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  1. 1601
    “…Type I interferons (IFNs), including alpha IFN (IFN-α) and IFN-β, potently suppress HIV-1 replication by upregulating IFN-stimulated genes (ISGs). …”
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    Multiple Pathways To Avoid Beta Interferon Sensitivity of HIV-1 by Mutations in Capsid
  2. 1602
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    Inhibition of type I interferon signaling abrogates early Mycobacterium bovis infection
  3. 1603
    “…The principal aim of this study was to evaluate the effects of interferon-γ (IFNγ) on the immunomodulatory effects of first-trimester human fetal cardiac (hfc)-MSCs. …”
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    Immunomodulatory effects of interferon-γ on human fetal cardiac mesenchymal stromal cells
  4. 1604
    “…BACKGROUND: The dysfunction of type I interferon (IFN) signaling is an important mechanism of immune escape and metastasis in tumors. …”
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    NOS1 inhibits the interferon response of cancer cells by S-nitrosylation of HDAC2
  5. 1605
    “…METHODS: Human NSCs were transfected with viral RNA mimics or infected with neurotropic virus for detecting the expression of antiviral interferons (IFNs) and downstream IFN-stimulated antiviral genes. …”
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    Activation of type I interferon antiviral response in human neural stem cells
  6. 1606
    “…The first report on the antitumor effects of interferon α/β (IFN-I) in mice was published 50 years ago. …”
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    Type I Interferons and Cancer: An Evolving Story Demanding Novel Clinical Applications
  7. 1607
    “…A case report of limbal conjunctival papilloma treatment with topical interferon alpha-2b eye drops applied to the conjunctival sac. …”
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    Treatment of conjunctival papilloma with topical interferon alpha-2b - case report
  8. 1608
    “…BACKGROUND: Interferon-γ (IFN-γ, a type II IFN) is present in the central nervous system (CNS) under various conditions. …”
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    Interferon-γ acutely augments inhibition of neocortical layer 5 pyramidal neurons
  9. 1609
    “…Inflammatory stress was induced by lipopolysaccharide/interferon-γ (LPS/IFN-γ) treatment for 24 h in the absence or presence of 1 or 5 mM glycine. …”
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    Effect of Glycine on BV-2 Microglial Cells Treated with Interferon-γ and Lipopolysaccharide
  10. 1610
    “…This effect occurs with distinct, unrelated human viral pathogens and is recapitulated when macrophages are stimulated with the anti-viral cytokines interferon alpha or beta (IFNα or IFNβ). Importantly, the effect is abrogated when type-I interferon signalling is blocked, thus underscoring the importance of type-I interferons in this phenomenon. …”
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    Viral infection triggers interferon-induced expulsion of live Cryptococcus neoformans by macrophages
  11. 1611
    “…Interferon regulatory factor 3 (IRF3) and IRF7 are closely related IRF members and the major factors for the induction of interferons, a key component in vertebrate innate immunity. …”
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    Adaptations of Interferon Regulatory Factor 3 with Transition from Terrestrial to Aquatic Life
  12. 1612
    “…Specifically, NR1 T cells have been shown to be protective in mice, and this protection depends on the host’s ability to sense the cytokine gamma interferon (IFN-γ). However, it is unclear what role NR1 production or sensing of IFN-γ plays in T cell homing to the genital tract or T cell-mediated protection against C. trachomatis. …”
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    Gamma Interferon Is Required for Chlamydia Clearance but Is Dispensable for T Cell Homing to the Genital Tract
  13. 1613
    “…Infection of BALB/c mice with mouse hepatitis virus, strain JHM (MHV-JHM), at any of several intervals relative to ovalbumin (OVA) administration resulted in elevated OVA-specific IgG 2 a titers. Since gamma interferon (IFN) has been implicated as an up-regulator of IgG 2 a production, attempts were made to determine whether levels of this cytokine were modified in sera of infected mice. …”
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    The role of gamma interferon in infection of susceptible mice with murine coronavirus, MHV-JHM
  14. 1614
    por Zhong, Bo, Wang, Yan-Yi, Shu, Hong-Bing
    Publicado 2010
    “…Host pattern recognition receptors (PRRs) recognize invading viral pathogens and initiate a series of signaling cascades that lead to the expression of type I interferons (IFNs) and inflammatory cytokines. During the past decade, significant progresses have been made to characterize PRRs such as Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs) and elucidate the molecular mechanisms of TLR- and RLR-mediated signaling. …”
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    Regulation of virus-triggered type I interferon signaling by cellular and viral proteins
  15. 1615
    por Bamford, Connor G. G.
    Publicado 2020
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    mSphere of Influence: Interferon Ultra Is a Means To Fight Viral Disease
  16. 1616
    por García-Sastre, Adolfo
    Publicado 2011
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    2 methylate or not 2 methylate: viral evasion of the type I interferon response
  17. 1617
    por Totura, Allison L, Baric, Ralph S
    Publicado 2012
    “…The association SARS-CoV with aberrant cytokine, chemokine, and Interferon Stimulated Gene (ISG) responses in patients provided evidence that SARS-CoV pathogenesis is at least partially controlled by innate immune signaling. …”
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    SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon
  18. 1618
    por Seo, Young-Jin, Hahm, Bumsuk
    Publicado 2010
    “…Type I interferon (IFN), as its name implies, ‘interferes’ with virus replication by activating numerous genes. …”
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    Type I Interferon Modulates the Battle of Host Immune System Against Viruses
  19. 1619
    “…We report herein that interferon alfacon1, has potent in vitro antiviral activity against SARS-CoV. …”
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    Interferon alfacon1 is an inhibitor of SARS-corona virus in cell-based models
  20. 1620
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    Glycosylation Heterogeneity of Hyperglycosylated Recombinant Human Interferon-β (rhIFN-β)
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