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1681“…In this review, we summarized the potential mechanisms of FRs-associated immune and inflammatory signaling and their possible contribution to the development and progression of NAFLD, with an emphasis on FRs-mediated interferon signaling. Knowledge gaps are identified, and emerging pharmacotherapeutic molecules targeting the immune and inflammatory signaling for NAFLD are also discussed.…”
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1682“…Coronavirus disease 2019 (COVID-19), the current pandemic disease, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Type I and III interferons (IFNs) are innate cytokines that are important in the first-line defense against viruses. …”
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1683por Chu, Lei, Li, Chenhui, Li, Yongxing, Yu, Qiuya, Yu, Huansha, Li, Chunhui, Meng, Wei, Zhu, Juanjuan, Wang, Quanyi, Wang, Chen, Cui, ShufangEnlace del recurso
Publicado 2021
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1684por Sandstrom, Teslin S., Ranganath, Nischal, Burke Schinkel, Stephanie C., Salahuddin, Syim, Meziane, Oussama, Côté, Sandra C., Costiniuk, Cecilia T., Jenabian, Mohammad-Ali, Angel, Jonathan B.“…As MG1 is highly sensitive to type I interferons (IFN-I), we then investigated whether we could identify IFN-I signaling differences between HIV-infected and uninfected MDM and found evidence of impaired IFN-α responsiveness within HIV-infected cells. …”
Publicado 2021
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1685por Lei, Jin, Zhou, Ming-Hui, Zhang, Fu-Chi, Wu, Kang, Liu, Sheng-Wen, Niu, Hong-Quan“…Members of the interferon regulatory factor (IRF) gene family are crucial regulators of type I interferon signaling, which may play a role in the resistance of glioma to immune checkpoint blockade. …”
Publicado 2021
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1686
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1687por Vazquez, Sara E., Bastard, Paul, Kelly, Kathleen, Gervais, Adrian, Norris, Philip J., Dumont, Larry J., Casanova, Jean-Laurent, Anderson, Mark S., DeRisi, Joseph L.Enlace del recurso
Publicado 2021
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1688por Rocco, Joseph M., Rosen, Lindsey B., Hong, Gloria H., Treat, Jennifer, Kreuzburg, Samantha, Holland, Steven M., Zerbe, Christa S.“…Interferon-γ autoantibodies increase the risk of disseminated nontuberculous mycobacterial infections. …”
Publicado 2021
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1689por Novotny, Laura A., Evans, John Grayson, Su, Lishan, Guo, Haitao, Meissner, Eric G.“…Approved treatments for chronic infection include injectable type-I interferons and nucleos(t)ide reverse transcriptase inhibitors. …”
Publicado 2021
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1690por Yu, Hai-Yang, Gao, Dong-Mei, Zhou, Wei, Xia, Bing-Bing, He, Zhi-Yuan, Wu, Bo, Jiang, Min-Zhi, Wang, Ming-Li, Zhao, Jun“…INTRODUCTION: Recombinant bovine interferon alpha (rBoIFN-α) has been demonstrated to have antiviral activity. …”
Publicado 2021
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1691
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1692por Singh, Dhiraj, Aladyeva, Ekaterina, Das, Shibali, Singh, Bindu, Esaulova, Ekaterina, Swain, Amanda, Ahmed, Mushtaq, Cole, Journey, Moodley, chivonne, Mehra, Smriti, Schlesinger, Larry, Artyomov, Maxim, Khader, Shabaana, Kaushal, Deepak“…We observed the accumulation of distinct populations of both macrophages and T-lymphocytes expressing strong interferon-driven inflammatory gene signature at 3dpi. …”
Publicado 2021
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1693“…However, many factors may influence alloreactive T cell responses in the host undergoing allo-HSCT, including the interaction of alloreactive T cells with both donor and recipient hematopoietic cells and host non-hematopoietic tissues, cytokines, chemokines and inflammatory mediators. Interferons (IFNs), including type I IFNs and IFN-γ, primarily produced by monocytes, dendritic cells and T cells, play essential roles in regulating alloreactive T cell differentiation and function. …”
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1694por Cole, Steven W., Cacioppo, John T., Cacioppo, Stephanie, Bone, Kyle, Del Rosso, Laura A., Spinner, Abigail, Arevalo, Jesusa M. G., Dizon, Thomas P., Capitanio, John P.“…SIP was associated with 30% to 50% reductions in all circulating immune cell populations (lymphocytes, monocytes, and granulocytes), down-regulation of Type I interferon (IFN) antiviral gene expression, and a relative up-regulation of CD16(−) classical monocytes. …”
Publicado 2021
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1695por Min, Yuan-Qin, Huang, Mengzhuo, Sun, Xiulian, Deng, Fei, Wang, Hualin, Ning, Yun-Jia“…Although the viral pathogenesis remains elusive, deficiency of effective antiviral interferon (IFN) responses upon SARS-CoV-2 infection has been recognized as a hallmark of COVID-19 contributing to the disease pathology and progress. …”
Publicado 2021
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1696por Raza, Farhan, Kozitza, Callyn, Chybowski, Amy, Goss, Kara N., Berei, Theodore, Runo, James, Eldridge, Marlowe, Chesler, Naomi“…A 48-year-old woman who had been receiving long-term interferon-β for 8 years for multiple sclerosis developed drug-induced World Health Organization group I pulmonary arterial hypertension. …”
Publicado 2021
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1697por Kacar, Mark, Cortes-Acevedo, Paulina, Patel, Vinesh, Carter, Clive, Hughes, Pamela, McGann, Hugh P., Gkrania-Klotsas, Effrossyni, Baxendale, Helen E., Barcenas-Morales, Gabriela, Doffinger, Rainer, Savic, SinisaEnlace del recurso
Publicado 2021
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1698por Eshleman, Emily M., Bortell, Nikki, McDermott, Daniel S., Crisler, William J., Lenz, Laurel L.“…The type II interferon (IFNγ) promotes resistance to intracellular pathogens. …”
Publicado 2020
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1699por Li, Aixin, Zhao, Kaitao, Zhang, Bei, Hua, Rong, Fang, Yujie, Jiang, Wuhui, Zhang, Jing, Hui, Lixia, Zheng, Yingcheng, Li, Yan, Zhu, Chengliang, Wang, Pei-Hui, Peng, Ke, Xia, Yuchen“…Previous studies reported that SARS-CoV-2 nonstructural protein 12 (NSP12) was able to suppress interferon-β (IFN-β) activation in IFN-β promoter luciferase reporter assays, which provided insights into the pathogenesis of COVID-19. …”
Publicado 2021
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1700por Zanoni, Ivan“…Type I and type III interferons are among the most potent anti-viral cytokines produced by the immune system. …”
Publicado 2021
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