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1721por Bastard, Paul, Zhang, Qian, Zhang, Shen-Ying, Jouanguy, Emmanuelle, Casanova, Jean-Laurent“…Type I interferons (IFNs) have broad and potent antiviral activity. …”
Publicado 2022
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1722por Zhao, Liyuan, Li, Liang, Xue, Mei, Liu, Xiang, Jiang, Chengfan, Wang, Wenzhe, Tang, Lijie, Feng, Li, Liu, Pinghuang“…Mechanistically, the antiviral activity of GSDMD was mediated through promoting the nonclassical release of antiviral beta interferon (IFN-β) and then enhancing the interferon-stimulated gene (ISG) responses. …”
Publicado 2022
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1723por Singh, Dhiraj K., Aladyeva, Ekaterina, Das, Shibali, Singh, Bindu, Esaulova, Ekaterina, Swain, Amanda, Ahmed, Mushtaq, Cole, Journey, Moodley, Chivonne, Mehra, Smriti, Schlesinger, Larry S., Artyomov, Maxim N., Khader, Shabaana A., Kaushal, Deepak“…These macrophages are significantly enriched in the lungs of macaques at 3dpi and harbor SARS-CoV-2 while expressing a strong interferon-driven innate anti-viral gene signature. …”
Publicado 2022
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1724“…The interactions of coronaviruses with host antiviral interferon pathways ultimately determine successful viral replication and SARS-CoV-2-induced pathogenesis. …”
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1725“…ABSTRACT IMPACT: This research will promote understanding the role of the Type-I Interferon signaling pathway during embryo implantation, potentially leading to a new diagnostic or treatment target in early pregnancy failure. …”
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1726
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1727“…In this study, we pretreated/primed mouse primary lung epithelial and endothelial cells with various inflammatory mediators and assessed cell type-dependent responses to different necroptosis inducers and their underlying mechanisms. We found that interferon-γ (IFNγ) as low as 1 ng/mL preferentially promoted necroptosis and accelerated the release of damage-associated molecular patterns from primary alveolar and airway epithelial cells but not lung microvascular endothelial cells. …”
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1728por Sohail, Aaqib, Iqbal, Azeem A., Sahini, Nishika, Chen, Fangfang, Tantawy, Mohamed, Waqas, Syed F.H., Winterhoff, Moritz, Ebensen, Thomas, Schultz, Kristin, Geffers, Robert, Schughart, Klaus, Preusse, Matthias, Shehata, Mahmoud, Bähre, Heike, Pils, Marina C., Guzman, Carlos A., Mostafa, Ahmed, Pleschka, Stephan, Falk, Christine, Michelucci, Alessandro, Pessler, Frank“…The compounds reversed infection-triggered interferon responses and modulated inflammation in human cells supporting non-productive and productive infection, in peripheral blood mononuclear cells, and in human lung tissue. …”
Publicado 2022
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1729por Li, Jia, Kemper, Thekla, Broering, Ruth, Chen, Jieliang, Yuan, Zhenghong, Wang, Xueyu, Lu, Mengji“…Hepatitis B virus (HBV) infection causes acute and chronic liver diseases, including severe hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). Interferon alpha 2a (IFNα-2a) is commonly used for treating chronic HBV infection. …”
Publicado 2022
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1730por Northcott, Melissa, Jones, Sarah, Koelmeyer, Rachel, Bonin, Julie, Vincent, Fabien, Kandane-Rathnayake, Rangi, Hoi, Alberta, Morand, Eric“…OBJECTIVES: Type 1 interferon (IFN) is key to the pathogenesis of SLE, evidenced by the expression of IFN-stimulated genes (ISGs) in most patients, but the clinical utility of serial ISG assessment remains unknown. …”
Publicado 2022
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1731por Schilling, Erik, Pfeiffer, Lukas, Hauschildt, Sunna, Koehl, Ulrike, Claus, Claudia“…Similar to RuV infection, exogenous interferon (IFN) β induced a loss of glycolytic reserve in M-MΦ, but in contrast to RuV no noticeable influence on CD14 expression was detected. …”
Publicado 2022
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1732por Zhao, Mengmeng, Li, Huawei, Zhang, Hang, Sha, Huiyang, Huang, Liangzong, Wang, Ruining“…Overexpression of TRIM4 increased the mRNA levels of interferon (IFN)-alpha, IFN-beta, RIG-I, MAVS, IRF3, IRF7, OAS1, IFIT3, and CCL5, TRIM4 up-regulated the activities of IFN-beta, NF-κB, and ISRE reporter. …”
Publicado 2022
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1733
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1734por Eto, Shohei, Nukui, Yoko, Tsumura, Miyuki, Nakagama, Yu, Kashimada, Kenichi, Mizoguchi, Yoko, Utsumi, Takanori, Taniguchi, Maki, Sakura, Fumiaki, Noma, Kosuke, Yoshida, Yusuke, Ohshimo, Shinichiro, Nagashima, Shintaro, Okamoto, Keisuke, Endo, Akifumi, Imai, Kohsuke, Kanegane, Hirokazu, Ohnishi, Hidenori, Hirata, Shintaro, Sugiyama, Eiji, Shime, Nobuaki, Ito, Masanori, Ohge, Hiroki, Kido, Yasutoshi, Bastard, Paul, Casanova, Jean-Laurent, Tanaka, Junko, Morio, Tomohiro, Okada, Satoshi“…PURPOSE: Autoantibodies (aAbs) to type I interferons (IFNs) have been found in <1% of individuals under the age of 60 in the general population, with the prevalence increasing among those over 65. …”
Publicado 2022
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1735por Detilleux, Dylane, Raynaud, Peggy, Pradet-Balade, Berengere, Helmlinger, Dominique“…Surprisingly, TELO2 and TRRAP depletion also induced the expression of type I interferon genes. Using a combination of nascent RNA, antibody-targeted chromatin profiling (CUT&RUN), ChIP, and kinetic analyses, we propose a model by which TRRAP directly represses the transcription of IRF9, which encodes a master regulator of interferon-stimulated genes. …”
Publicado 2022
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1736por Saleiro, Diana, Wen, Jeremy Q., Kosciuczuk, Ewa M., Eckerdt, Frank, Beauchamp, Elspeth M., Oku, Chidera V., Blyth, Gavin T., Fischietti, Mariafausta, Ilut, Liliana, Colamonici, Marco, Palivos, William, Atsaves, Paula A., Tan, Dean, Kocherginsky, Masha, Weinberg, Rona Singer, Fish, Eleanor N., Crispino, John D., Hoffman, Ronald, Platanias, Leonidas C.“…Interferons (IFNs) are key initiators and effectors of the immune response against malignant cells and also directly inhibit tumor growth. …”
Publicado 2022
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1737“…Ocular surface squamous neoplasia (OSSN) is the most common nonpigmented ocular surface neoplasm. Interferon-alpha (IFNα)-2b has been proved to be an effective immunotherapeutic agent to treat OSSN. …”
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1738por Chu, Zhaowei, Gu, Lei, Hu, Yeguang, Zhang, Xiaoyang, Li, Man, Chen, Jiajia, Teng, Da, Huang, Man, Shen, Che-Hung, Cai, Li, Yoshida, Toshimi, Qi, Yifeng, Niu, Zhixin, Feng, Austin, Geng, Songmei, Frederick, Dennie T., Specht, Emma, Piris, Adriano, Sullivan, Ryan J., Flaherty, Keith T., Boland, Genevieve M., Georgopoulos, Katia, Liu, David, Shi, Yang, Zheng, Bin“…We further identify Interferon Regulatory Factor 9 (IRF9) as a major direct target of STAG2 in melanoma cells via integrated RNA-seq, STAG2 ChIP-seq and H3K27ac HiChIP analyses. …”
Publicado 2022
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1739por Berillo, Dmitriy“…Materials and Methods: ReciGen and Rebif are pharmaceutical interferon beta-1a (IFNβ-1a) contained in preparations that are used for parenteral administration. …”
Publicado 2022
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1740por Senthilkumaran, Chandrika, Kroeker, Andrea L., Smith, Gregory, Embury-Hyatt, Carissa, Collignon, Brad, Ramirez-Medina, Elizabeth, Azzinaro, Paul A., Pickering, Bradley S., Diaz-San Segundo, Fayna, Weingartl, Hana M., de los Santos, Teresa“…In this study, we tested whether porcine interferon-α or λ3 (porIFNα or porIFNλ3) delivered by a replication-defective human type 5 adenovirus vector (Ad5-porIFNα or Ad5-porIFNλ3) could limit EBOV replication and shedding in domestic pigs. …”
Publicado 2022
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