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1701por Legrain, Sarah, Su, Dan, Gaignage, Mélanie, Breukel, Cor, Claassens, Jill, Brouwers, Conny, Linssen, Margot M., Izui, Shozo, Verbeek, J. Sjef, Coutelier, Jean-Paul“…Infection with viruses, such as the lactate dehydrogenase-elevating virus (LDV), is known to trigger the onset of autoimmune anemia through the enhancement of the phagocytosis of autoantibody-opsonized erythrocytes by activated macrophages. Type I interferon receptor-deficient mice show enhanced anemia, which suggests a protective effect of these cytokines, partly through the control of type II interferon production. …”
Publicado 2021
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1702por Harrison, Angela R., David, Cassandra T., Rawlinson, Stephen M., Moseley, Gregory W.“…Viral interferon (IFN) antagonist proteins mediate evasion of IFN-mediated innate immunity and are often multifunctional, with distinct roles in viral replication. …”
Publicado 2021
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1703por Aref, Salah, Zaki, Aymen, El Mahdi, Essam Mostafa, Adel, Eman, Bahgat, Monier, Gouda, Enas“…BACKGROUND: Recent reports suggested relation between Interferon Gamma (IFN-γ) gene polymorphism and the risk of development of HCC on top of hepatic cirrhosis. …”
Publicado 2021
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1704“…Conjunctival intraepithelial neoplasia (CIN) is a type of OSSN that be medically managed by either topical interferon alpha-2b (IFN α-2b), 5-fluorouracil (5-FU), or mitomycin C. …”
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1705“…As conventional diagnostic methods for TBM are unsatisfactory, interferon-γ release assays (IGRAs) have been introduced for TBM diagnosis tentatively. …”
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1706“…The cytosolic DNA sensor cyclic-GMP-AMP synthase (cGAS) and its downstream effector, stimulator of interferon genes (STING), mediate innate immune signaling by promoting the release of type I interferons (IFNs) and other inflammatory cytokines. …”
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1707por Gozman, Leonid, Perry, Kellie, Nikogosov, Dimitri, Klabukov, Ilya, Shevlyakov, Artem, Baranova, Ancha“…In particular, various members of Class III interferons (lambda) are reviewed in detail.…”
Publicado 2021
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1708por D’Souza, Shanti S., Zhang, Yuanyue, Bailey, Jacob T., Fung, Ivan T. H., Kuentzel, Marcy L., Chittur, Sridar V., Yang, Qi“…Blockade of type‐1 interferon signaling by treatment with anti‐IFNAR1 neutralizing antibodies rapidly ablated MO‐ifn cells. …”
Publicado 2021
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1709por Nettis, Maria Antonietta, Lawrence, Andrew J., Wood, Tobias, Mariani, Nicole, Nikkheslat, Naghmeh, Lombardo, Giulia, Enache, Daniela, Veronese, Mattia, Turkheimer, Federico E., Dazzan, Paola, Pariante, Carmine M., Mondelli, Valeria“…Quantitative relaxation times (T1 & T2) and Proton Density (PD) were measured in n = 6 healthy males (mean age = 30.5 ± 6.8 years) in two MRI assessments collected before and 24 hours after a subcutaneous injection of the proinflammatory cytokine and immune activator, interferon-alpha (IFN-α). Serum levels of immune markers and markers of blood-brain barrier integrity (S100B) were also measured before and after the injection. …”
Publicado 2021
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1710por Tang, Peng, Virtue, Sam, Goie, Jian Yi Gerald, Png, Chin Wen, Guo, Jing, Li, Ying, Jiao, Huipeng, Chua, Yen Leong, Campbell, Mark, Moreno-Navarrete, José Maria, Shabbir, Asim, Fernández-Real, José-Manuel, Gasser, Stephan, Kemeny, David Michael, Yang, Henry, Vidal-Puig, Antonio, Zhang, Yongliang“…Dysfunction of adipocytes and adipose tissue is a primary defect in obesity and obesity-associated metabolic diseases. Interferon regulatory factor 3 (IRF3) has been implicated in adipogenesis. …”
Publicado 2021
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1711por Fan, Lilv, Xu, Guiliang, Cao, Jingjing, Li, Min, Zhang, Huihui, Li, Fanlin, Qi, Xinyue, Zhang, Xiaoqing, Li, Zeyu, Han, Ping, Yang, Xuanming“…The purpose of our research was to investigate the mechanisms underlying the immune response during CRPC development and to screen effective immunotherapies against CRPC. We found that interferon-α (IFNα) directly inhibited the progression of CRPC, reduced the accumulation of the immune suppressive granulocytic myeloid-derived suppressor cells (G-MDSCs) in the tumor microenvironment (TME), and impaired the inhibitory function of G-MDSCs on T cell activation. …”
Publicado 2021
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1712por Raadsen, Matthijs P., Gharbharan, Arvind, Jordans, Carlijn C. E., Mykytyn, Anna Z., Lamers, Mart M., van den Doel, Petra B., Endeman, Henrik, van den Akker, Johannes P. C., GeurtsvanKessel, Corine H., Koopmans, Marion P. G., Rokx, Casper, Goeijenbier, Marco, van Gorp, Eric C. M., Rijnders, Bart J. A., Haagmans, Bart L.“…PURPOSE: To study the effect of interferon-α2 auto-antibodies (IFN-α2 Abs) on clinical and virological outcomes in critically ill COVID-19 patients and the risk of IFN-α2 Abs transfer during convalescent plasma treatment. …”
Publicado 2021
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1713“…Interferons (IFNs) are cytokines that possess antiviral, antiproliferative, and immunomodulatory actions. …”
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1714por Molina, Guido Nicolás, Amalfi, Sabrina, Otero, Ignacio, Taboga, Oscar, Molinari, María PaulaEnlace del recurso
Publicado 2021
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1715por Liu, Chien Cheng, Lu, I Cheng, Wang, Li Kai, Chen, Jen Yin, Li, Yu Yu, Yang, Chih Ping, Liu, Ping Hsin, Cheng, Wan Jung, Tan, Ping Heng“…Interferons (IFNs) are cytokines secreted by infected cells that can interfere with viral replication. …”
Publicado 2021
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1717por Huang, Sihao, Zhang, Wen, Katanski, Christopher D., Dersh, Devin, Dai, Qing, Lolans, Karen, Yewdell, Jonathan, Eren, A. Murat, Pan, Tao“…Biologically, we find interferon inducible Ψ modifications in interferon-stimulated gene transcripts which are consistent with a role of Ψ in enabling efficacy of mRNA vaccines. …”
Publicado 2021
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1718“…Finally, the putative signature genes were blasted through the common Cardiovascular Disease Knowledge Portal to explore if they were associated with cardiovascular disorder. Three interferon stimulated genes (IFIT2, IFIT3 and IFI44L), as well as key pathways, have been identified as potential biomarkers and therapeutic targets for ischemic cardiomyopathy, and their alternations or mutations have been proven to be strongly linked to cardiac disorders. …”
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1719por Makrinioti, Heidi, Bush, Andrew, Gern, James, Johnston, Sebastian Lennox, Papadopoulos, Nikolaos, Feleszko, Wojciech, Camargo, Carlos A., Hasegawa, Kohei, Jartti, Tuomas“…However, the nature of the relationship between interferon production and wheezing illnesses is controversial. …”
Publicado 2021
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1720por Belemezova, Kalina, Bochev, Ivan, Ivanova-Todorova, Ekaterina, Kyurkchiev, Stanimir, Kyurkchiev, Dobroslav“…An inflammatory environment precedes the immunosuppressive abilities of MSCs and this study was intended to better understand how umbilical cord MSCs (UCMSCs) react to the process of inflammation, regarding their basic characteristics and behavior when primed with the key pro-inflammatory cytokine, Interferon-γ (IFNγ). MATERIALS AND METHODS: Human MSCs from the umbilical cord were isolated, expanded, and treated with IFNγ. …”
Publicado 2021
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