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  1. 1681
    “…In this review, we summarized the potential mechanisms of FRs-associated immune and inflammatory signaling and their possible contribution to the development and progression of NAFLD, with an emphasis on FRs-mediated interferon signaling. Knowledge gaps are identified, and emerging pharmacotherapeutic molecules targeting the immune and inflammatory signaling for NAFLD are also discussed.…”
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    Flame Retardants-Mediated Interferon Signaling in the Pathogenesis of Nonalcoholic Fatty Liver Disease
  2. 1682
    por Kim, You-Me, Shin, Eui-Cheol
    Publicado 2021
    “…Coronavirus disease 2019 (COVID-19), the current pandemic disease, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Type I and III interferons (IFNs) are innate cytokines that are important in the first-line defense against viruses. …”
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    Type I and III interferon responses in SARS-CoV-2 infection
  3. 1683
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    Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response
  4. 1684
    “…As MG1 is highly sensitive to type I interferons (IFN-I), we then investigated whether we could identify IFN-I signaling differences between HIV-infected and uninfected MDM and found evidence of impaired IFN-α responsiveness within HIV-infected cells. …”
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    HIV-Infected Macrophages Are Infected and Killed by the Interferon-Sensitive Rhabdovirus MG1
  5. 1685
    “…Members of the interferon regulatory factor (IRF) gene family are crucial regulators of type I interferon signaling, which may play a role in the resistance of glioma to immune checkpoint blockade. …”
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    Interferon regulatory factor transcript levels correlate with clinical outcomes in human glioma
  6. 1686
    Publicado 2021
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    Retraction: Interferon characterization associates with asthma and is a potential biomarker of predictive diagnosis
  7. 1687
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    Neutralizing Autoantibodies to Type I Interferons in COVID-19 Convalescent Donor Plasma
  8. 1688
    “…Interferon-γ autoantibodies increase the risk of disseminated nontuberculous mycobacterial infections. …”
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    Bortezomib treatment for refractory nontuberculous mycobacterial infection in the setting of interferon gamma autoantibodies
  9. 1689
    “…Approved treatments for chronic infection include injectable type-I interferons and nucleos(t)ide reverse transcriptase inhibitors. …”
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    Review of Lambda Interferons in Hepatitis B Virus Infection: Outcomes and Therapeutic Strategies
  10. 1690
    “…INTRODUCTION: Recombinant bovine interferon alpha (rBoIFN-α) has been demonstrated to have antiviral activity. …”
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    Acute and Sub-chronic Toxicity Study of Recombinant Bovine Interferon Alpha in Rodents
  11. 1691
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    Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways
  12. 1692
    “…We observed the accumulation of distinct populations of both macrophages and T-lymphocytes expressing strong interferon-driven inflammatory gene signature at 3dpi. …”
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    Myeloid cell interferon responses correlate with clearance of SARS-CoV-2
  13. 1693
    por Zhao, Chenchen, Zhang, Yi, Zheng, Hong
    Publicado 2021
    “…However, many factors may influence alloreactive T cell responses in the host undergoing allo-HSCT, including the interaction of alloreactive T cells with both donor and recipient hematopoietic cells and host non-hematopoietic tissues, cytokines, chemokines and inflammatory mediators. Interferons (IFNs), including type I IFNs and IFN-γ, primarily produced by monocytes, dendritic cells and T cells, play essential roles in regulating alloreactive T cell differentiation and function. …”
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    The Effects of Interferons on Allogeneic T Cell Response in GVHD: The Multifaced Biology and Epigenetic Regulations
  14. 1694
    “…SIP was associated with 30% to 50% reductions in all circulating immune cell populations (lymphocytes, monocytes, and granulocytes), down-regulation of Type I interferon (IFN) antiviral gene expression, and a relative up-regulation of CD16(−) classical monocytes. …”
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    The Type I interferon antiviral gene program is impaired by lockdown and preserved by caregiving
  15. 1695
    “…Although the viral pathogenesis remains elusive, deficiency of effective antiviral interferon (IFN) responses upon SARS-CoV-2 infection has been recognized as a hallmark of COVID-19 contributing to the disease pathology and progress. …”
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    Immune evasion of SARS-CoV-2 from interferon antiviral system
  16. 1696
    “…A 48-year-old woman who had been receiving long-term interferon-β for 8 years for multiple sclerosis developed drug-induced World Health Organization group I pulmonary arterial hypertension. …”
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    Interferon-β–Induced Pulmonary Arterial Hypertension: Approach to Diagnosis and Clinical Monitoring
  17. 1697
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    Neutralizing Anti-interferon-γ Autoantibodies: an Ameliorating Factor in COVID-19 Infection?
  18. 1698
    “…The type II interferon (IFNγ) promotes resistance to intracellular pathogens. …”
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    Myeloid cell responsiveness to interferon-gamma is sufficient for initial resistance to Listeria monocytogenes
  19. 1699
    “…Previous studies reported that SARS-CoV-2 nonstructural protein 12 (NSP12) was able to suppress interferon-β (IFN-β) activation in IFN-β promoter luciferase reporter assays, which provided insights into the pathogenesis of COVID-19. …”
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    SARS-CoV-2 NSP12 Protein Is Not an Interferon-β Antagonist
  20. 1700
    por Zanoni, Ivan
    Publicado 2021
    “…Type I and type III interferons are among the most potent anti-viral cytokines produced by the immune system. …”
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    Interfering with SARS-CoV-2: are interferons friends or foes in COVID-19?
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