpress IDO1, the rate-limiting enzyme in the kynurenine pathway (KP) and a known interferon (IFN)-stimulated gene. Furthermore, the levels of IFN-inducible cytokines positively correlate with KP dysregulation. …”
Publicado 2019
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1598por Williams, John V, Zhang, Yu, Xu, Jiuyang, Miranda-Katz, Margot, Rich, Helen, Manni, Michelle, Tollefson, Sharon, Sarkar, Saumendra, Alcorn, John“…C2-202-infected mice exhibited increased production of type I and III interferons (IFN) and pro-inflammatory cytokines, and lung neutrophil infiltration. …”
Publicado 2019
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1599“…The cytokine family type I interferon (IFN) is a major innate immune mediator extensively studied in the peripheral immune responses but largely under-investigated in AD. …”
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1600“…Nyala (Tragelaphus angasii), a large antelope species from Southern Africa, is frequently traded and can be infected with M. bovis. Interferon gamma (IFN-γ) release assays that detect cell-mediated immune (CMI) responses to M. bovis infection have shown promise in elephants, rhinoceroses and buffaloes. …”
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