“…PURPOSE: To describe the association of change in the baseline hemoglobin levels with the development of interferon (INF) retinopathy after the start of pegylated INF (PEG INF) and ribavirin for hepatitis C virus treatment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This interaction initiates signaling through mitochondrial antiviral signaling (MAVS) and interferon regulatory factor (IRF) proteins, resulting in the induction of type I interferons (IFN). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Interferons (IFNs) orchestrate antiviral responses in jawed vertebrates and can be classified into three types based on different aspects of their genomic organization, structure and receptors through which they signal and function. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Background: Injectable interferon-based therapies have been used to treat hepatitis C virus (HCV) infection since 1991. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Recently, research into the use of type I interferons in the treatment of cancer has intensified. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…An unbalanced immune response, characterized by a weak production of type I interferons (IFN-Is) and an exacerbated release of proinflammatory cytokines, contributes to the severe forms of the disease. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here we show that SARS-CoV-2 induces overt but delayed type-I interferon (IFN) responses. By screening 23 viral proteins, we find that SARS-CoV-2 NSP1, NSP3, NSP12, NSP13, NSP14, ORF3, ORF6 and M protein inhibit Sendai virus-induced IFN-β promoter activation, whereas NSP2 and S protein exert opposite effects. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In placental malaria, Plasmodium falciparum-infected red blood cells cause an inflammatory response that can interfere with maternal–fetal exchange, leading to poor growth. The type I interferon (IFN-I) pathway plays an immunomodulatory role in viral and bacterial infections, usually by suppressing inflammatory responses. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: A comprehensive understanding of host factors modulated by the antiviral cytokine interferon-α (IFNα) is imperative for harnessing its beneficial effects while avoiding its detrimental side-effects during HIV infection. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In contrast, xenomitochondrial mice displayed lower baseline interferon gene expression and an impairment in the interferon-dependent innate immune response upon immune challenge with herpes simplex virus, which resulted in decreased viral control. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we tested the inhibitory activities of the antiviral interferons of type I (IFN-α) and type III (IFN-λ) against SARS–CoV-2 and compared them with those against SARS–CoV-1, which emerged in 2003. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The induction of an interferon-mediated response is the first line of defense against pathogens such as viruses. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Inflammatory cytokines including interferons (IFN) form a primary line of defence against viral infections, and their chronic elevation is a hallmark feature of many autoimmune diseases. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We identified a range of response patterns in Atlantic salmon gene duplicates, with upregulation of all duplicates for some genes, like interferon regulatory factor 1 (IRF1) and interferon induced protein 44-like (IFI44.L), but only induction of one or a few duplicates of other genes, such as TAPBP and ERAP2. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Antiviral responses of interferons (IFNs) are crucial in the host immune response, playing a relevant role in controlling viralw infections. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Advanced MRI imaging (diffusion tensor imaging, DTI; functional MRI, fMRI; and resting-state fMRI, rs-fMRI) and retinal imaging (optical coherence tomography, OCT) were tested longitudinally in a small group of Friedreich’s ataxia patients participating in an open-label clinical trial testing the safety and the efficacy of 6-month treatment with interferon gamma. While the DTI indices documented the slow progression of fractional anisotropy loss, fMRI and rs-fMRI were significantly modified during and after treatment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Interferons play a critical role in the innate immune response against a variety of pathogens, such as HIV-1. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…PURPOSE: To report the efficacy of topical interferon alpha 2b in the treatment of refractory diabetic macular edema. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we report on protection against multidrug-resistant Mycobacterium tuberculosis (MDR-TB) infection using a combination of the human monoclonal IgA 2E9 antibody against the alpha-crystallin (Acr, HspX) antigen and mouse interferon-gamma in mice transgenic for the human IgA receptor, CD89. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso